{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:23:36Z","timestamp":1781112216375,"version":"3.54.1"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Wilms tumor (WT), or nephroblastoma, is a rare pediatric renal malignancy with generally favorable outcomes after multimodal treatment. However, survivors face a risk of developing secondary malignant neoplasms (SMNs), though these are relatively uncommon. This report details a rare case of a secondary germ cell tumor of the ovary occurring in an 11-year-old girl, eight years post-treatment for stage III WT. The case underscores the importance of extended surveillance in WT survivors for detecting late-onset SMNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>An 11-year-old girl, previously treated for stage III WT with nephrectomy, chemotherapy, and abdominal radiotherapy, presented with abdominal distension. Physical examination revealed a palpable abdominal mass. Imaging studies, including ultrasound and CT scan, identified a large heterogeneous ovarian mass with cystic and necrotic areas, suggestive of malignancy. The mass was surgically excised, and histopathology confirmed a stage III germ cell tumor of the ovary. Due to metastasis to the omentum and lungs, additional surgical interventions, including supracervical hysterectomy and bilateral salpingo-oophorectomy, were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This case highlights the potential for late-onset SMNs in WT survivors, particularly in patients with a family history of malignancies, emphasizing the need for long-term follow-up beyond the typical five-year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The delayed appearance of secondary malignancies points to the necessity of multidisciplinary management and vigilant, prolonged surveillance to optimize outcomes for WT survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111107","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T12:12:03Z","timestamp":1741003923000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Secondary ovarian germ cell tumor following Wilms tumor after eight years post-treatment: A rare case report"],"prefix":"10.1097","volume":"128","author":[{"given":"Shahla","family":"Ansari-Damavandi","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeganeh","family":"Pakbaz","sequence":"additional","affiliation":[{"name":"Breast Health & Cancer Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Zarei","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Shadani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"6","key":"R1-112-20260325","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/bjc.1990.432","article-title":"International variations in the incidence of childhood renal tumours","volume":"62","author":"Stiller,","year":"1990","journal-title":"Br. 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