{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:11:37Z","timestamp":1774444297074,"version":"3.50.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019155","name":"Nanjing Drum Tower Hospital","doi-asserted-by":"publisher","award":["2023100801"],"award-info":[{"award-number":["2023100801"]}],"id":[{"id":"10.13039\/501100019155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and importance:<\/jats:title>\n                    <jats:p>Currently, radical gastrectomy for gastric cancer is usually combined with lymph node tracing technology to ensure the complete removal of metastatic lymph nodes. Our case demonstrates that bismuth compounds may be useful as lymph node tracers in radical gastrectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 37-year-old man who was confirmed the diagnosis of gastric cancer was found to have black-stained lymph nodes during the surgical resection. The patient's medication history, pathological analysis and Inductively coupled plasma mass spectrometry (ICP-MS) confirmed the presence of dark particle deposited in the black-stained lymph nodes and the black particles were likely some form of bismuth compound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>At present, lymph node tracers used in clinical practice have certain unavoidable limitations. It is necessary to discover new lymph node tracers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>our case highlights a new potential avenue for the development of lymph node tracers in radical gastrectomy. However, it is essential to remain vigilant regarding the possible adverse consequences of overdose in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110930","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T03:53:54Z","timestamp":1737604434000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Unexpected black-stained lymph nodes: A case report"],"prefix":"10.1097","volume":"127","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Tao","sequence":"additional","affiliation":[{"name":"Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"1","key":"R1-109-20260325","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel,","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"R2-109-20260325","article-title":"Significance of lymph node metastasis in the treatment of gastric Cancer and current challenges in determining the extent of metastasis","volume":"11","author":"Kinami,","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"R3-109-20260325","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10120-018-0840-z","article-title":"Risk factors for lymph node metastasis in non-sentinel node basins in early gastric cancer: sentinel node concept","volume":"22","author":"Takeuchi,","year":"2019","journal-title":"Gastric Cancer"},{"issue":"1","key":"R4-109-20260325","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12916-021-02145-8","article-title":"Optimal site for fluoroscopic tracer injection for laparoscopic lymphadenectomy","volume":"19","author":"Herbella,","year":"2021","journal-title":"BMC Med."},{"issue":"5","key":"R5-109-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"issue":"23","key":"R6-109-20260325","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14235735","article-title":"Tracers in gastric Cancer surgery","volume":"14","author":"Li,","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"R7-109-20260325","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.1038\/s41467-023-42712-6","article-title":"Indocyanine green fluorescence imaging-guided versus conventional laparoscopic lymphadenectomy for gastric cancer: long-term outcomes of a phase 3 randomised clinical trial","volume":"14","author":"Chen,","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"R8-109-20260325","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/jamasurg.2019.6034","article-title":"Indocyanine green tracer-guided lymph node retrieval during radical dissection in gastric Cancer surgery","volume":"155","author":"Patti,","year":"2020","journal-title":"JAMA Surg."},{"issue":"5","key":"R9-109-20260325","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1007\/s00464-021-08630-8","article-title":"Safety and efficacy of carbon nanoparticle suspension injection and indocyanine green tracer-guided lymph node dissection during robotic distal gastrectomy in patients with gastric cancer","volume":"36","author":"Tian,","year":"2022","journal-title":"Surg. Endosc."},{"issue":"1","key":"R10-109-20260325","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/JS9.0000000000001873","article-title":"Effect of carbon nanoparticle suspension injection versus indocyanine green tracer in guiding lymph node dissection during radical gastrectomy (FUTURE-01): a randomized clinical trial","volume":"111","author":"Tian,","year":"2024","journal-title":"Int. J. Surg."},{"issue":"4","key":"R11-109-20260325","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10120-020-01044-w","article-title":"5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients","volume":"23","author":"Matsumoto,","year":"2020","journal-title":"Gastric Cancer"},{"issue":"56","key":"R12-109-20260325","doi-asserted-by":"crossref","first-page":"35392","DOI":"10.1039\/D1RA01947C","article-title":"Nanotechnology-based strategies for gastric cancer imaging and treatment","volume":"11","author":"Li,","year":"2021","journal-title":"RSC Adv."},{"issue":"21","key":"R13-109-20260325","doi-asserted-by":"crossref","first-page":"12037","DOI":"10.1039\/D0CS00031K","article-title":"Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles","volume":"50","author":"Griffith,","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"14","key":"R14-109-20260325","first-page":"1255","article-title":"\u67b8\u6a7c\u9178\u94cb\u94be\u81f4\u7ed3\u80a0\u9ad8\u5bc6\u5ea6\u663e\u5f711\u4f8b\u5206\u6790","volume":"30","author":"\u5218,","year":"2010","journal-title":"\u4e2d\u56fd\u533b\u9662\u836f\u5b66\u6742\u5fd7"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225001166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225001166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:24:09Z","timestamp":1774434249000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":14,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.110930","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-12-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}