{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:12:22Z","timestamp":1778278342644,"version":"3.51.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is a frequent complication to multiple endocrine neoplasia type 1 (MEN1), presenting challenges due to increased risk of multi-gland disease and recurrence post parathyroidectomy (PTX). This case report examines the management of PHPT in a MEN1 patient, emphasizing possible benefits from intraoperative parathyroid autofluorescence imaging (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>\n                      A 21-year-old woman with MEN1 presented with mild hyperparathyroidism symptoms in 2014. Initial unilateral PTX in 2015 normalized plasma parathyroid hormone (PTH) and ionized calcium (Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ) but was followed by biochemical recurrence in 2018. In 2022 a subtotal PTX was performed using AF to reduce the risk of permanent hypoparathyroidism. This technique distinguished pathological from non-pathological parathyroid tissue. Most of two glands were removed, leaving a small rim of non-pathologic tissue, achieving long-term normalization of plasma PTH and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      . Despite prior pregnancy complications suspectedly related to hypercalcemia, she gave birth to a healthy child after the second PTX, who tested negative for MEN1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>This case highlights the complexity of managing MEN1-associated PHPT, demonstrating the importance of advanced surgical techniques like AF to minimize complications and enhance outcomes. Surgical and medical management of MEN1 is crucial given the high recurrence-rate. According to the literature, hypercalcemia in patients with PHPT may affect pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case-report emphasize the need for a tailored approach in MEN1-related PHPT, combining innovative surgical methods to optimize outcomes. Further research on the impact of MEN1 on pregnancy outcomes and the long-term efficacy of AF are essential for improving management strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110764","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T04:23:45Z","timestamp":1735014225000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Potential benefits of intraoperative parathyroid autofluorescence imaging in a patient with multiple endocrine neoplasia type 1 and hyperparathyroidism - A case report"],"prefix":"10.1097","volume":"126","author":[{"given":"Christine Holm","family":"Egeb\u00e6k","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Lilja-Fischer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rolighed","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"10","key":"R1-120-20260508","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ciresp.2018.06.014","article-title":"Primary hyperparathyroidism associated with MEN 1: experience in 71 cases","volume":"96","author":"Balsalobre Salmeron","year":"2018","journal-title":"Cir Esp (Engl Ed)"},{"issue":"1","key":"R2-120-20260508","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/cen.14112","article-title":"Single gland excision for MEN1-associated primary hyperparathyroidism","volume":"92","author":"Manoharan","year":"2020","journal-title":"Clin. 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