{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:35:33Z","timestamp":1792481733717,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This case report discusses the clinical manifestations, diagnosis and treatment of idiopathic scrotal calcinosis, and reviews the literature of similar cases, providing important reference for the diagnosis and treatment of this rare disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>Idiopathic scrotal calcinosis is a rare condition characterized by calcium deposition in the skin of the scrotum. We present a case of a 67-year-old male patient with idiopathic scrotal calcinosis, a rare condition characterized by calcium deposition in the skin of the scrotum. The patient initially noticed multiple nodular masses on his scrotum 30 years ago, which gradually increased in size and caused discomfort. Physical examination and enhanced CT scans revealed multiple, well-demarcated high-density nodules on the skin surface of the scrotum. The patient underwent surgical resection of the lesions, and histopathological findings confirmed the diagnosis of idiopathic skin calcium deposition in the scrotum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Idiopathic calcinosis scrotum (ISC) is a rare benign surgical skin disorder that primarily affects the skin of the scrotum.It is characterized by the spontaneous deposition of calcium in the dermis, resulting in the formation of multiple asymptomatic calcified nodules. ISC is usually diagnosed based on clinical presentation and confirmed by histological examination. ISC can be treated well with surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Idiopathic Scrotal Calcinosis is a rare but distinct dermatosurgical disorder that requires surgical excision for definitive diagnosis and treatment. In managing ISC, surgical excision remains the primary treatment option, offering good outcomes and patient satisfaction. It is important for clinicians to recognize ISC to avoid misdiagnosis and unnecessary medical interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2024.110770","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T04:23:57Z","timestamp":1735014237000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Idiopathic scrotal calcinosis: Case report and literature review"],"prefix":"10.1097","volume":"126","author":[{"given":"Xiaofeng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology, Zaozhuang Municipal Hospital, 41th, Zaozhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Urology, Zaozhuang Municipal Hospital, 41th, Zaozhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Outpatient, Zaozhuang Municipal Hospital, 41th, Zaozhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-125-20260508","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/01.dad.0000246465.25986.68","article-title":"Scrotal calcinosis results from calcification of cysts derived from hair follicles: a series of 20 cases evaluating the spectrum of changes resulting in scrotal calcinosis","volume":"29","author":"Shah","year":"2007","journal-title":"Am. J. Dermatopathol."},{"key":"R2-125-20260508","doi-asserted-by":"crossref","DOI":"10.5935\/2177-1235.2019RBCP0149","article-title":"Idiopathic scrotal calcinosis: an unusual skin disorder[J].Revista Brasileira de Cirurgia Pl\u00e1stica (RBCP)","author":"Pontes","year":"2019","journal-title":"Brazilian Journal of Plastic Sugery"},{"issue":"3","key":"R3-125-20260508","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.purol.2021.10.009","article-title":"Aspects cliniques anatomopatho- logiques et prise en charge de la calcinose scrotale [Clinical aspects and management of scrotal calcinosis]","volume":"32","author":"Rimtebaye","year":"2022","journal-title":"Prog. Urol."},{"issue":"5","key":"R4-125-20260508","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. 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