{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:12:24Z","timestamp":1774444344350,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Schwannomas are benign tumors originating from Schwann cells, responsible for myelin sheath formation around peripheral nerves. Although primarily found in the head and neck, submandibular gland schwannomas are exceedingly rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>This report details a 39-year-old male with progressively enlarging neck swelling over three months, associated with mild pain during eating. Physical examination revealed a firm, non-tender swelling, and radiological investigation through ultrasound showed a large, well-defined hypoechoic lesion in the right submandibular fossa. Fine-needle aspiration cytology initially suggested sialadenosis due to the presence of grape-like clusters of salivary gland acini in a hemorrhagic background. The patient underwent local excision of the tumor and submandibular gland, with histopathological examination confirming the diagnosis of schwannoma. The tumor exhibited characteristic Antoni A and B areas and Verocay bodies, with strong S100 positivity on immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>This case underscores the challenge of diagnosing schwannomas in the submandibular region, where FNAC and ultrasonography may be inadequate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MRI and histopathology are crucial for accurate diagnosis, differentiating schwannomas from other submandibular swellings such as pleomorphic adenomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.110995","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T17:39:19Z","timestamp":1738258759000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Submandibular schwannoma - A diagnostic dilemma: A rare case report"],"prefix":"10.1097","volume":"127","author":[{"given":"Anu","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charanjeet","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-157-20260325","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1007\/s12070-020-01888-9","article-title":"Ancient schwannoma: cervical sympathetic chain with review of literature","volume":"74","author":"Verma,","year":"2022","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"R2-157-20260325","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009134","article-title":"\u201cAncient\u201d schwannoma of the submandibular gland: a case report and literature review","volume":"96","author":"Ho,","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"R3-157-20260325","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi,","year":"2023","journal-title":"Int. J. Surg. Lond. Engl."},{"key":"R4-157-20260325","article-title":"Schwannoma of the submandibular gland: a rare case report","volume":"10","author":"Ranjan,","year":"2016","journal-title":"J. Clin. Diagn. 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Case Rep."},{"key":"R11-157-20260325","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/modpathol.2014.109","article-title":"Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas","volume":"28","author":"Pekmezci,","year":"2015","journal-title":"Mod. Pathol."},{"key":"R12-157-20260325","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1038\/s41598-021-84319-1","article-title":"The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas","volume":"11","author":"Park,","year":"2021","journal-title":"Sci. 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