{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:40:18Z","timestamp":1776980418135,"version":"3.51.4"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Retroperitoneal liposarcomas are rare malignant tumors that often present asymptomatically until advanced stages. Giant liposarcomas exceeding 30 cm are particularly uncommon, and colonic infiltration causing gastrointestinal bleeding is extremely rare, with only a few cases documented in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 78-year-old female presented with hematochezia, constipation, and diffuse abdominal pain. Imaging revealed a large left para-aortic retroperitoneal mass compressing the colon. Colonoscopy showed colonic mucosal atrophy without active bleeding. Surgical exploration via midline laparotomy identified a bilobulated 89 \u00d7 35 \u00d7 40 cm retroperitoneal mass, infiltrating the left colon and compromising adjacent structures. En bloc resection, including hemicolectomy and left salpingo-oophorectomy, was performed. Histopathology confirmed a dedifferentiated liposarcoma with well-differentiated areas and colonic invasion reaching the muscularis propria. Margins were positive (R1). The patient recovered well postoperatively and experienced a single episode of intestinal obstruction at 6 months, resolved medically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Retroperitoneal liposarcomas typically exhibit compressive behavior rather than invasion. However, dedifferentiation is associated with aggressive features, including local invasion and higher recurrence rates. Colonic infiltration by giant liposarcomas is exceedingly rare, with only three additional cases reported. Mechanisms of bleeding include mucosal ischemia, compression, or direct histological infiltration, as observed in this case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The relationship between gastrointestinal bleeding and colonic infiltration in retroperitoneal liposarcomas may reflect the association between tumor dedifferentiation and invasive behavior. This underscores the importance of curative-intent surgical management as the primary therapeutic strategy, despite the challenge posed by the proximity to critical neurovascular structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111142","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T21:19:26Z","timestamp":1741814366000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Giant retroperitoneal liposarcoma with colonic infiltration as a cause of gastrointestinal bleeding: Case report and literature review"],"prefix":"10.1097","volume":"129","author":[{"given":"Sebastian","family":"Forero-Escobedo","sequence":"first","affiliation":[{"name":"Faculty of Medicine, National University of Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Milena","family":"Gonzalez-Rodriguez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National University of Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Alejandro","family":"Ram\u00edrez-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pontifical Xavierian University, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Alejandra","family":"Garcia-Bernal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National University of Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Polanco-Perdomo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pontifical Xavierian University, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Echeverri-Torrents","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pontifical Xavierian University, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"11","key":"R1-40-20260423","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/j.radcr.2022.07.107","article-title":"Giant retroperitoneal low grade liposarcoma with left kidney displacement: a case report","volume":"17","author":"Trajkovski,","year":"2022","journal-title":"Radiol Case Rep."},{"issue":"21","key":"R2-40-20260423","first-page":"e919245","article-title":"A multi-modality treatment of retroperitoneal de-differentiated liposarcoma","volume":"2","author":"Horowitz,","year":"2020","journal-title":"Am J Case Rep."},{"issue":"1","key":"R3-40-20260423","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12882-024-03701-z","article-title":"Giant retroperitoneal liposarcoma with multiple organ involvement: a case report and literature review","volume":"25","author":"Sun,","year":"2024","journal-title":"BMC Nephrol."},{"issue":"44","key":"R4-40-20260423","doi-asserted-by":"crossref","first-page":"101088","DOI":"10.1016\/j.gore.2022.101088","article-title":"Giant retroperitoneal dedifferentiated liposarcoma mimicking ovarian cancer: a case report","volume":"18","author":"Tani,","year":"2022","journal-title":"Gynecol Oncol Rep."},{"issue":"4","key":"R5-40-20260423","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/jjco\/hyu009","article-title":"Retroperitoneal liposarcoma with colonic involvement: a case report","volume":"44","author":"Sato,","year":"2014","journal-title":"Jpn. 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