{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:12:11Z","timestamp":1774444331490,"version":"3.50.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Mesenchymal chondrosarcoma (MC) is a high-grade variant of chondrosarcoma, essentially composed of poorly differentiated spindle cells interspersed with areas of cartilage or chondroid matrix. MC is extremely rare; it only accounts for 0.1 % of head and neck tumors and for only 1 % of all chondrosarcomas (CSs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 21-year-old man presented with a medical history of a painful irritation at the dextral maxillary region, presented as a mass at the vestibule of the oral cavity near the upper molars, and had been misdiagnosed as a benign fibrous lesion and excised without performing a biopsy. Magnetic resonance imaging (MRI) revealed an invasive lesion filling the right maxillary sinus and penetrating the orbital floor. A biopsy was then performed and revealed an MC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>The patient underwent a wide surgical resection, except for the infraorbital region, in which the tumor was surrounded by a fibrous capsule separating it from the anatomical structures of the eye. Due to the lack of wide resection in the orbital floor area (to preserve the eyeball), we applied the chemotherapy that was done with cisplatin and doxorubicin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Confirmed diagnosis by biopsy and treatment, both surgical and chemical, with frequent follow-up are decisive factors in progressing MC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110874","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T01:20:58Z","timestamp":1736731258000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal chondrosarcoma of maxilla misdiagnosed as a benign fibrous lesion: A rare case report from Syria"],"prefix":"10.1097","volume":"127","author":[{"given":"Abdulrahman","family":"Abdo Shouman","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilla A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeel M.","family":"Kaadeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehia M.","family":"Haphian","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad M.","family":"Hamzeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Damascus, Damascus, Syrian Arab Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-62-20260325","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/1097-0142(195911\/12)12:6<1142::AID-CNCR2820120610>3.0.CO;2-D","article-title":"Unusual benign and malignant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas","volume":"12","author":"-LIGHTENSTEIN,","year":"1959","journal-title":"Cancer"},{"issue":"8","key":"R3-62-20260325","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.joms.2021.02.020","article-title":"Mesenchymal chondrosarcoma in the maxilla: a case report and literature review","volume":"79","author":"Stanbouly,","year":"2021","journal-title":"Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons"},{"issue":"Suppl. 1","key":"R4-62-20260325","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.4103\/0973-029X.141376","article-title":"Mesenchymal chondrosarcoma of mandible: a rare case report and review","volume":"18","author":"Singh,","year":"2014","journal-title":"Journal of oral and maxillofacial pathology : JOMFP"},{"issue":"1","key":"R5-62-20260325","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/jomfp.JOMFP_57_16","article-title":"Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla","volume":"21","author":"Kerketa,","year":"2017","journal-title":"Journal of oral and maxillofacial pathology : JOMFP"},{"issue":"4","key":"R6-62-20260325","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.4317\/medoral.16.e493","article-title":"Mesenchymal chondrosarcoma of maxilla: a rare case report","volume":"16","author":"Jaetli,","year":"2011","journal-title":"Medicina oral, patologia oral y cirugia bucal"},{"issue":"7","key":"R7-62-20260325","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1258\/0022215001906084","article-title":"Mesenchymal chondrosarcoma of the maxilla","volume":"114","author":"Chidambaram,","year":"2000","journal-title":"J. Laryngol. Otol."},{"issue":"2","key":"R9-62-20260325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0030-4220(91)90454-K","article-title":"Chondrosarcoma of the jaws: clinical findings, histopathology, and treatment","volume":"71","author":"Hackney,","year":"1991","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"issue":"1","key":"R10-62-20260325","first-page":"E39","article-title":"Chondrosarcoma of the temporomandibular joint. A case report and review of the literature","volume":"14","author":"Gallego,","year":"2009","journal-title":"Medicina oral, patologia oral y cirugia bucal"},{"issue":"5","key":"R11-62-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int J Surg Lond Engl."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:24:38Z","timestamp":1774434278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":9,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.110874","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-09-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}