{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:12:18Z","timestamp":1774444338106,"version":"3.50.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Necrotising soft tissue infection (NSTI) is an exceptionally dangerous infectious disease targeting soft tissues with high mortality as well as morbidity.<\/jats:p>\n                    <jats:p>The aim of reconstructive surgery after initial debridement is to maintain function as well as to achieve a satisfactory cosmetic result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>A 50-year-old male presented with necrotising soft tissue infection on the thorax and left upper arm following mastectomy for breast cancer. He underwent aggressive debridement and was left with a large complicated soft tissue defect on the thorax, abdomen and left axilla with a wound bed consisting of exposed bone, nerves and vessels. There were close to no adjacent skin edges to fixate the flap, due to the size of the defect. Reconstruction with a free musculocutaneous latissimus dorsi (LD) and split skin grafting was performed. Vacuum therapy was applied immediately over the free flap and the vascular pedicle, as well as the skin graft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Application of NPWT to the entire reconstructed area, including the free flap, in terms of achieving better and faster healing, is somewhat novel. Applying negative pressure wound therapy (NPWT) on free flaps is not a new practice but it has mostly been used as incisional therapy or when complications have occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our case shows a successful microsurgical reconstruction in a challenging area, with the direct application of NPWT perioperatively, without compromising flap survival, and with good patient outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110878","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T19:27:44Z","timestamp":1736796464000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Negative pressure wound therapy on a musculocutaneous free flap in no skin edge wound bed: A case report"],"prefix":"10.1097","volume":"127","author":[{"given":"Camilla","family":"Mensel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Juel","sequence":"additional","affiliation":[{"name":"Department of Plastic and Breast Surgery, Aalborg University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte Jul","family":"Kiil","sequence":"additional","affiliation":[{"name":"Department of Plastic and Breast Surgery, Aarhus University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Henrik Rohden","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Breast Surgery, Aarhus University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"3","key":"R1-66-20260325","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/S1473-3099(22)00583-7","article-title":"Necrotising soft-tissue infections","volume":"23","author":"Hua,","year":"2023","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"R2-66-20260325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2020.0577","article-title":"Necrotising fasciitis: a narrative review of the literature","volume":"82","author":"Damisa,","year":"2021","journal-title":"Br. J. Hosp. Med."},{"issue":"7","key":"R3-66-20260325","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.burns.2021.01.005","article-title":"Flap coverage for necrotising soft tissue infections: a systematic review","volume":"47","author":"Somasundaram,","year":"2021","journal-title":"Burns"},{"issue":"3","key":"R4-66-20260325","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jamaoto.2016.2981","article-title":"Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: a consensus review and recommendations from the enhanced recovery after surgery society","volume":"143","author":"Dort,","year":"2017","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"issue":"5","key":"R5-66-20260325","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1007\/s00266-021-02233-3","article-title":"Enhanced recovery pathways for flap-based reconstruction: systematic review and meta-analysis","volume":"45","author":"Tan,","year":"2021","journal-title":"Aesthetic Plast. Surg."},{"issue":"8","key":"R7-66-20260325","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bjoms.2022.04.003","article-title":"Effectiveness and safety of immediate application of negative pressure wound therapy in head and neck free flap reconstruction: a systematic review","volume":"60","author":"Marouf,","year":"2022","journal-title":"Br. J. Oral Maxillofac. Surg."},{"issue":"5","key":"R8-66-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"issue":"02","key":"R9-66-20260325","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1055\/s-0041-1736422","article-title":"Reconstruction of axillary defect due to necrotizing fasciitis and debridement using a free-flap transfer: a report of three cases","volume":"06","author":"Ogawa,","year":"2021","journal-title":"J Reconstr Microsurg Open."},{"issue":"11","key":"R10-66-20260325","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1002\/lary.27169","article-title":"Immediate negative pressure wound therapy after free flap transfer for head and neck cancer surgery","volume":"128","author":"Lin,","year":"2018","journal-title":"Laryngoscope"},{"issue":"1","key":"R11-66-20260325","doi-asserted-by":"crossref","first-page":"21158","DOI":"10.1038\/s41598-021-00369-5","article-title":"Immediate application of negative pressure wound therapy following lower extremity flap reconstruction in sixteen patients","volume":"11","author":"Chen,","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"R12-66-20260325","first-page":"197","article-title":"Negative pressure wound therapy in free muscle flaps-risk or benefit?","volume":"40","author":"Dornseifer,","year":"2023","journal-title":"J. Reconstr. Microsurg."},{"issue":"1","key":"R13-66-20260325","doi-asserted-by":"crossref","first-page":"143","DOI":"10.12998\/wjcc.v11.i1.143","article-title":"Devastating complication of negative pressure wound therapy after deep inferior epigastric perforator free flap surgery: a case report","volume":"11","author":"Lim,","year":"2023","journal-title":"World J. Clin. Cases"},{"issue":"1","key":"R14-66-20260325","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/iwj.12810","article-title":"Mechanical effects of negative pressure wound therapy on abdominal wounds - effects of different pressures and wound fillers","volume":"15","author":"Torbrand,","year":"2018","journal-title":"Int. Wound J."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:24:52Z","timestamp":1774434292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":13,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.110878","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-12-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}