{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:08:36Z","timestamp":1781737716222,"version":"3.54.5"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Iatrogenic nerve injury is a possible complication of axillary lymph node dissection (ALND), which remains standard-of-care for some breast cancer patients. Recently, several studies have demonstrated that nerves auto-fluoresce in near-ultraviolet light (NUVL). We describe three women with BC in whom a recently-developed NUVL camera was used to facilitate visualization of and prevent iatrogenic injury to the intercostobrachial, long thoracic, and thoracodorsal nerves during ALND.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>In all three women, ALND was deemed necessary per current guidelines for the treatment of locally-advanced breast cancer following neoadjuvant chemotherapy. The surgery was performed using standard-of-care surgical techniques, except that a Dendrite\u00ae Imaging System was employed to visualize the surgical field both in white light and NUVL. In all patients, all nerves fluoresced brightly throughout their course in the surgical field. Such visualization was crucial during resection of lymph nodes close to nerves. No peri-operative complications occurred and no evidence of neurological injury was evident at one-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>The Dendrite\u00ae Imaging System employs a NUVL light source and filter system to detect fluorescent signals emitted by neural tissue. These signals then pass through a filter system within the camera head, are captured by a chip, and are transmitted to a dedicated software platform for real-time analysis, processing, and relay to a display screen, allowing the surgical team to observe neural structures with clarity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In three breast cancer patients undergoing ALND, nerve autofluorescence under NUVL aided in visualizing and preventing injury to all nerves within the surgical field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110723","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T03:17:05Z","timestamp":1733714225000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Nerve autofluorescence to enhance nerve visualization during axillary lymph node dissection in three breast cancer patients: Case series"],"prefix":"10.1097","volume":"126","author":[{"given":"Nicola","family":"Rocco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Velotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio Bruno","family":"Nava","sequence":"additional","affiliation":[{"name":"Fondazione G.Re.T.A. (Group for Reconstructive and Therapeutic Advancements) ETS, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Catanuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"Ingenito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Musella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"11","key":"R1-81-20260508","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM198503143121102","article-title":"Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation","volume":"312","author":"Fisher","year":"1985","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"R2-81-20260508","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jama.2017.11470","article-title":"Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial","volume":"318","author":"Giuliano","year":"2017","journal-title":"Jama"},{"issue":"6","key":"R3-81-20260508","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1056\/NEJMoa012782","article-title":"A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer","volume":"349","author":"Veronesi","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"R4-81-20260508","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.annonc.2023.08.017","article-title":"Understanding breast cancer complexity to improve patient outcomes: the St Gallen International Consensus Conference for the Primary Therapy of Individuals with Early Breast Cancer 2023","volume":"34","author":"Curigliano","year":"2023","journal-title":"Ann. Oncol."},{"issue":"2","key":"R5-81-20260508","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.annonc.2023.11.016","article-title":"Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"35","author":"Loibl","year":"2024","journal-title":"Ann. Oncol."},{"issue":"11","key":"R6-81-20260508","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1586\/14737140.6.11.1629","article-title":"Sequelae following axillary lymph node dissection for breast cancer","volume":"6","author":"Sakorafas","year":"2006","journal-title":"Expert. Rev. Anticancer. Ther."},{"issue":"11","key":"R7-81-20260508","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1245\/s10434-023-13759-y","article-title":"Changes in surgical management of the axilla over 11 years - report on more than 1500 breast cancer patients treated with neoadjuvant chemotherapy on the prospective I-SPY2 trial","volume":"30","author":"Boughey","year":"2023","journal-title":"Ann. Surg. Oncol."},{"issue":"12","key":"R8-81-20260508","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1007\/s00464-020-08227-7","article-title":"Nerve spectroscopy: understanding peripheral nerve autofluorescence through photodynamics","volume":"35","author":"Dip","year":"2021","journal-title":"Surg. Endosc."},{"issue":"3","key":"R9-81-20260508","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s00464-021-08484-0","article-title":"Nerve autofluorescence in near-ultraviolet light markedly enhances nerve visualization in vivo","volume":"36","author":"Dip","year":"2022","journal-title":"Surg. Endosc."},{"issue":"3","key":"R10-81-20260508","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s00464-023-10627-4","article-title":"Fluorescence imaging to visualize the recurrent laryngeal nerve during thyroidectomy procedures: analysis of 65 cases and 81 nerves","volume":"38","author":"Dip","year":"2024","journal-title":"Surg. Endosc."},{"issue":"6","key":"R11-81-20260508","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1007\/s00464-021-08729-y","article-title":"Nerve autofluorescence under near-ultraviolet light: cutting-edge technology for intra-operative neural tissue visualization in 17 patients","volume":"36","author":"Dip","year":"2022","journal-title":"Surg. Endosc."},{"issue":"5","key":"R12-81-20260508","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg."},{"issue":"1","key":"R13-81-20260508","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejso.2012.10.010","article-title":"Persistent pain, sensory disturbances and functional impairment after immediate or delayed axillary lymph node dissection","volume":"39","author":"Andersen","year":"2013","journal-title":"Eur. J. Surg. Oncol."},{"issue":"18","key":"R14-81-20260508","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/jama.2009.1568","article-title":"Prevalence of and factors associated with persistent pain following breast cancer surgery","volume":"302","author":"G\u00e4rtner","year":"2009","journal-title":"Jama"},{"issue":"9","key":"R15-81-20260508","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jpain.2008.04.001","article-title":"Effect of axillary lymph node dissection on prevalence and intensity of chronic and phantom pain after breast cancer surgery","volume":"9","author":"Steegers","year":"2008","journal-title":"J. Pain"},{"issue":"4","key":"R16-81-20260508","doi-asserted-by":"crossref","first-page":"9315","DOI":"10.4238\/2014.January.24.13","article-title":"Anatomical information for intercostobrachial nerve preservation in axillary lymph node dissection for breast cancer","volume":"13","author":"Zhu","year":"2014","journal-title":"Genet. Mol. Res."},{"issue":"3","key":"R17-81-20260508","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(02)00074-1","article-title":"Phantom-limb pain: characteristics, causes, and treatment","volume":"1","author":"Flor","year":"2002","journal-title":"Lancet Neurol."},{"issue":"6","key":"R18-81-20260508","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s11307-012-0555-1","article-title":"Intraoperative fluorescence imaging of peripheral and central nerves through a myelin-selective contrast agent","volume":"14","author":"Cotero","year":"2012","journal-title":"Mol. Imaging Biol."},{"issue":"1","key":"R20-81-20260508","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/SLA.0000000000003130","article-title":"Fluorescence imaging of nerves during surgery","volume":"270","author":"Walsh","year":"2019","journal-title":"Ann. Surg."},{"issue":"12","key":"R21-81-20260508","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1002\/lary.26057","article-title":"Improved facial nerve identification during parotidectomy with fluorescently labeled peptide","volume":"126","author":"Hussain","year":"2016","journal-title":"Laryngoscope"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224015049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261224015049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:02:10Z","timestamp":1778277730000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2024.110723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2024.110723","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}