{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:15:39Z","timestamp":1778616939268,"version":"3.51.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Mucosal melanoma of the oral cavity, a rare and aggressive malignant tumor, most commonly located in the hard palate or maxillary gingiva\/ridge, underscores the urgent need for early diagnosis. These tumors are typically asymptomatic, highlighting the crucial role of medical professionals in improving patient outcomes significantly through early detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We present a case of oral melanoma in a 62-year-old male patient with a history of diabetes mellitus and significant tobacco use. The patient presented with a painful mass on the left hard palate. Computed tomography (CT) imaging of the maxilla revealed a significant bone defect in the left maxillary canine-premolar region. An incisional biopsy of the mass confirmed the diagnosis of invasive melanoma. The patient subsequently underwent a left maxillectomy and was referred to an oncologist for further treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Oral melanoma, while uncommon, is a disease of grave concern due to its aggressive and invasive behavior. This demands immediate attention and action from medical professionals. Its asymptomatic nature frequently results in late-stage detection, significantly impacting treatment outcomes and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Clinicians should be vigilant about intraoral pigmented or atypical nonpigmented lesions. Lesions showing color changes or sudden enlargement should be biopsied and evaluated histopathologically. This vigilance is crucial for early diagnosis and treatment, which can significantly impact patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110902","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T04:58:42Z","timestamp":1738040322000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Malignant melanoma of the oral cavity: A case report"],"prefix":"10.1097","volume":"128","author":[{"given":"Negin","family":"Paruhan","sequence":"first","affiliation":[{"name":"Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fakhriyeh","family":"Kelavari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20260325","doi-asserted-by":"crossref","first-page":"S935","DOI":"10.4103\/jcrt.jcrt_1364_22","article-title":"Oral malignant melanoma - clinical presentation with immunohistochemical analysis","volume":"19","author":"Gunasekaran,","year":"2023","journal-title":"J. Can. Res. Ther."},{"issue":"8","key":"R2-4-20260325","first-page":"739","article-title":"Primary mucosal melanomas: a comprehensive review.Int","volume":"5","author":"Mihajlovic,","year":"2012","journal-title":"J. Clin. Exp. Pathol."},{"issue":"3","key":"R3-4-20260325","article-title":"A case report of oral malignant melanoma: a silent killer","volume":"15","author":"Kukde,","year":"2023","journal-title":"Cureus"},{"issue":"5","key":"R4-4-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."},{"issue":"4","key":"R5-4-20260325","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cden.2013.07.006","article-title":"Pigmented lesions of the oral cavity: an update","volume":"57","author":"Alawi,","year":"2013","journal-title":"Dent. Clin. N. Am."},{"issue":"1","key":"R6-4-20260325","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12105-014-0526-8","article-title":"Oral mucosal melanoma: some pathobiological considerations and an illustrative report of a case","volume":"9","author":"Tlholoe,","year":"2015","journal-title":"Head Neck Pathol."},{"issue":"3","key":"R7-4-20260325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3315\/jdcr.2014.1175","article-title":"Melanoma of the oral cavity: pathogenesis, dermoscopy, clinical features, staging and management","volume":"8","author":"Warszawik-Hendzel,","year":"2014","journal-title":"J. Dermatol. Case Rep."},{"key":"R8-4-20260325","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jaad.2014.03.031","article-title":"Update on primary mucosal melanoma","volume":"71","author":"Tacastacas,","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"R9-4-20260325","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/hed.20112","article-title":"Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck","volume":"26","author":"Prasad,","year":"2004","journal-title":"Head Neck"},{"key":"R10-4-20260325","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4103\/ijd.IJD_360_19","article-title":"A rare case of primary oral malignant melanoma of mandibular gingiva with an update on clinical staging","volume":"66","author":"Akhil,","year":"2021","journal-title":"Indian J. Dermatol."},{"issue":"2","key":"R11-4-20260325","doi-asserted-by":"crossref","DOI":"10.4081\/rt.2010.e25","article-title":"Malignant melanoma of the mandibular gingiva","volume":"2","author":"Fauzdar,","year":"2010","journal-title":"Rare Tumors"},{"issue":"2","key":"R12-4-20260325","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s40471-019-00192-7","article-title":"Sex differences in melanoma","volume":"6","author":"Schwartz,","year":"2019","journal-title":"Curr. Epidemiol. Rep."},{"issue":"3","key":"R13-4-20260325","first-page":"227","article-title":"Rare and extensive malignant melanoma of the oral cavity: report of two cases","volume":"18","author":"Deyhimi,","year":"2017","journal-title":"J. Dent. Shiraz Univ. Med. Sci."},{"issue":"3","key":"R14-4-20260325","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12105-016-0693-x","article-title":"Melanoma of the oral cavity: an analysis of 46 new cases with emphasis on clinical and histopathologic characteristics","volume":"10","author":"Smith,","year":"2016","journal-title":"Head Neck Pathol."},{"issue":"6","key":"R15-4-20260325","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1684\/ejd.2021.4171","article-title":"Clinical ABCDE rule for early melanoma detection","volume":"31","author":"Duarte,","year":"2021","journal-title":"Eur. J. Dermatol."},{"issue":"4","key":"R16-4-20260325","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4103\/0972-124X.92587","article-title":"Oral malignant melanoma: a silent killer?","volume":"15","author":"Padhye,","year":"2011","journal-title":"J. Indian Soc. Periodontol."},{"issue":"2","key":"R17-4-20260325","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4103\/0976-237X.132352","article-title":"Malignant melanoma of the oral cavity: report of two cases","volume":"5","author":"Munde,","year":"2014","journal-title":"Contemp. Clin. Dent."},{"issue":"9","key":"R18-4-20260325","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bjoms.2020.05.028","article-title":"Survival of oral mucosal melanoma according to treatment, tumour resection margin, and metastases","volume":"58","author":"Chae,","year":"2020","journal-title":"Br. J. Oral Maxillofac. Surg."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225000884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:25:07Z","timestamp":1774434307000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":18,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.110902","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}