{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:54:41Z","timestamp":1787496881256,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020MH081"],"award-info":[{"award-number":["ZR2020MH081"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010669","name":"Department of Health of Shandong Province","doi-asserted-by":"publisher","award":["202001041369"],"award-info":[{"award-number":["202001041369"]}],"id":[{"id":"10.13039\/501100010669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Retiform hemangioendothelioma(RH) is a rare vascular tumor affecting patients over a wide age range without a gender predilection; only about 50 cases have been described so far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report a case of submandibular retiform hemangioendothelioma in a 58-year-old woman who had been diagnosed with RH 20 years ago and had experienced recurrence four times during the past 20 years. This will increase the limited number of such cases in the hope of gaining a better understanding of this rare type of tumor. The histological features of RH are characterized by arborizing blood vessels arranged in a testicular network pattern with endothelial cells arranged in a hobnail pattern. Immunohistochemistry revealed CD31, CD34, ERG, and other vascular markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Based on the morphological and immunohistochemical results, we diagnosed the patient with a rectiform hemangioendothelioma with local malignancy that transformed into angiosarcoma, with enlargement of the lymph nodes in the neck area, possibly indicating tumor lymph node metastasis. The patient underwent extended resection and completed 14 radiotherapy sessions. Follow-up at 3 months after surgery showed no recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RH is a low-grade malignant intermediate vascular tumor that is prone to recurrence and does not generally metastasize to distant sites. Patients with recurrent relapses may undergo malignant transformation or lymph node metastases. Treatment primarily relies on wide excision and adjuvant radiotherapy may be necessary when required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110869","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T01:21:01Z","timestamp":1736731261000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Retiform hemangioendothelioma: A case report and literature review"],"prefix":"10.1097","volume":"127","author":[{"given":"Lin","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dule","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-57-20260325","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00000478-199402000-00001","article-title":"A distinctive form of low-grade angiosarcoma delineated in a series of 15 cases","volume":"18","author":"Calonje,","year":"1994","journal-title":"Am. J. Surg. Pathol."},{"issue":"2 Pt 1","key":"R2-57-20260325","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0190-9622(00)90143-9","article-title":"Retiform hemangioendothelioma: another tumor associated with human herpesvirus type 8?","volume":"42","author":"Schommer,","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"R3-57-20260325","first-page":"528","article-title":"A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features","volume":"3","author":"Zhang,","year":"2010","journal-title":"Int J Clin Exp Pathol."},{"issue":"5","key":"R4-57-20260325","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-4362.2000.00841-1.x","article-title":"Retiform hemangioendothelioma","volume":"39","author":"El Darouti,","year":"2000","journal-title":"Int. J. Dermatol."},{"issue":"5","key":"R5-57-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int J Surg Lond Engl."},{"issue":"12","key":"R6-57-20260325","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1097\/PAS.0000000000001575","article-title":"Recurrent YAP1 and MAML2 gene rearrangements in retiform and composite Hemangioendothelioma","volume":"44","author":"Antonescu,","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"R7-57-20260325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/0378-6323.45223","article-title":"Retiform hemangioendothelioma with lymph node metastasis: a rare entity","volume":"75","author":"Bhutoria,","year":"2009","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"issue":"7","key":"R8-57-20260325","first-page":"480","volume":"44","author":"Lao","year":"2015"},{"issue":"1","key":"R9-57-20260325","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jaad.2009.12.014","article-title":"Retiform hemangioendothelioma treated with Mohs micrographic surgery","volume":"65","author":"Keiler,","year":"2011","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:16:45Z","timestamp":1774433805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":9,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.110869","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-11-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}