{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:12:08Z","timestamp":1774444328531,"version":"3.50.1"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Primary urethral carcinoma (PUC) is a rare cancer, comprising less than 1 % of all genitourinary malignancies, with a male predominance (3:1 ratio), and typically affects those over 75 years of age. PUC shows varied histological subtypes based on their location and sex. The prognosis depends on age, tumor grade, TNM stage, histology, and site. Organ-preserving surgery is for distal disease becoming a preferred option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report the surgical management of a male patient presenting with a history of urethral meatal ulcer, bloody urethral discharge, dysuria, and urine spraying, initially misdiagnosed as a persistent herpes ulcer. Examination revealed a 1 \u00d7 2 cm erythematous plaque over the urethral meatus. Pelvic magnetic resonance imaging (MRI) showed a 1.7 \u00d7 1.7 cm lesion in the distal penile urethra invading the corpus spongiosum, and a biopsy confirmed squamous carcinoma in situ. The patient underwent partial glansectomy and anterior urethrectomy, but pathology showed well-differentiated squamous cell carcinoma with positive margins. The patient was successfully treated with a total anterior urethrectomy, partial glansectomy, and augmented perineal urethrostomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>PUC (primary urethral carcinoma) presents nonspecifically, requiring high suspicion for diagnosis. Historically, treatment included total penectomy with cystoprostatectomy for proximal tumors and partial or radical penectomy for distal tumors. Distal tumors often have better outcomes, and organ preservation surgery is possible for selected patients, with no local recurrence in those treated with additional surgery or adjuvant radiation for positive margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PUC is a rare urological malignancy that is challenging to diagnose and treat. Clinical stage and tumor location are critical prognostic factors for urethral carcinoma in men. Organ-preserving surgery is the preferred treatment for distal disease, with a 5-year overall survival rate of approximately 50 %.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110983","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T16:47:50Z","timestamp":1738169270000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Organ-preserving surgery for male distal primary urethral carcinoma: A case report from a tertiary hospital in Ethiopia"],"prefix":"10.1097","volume":"127","author":[{"given":"Alemu Bedeado","family":"Hirpo","sequence":"first","affiliation":[{"name":"Urology Division, Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sena Sefara","family":"Akasa","sequence":"additional","affiliation":[{"name":"Urology Division, Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mensur Mohammed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Urology Division, Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masresha Solomon","family":"Dino","sequence":"additional","affiliation":[{"name":"Urology Division, Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wondweson Alemu","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mintesnot Yitagesu","family":"Kidane","sequence":"additional","affiliation":[{"name":"Urology Division, Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"2","key":"R2-150-20260325","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/UA.UA_136_17","article-title":"Primary urethral carcinoma: a surveillance, epidemiology, and end results data analysis identifying predictors of cancer-specific survival","volume":"10","author":"Aleksic,","year":"2018","journal-title":"Urol. Ann."},{"key":"R3-150-20260325","first-page":"10","article-title":"Comparison between urothelial and non-urothelial urethral cancer","author":"Wenzel,","year":"2021","journal-title":"Front. Oncol."},{"key":"R4-150-20260325","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.2147\/CMAR.S184197","article-title":"Prognosis of rare pathological primary urethral carcinoma","volume":"10","author":"Abudurexiti,","year":"2018","journal-title":"Cancer Manag. Res."},{"issue":"28","key":"R5-150-20260325","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2011.36.5890","article-title":"Squamous cell carcinoma of the bulbar urethra","volume":"29","author":"Memon,","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"R6-150-20260325","first-page":"423","article-title":"A brief review on the diagnostic and therapeutic principles of primary urethral cancer","volume":"9","author":"Su,","year":"2022","journal-title":"Asian Journal of Urology. Editorial Office of Asian Journal of Urology"},{"key":"R7-150-20260325","first-page":"325","article-title":"Current perspectives on the diagnosis and management of primary urethral cancer: a systematic review","volume":"13","author":"Ryan Farrell,","year":"2021","journal-title":"Res. Rep. Urol."},{"issue":"3","key":"R8-150-20260325","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/bju.15095","article-title":"Primary urethral cancer: treatment patterns and associated outcomes","volume":"126","author":"Mano,","year":"2020","journal-title":"BJU Int."},{"issue":"1","key":"R9-150-20260325","doi-asserted-by":"crossref","first-page":"20","DOI":"10.14740\/wjon1360","article-title":"Diagnostic and therapeutic challenges of rare urogenital cancers: urothelial carcinoma of the renal pelvis, ureters and urethra","volume":"12","author":"Cassell,","year":"2021","journal-title":"World J. Oncol."},{"issue":"5","key":"R10-150-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg."},{"issue":"1","key":"R11-150-20260325","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-019-2253-y","article-title":"Advanced primary urethral cancer: a case report","volume":"13","author":"Chen,","year":"2019","journal-title":"J. Med. Case Rep."},{"issue":"19","key":"R12-150-20260325","article-title":"A challenging surgical approach to locally advanced primary urethral carcinoma: a case report and literature review","volume":"95","author":"Lucarelli,","year":"2016","journal-title":"Medicine (United States)"},{"issue":"3","key":"R13-150-20260325","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/bju.15095","article-title":"Primary urethral cancer: treatment patterns and associated outcomes","volume":"126","author":"Mano,","year":"2020","journal-title":"BJU Int."},{"key":"R15-150-20260325","first-page":"50","article-title":"Primary urethral carcinoma in a bitch - multimodal treatment","author":"de Paiva,","year":"2022","journal-title":"Acta Sci. Vet."},{"issue":"1","key":"R16-150-20260325","doi-asserted-by":"crossref","DOI":"10.1186\/s12301-024-00413-6","article-title":"Combined surgical and chemotherapy treatment for invasive primary urethral cancer: a case presentation","volume":"30","author":"Simsek,","year":"2024","journal-title":"Afr. J. Urol."},{"issue":"1","key":"R17-150-20260325","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-020-02553-z","article-title":"Urethral cancer managed with phallus preserving surgery: a case report","volume":"15","author":"Walsh,","year":"2021","journal-title":"J. Med. Case Rep."},{"key":"R18-150-20260325","article-title":"Penile preservation for male urethral cancer","volume":"4","author":"Mohsen,","year":"2011","journal-title":"Shahid Iran J. Cancer Prev."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225001695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225001695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:24:47Z","timestamp":1774434287000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.110983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":16,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.110983","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-08-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}