{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:47:48Z","timestamp":1772639268638,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ewing sarcoma (ES) is a rare malignant tumour primarily affecting adolescents, typically involving the axial and appendicular skeleton. Its occurrence in the hand is exceedingly rare, comprising less than 1 % of all cases. Early diagnosis is often challenging due to its nonspecific symptoms and similarities to other conditions. This case report highlights a rare presentation of Ewing sarcoma in the hand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>A 20-year-old male presented with a six-month history of swelling and discomfort in the left thumb, without prior injury or inflammatory symptoms. Physical examination revealed a firm, non-tender, fusiform swelling involving the proximal and distal phalanges. Radiographic imaging showed a mass affecting the bone, with signs of periosteal reaction and cortical disruption. MRI revealed a well-demarcated soft tissue mass contacting the flexor tendon, skin, and neurovascular bundle, with bone involvement. Potential differential diagnoses included giant cell tumour, enchondroma, and aneurysmal bone cyst. Following consent, thumb amputation was performed, revealing a grey tumour surrounding the bone and soft tissues. Histopathological analysis revealed monomorphic small round cells with finely split chromatin and CD99 positivity which confirmed Ewing's sarcoma. Postoperative chemotherapy included Vincristine, Ifosfamide, Doxorubicin, Etoposide, and Actinomycin-D. After one year of follow-up, there was no evidence of recurrence or metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Ewing sarcoma of the hand is rare, often misdiagnosed as benign conditions or infection due to its soft tissue presentation and bone involvement. Timely diagnosis and surgical intervention, followed by chemotherapy, are crucial for effective treatment. The prognosis for hand Ewing sarcoma is favourable with early treatment, and survival rates for localized disease are around 70\u201380 %.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Importance of early suspicion in atypical soft tissue swellings of the hand in young adults is crucial. Ewing sarcoma in the hand, although rare, should be considered in young patients presenting with unexplained soft tissue masses. Early detection and a multidisciplinary approach involving surgery and chemotherapy can lead to favourable outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111379","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:23:59Z","timestamp":1745580239000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Ewing sarcoma of the hand: A rare case report with diagnostic and management considerations"],"prefix":"10.1097","volume":"131","author":[{"given":"Sheikh Sarfraz","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd. Fahud","family":"Khurram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimisha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishir","family":"Anand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"2","key":"R1-61-20260304","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1470-2045(09)70286-4","article-title":"Ewing's sarcoma","volume":"11","author":"Balamuth","year":"2010","journal-title":"Lancet Oncol"},{"issue":"2","key":"R4-61-20260304","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12593-010-0016-5","article-title":"Ewing's sarcoma of the hand: a case report","volume":"2","author":"Rajappa","year":"2010","journal-title":"J. Hand Microsurg"},{"key":"R5-61-20260304","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.otsr.2011.06.012","article-title":"Ewing's sarcoma of the finger: report of two cases and literature review","volume":"98","author":"Baccari","year":"2012","journal-title":"Orthop. Traumatol. Surg. Res"},{"issue":"5","key":"R6-61-20260304","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int J Surg Lond Engl"},{"issue":"4","key":"R7-61-20260304","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.anplas.2004.01.006","article-title":"Ewing sarcoma of the thumb: report of a case and review of the literature","volume":"49","author":"Seroussi","year":"2004","journal-title":"Ann. Chir. Plast. Esthet"},{"key":"R8-61-20260304","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/276463","article-title":"Mesenchymal stem cells and the origin of Ewing's sarcoma","volume":"2011","author":"Lin","year":"2011","journal-title":"Sarcoma"},{"issue":"2","key":"R9-61-20260304","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0033-8389(22)02860-3","article-title":"Ewing's sarcoma","volume":"31","author":"Eggli","year":"1993","journal-title":"Radiol. Clin. North Am"},{"issue":"9","key":"R10-61-20260304","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0046-8177(83)80300-1","article-title":"Ewing's sarcoma of bone: clinicopathologic aspects of 303 cases from the Intergroup Ewing's Sarcoma Study","volume":"14","author":"Kissane","year":"1983","journal-title":"Hum. Pathol"},{"issue":"4","key":"R11-61-20260304","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0363-5023(09)90033-8","article-title":"Ewing's sarcoma of the hand: localization and treatment","volume":"15","author":"Euler","year":"1990","journal-title":"J. Hand. Surg. [Am.]"},{"issue":"1","key":"R12-61-20260304","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/1753193407087865","article-title":"Ewing's sarcoma of the distal phalanx of the little finger","volume":"33","author":"Jerome","year":"2008","journal-title":"J Hand Surg Eur"},{"issue":"3","key":"R13-61-20260304","first-page":"257","article-title":"Adjuvant chemotherapy in the treatment of sarcomas","volume":"93","author":"Fayette","year":"2006","journal-title":"Bull. Cancer"},{"issue":"2","key":"R14-61-20260304","first-page":"141s","article-title":"Ewing's sarcoma: towards a common protocol for adults and children","volume":"4","author":"Oberlin","year":"2000","journal-title":"Cancer Radiother"},{"issue":"8","key":"R15-61-20260304","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2106\/00004623-199807000-00011","article-title":"The histological response to chemotherapy as a predictor of oncological outcome of operative treatment of Ewing's sarcoma","volume":"80","author":"Wunder","year":"1998","journal-title":"J. Bone Joint Surg. Am"},{"issue":"27","key":"R16-61-20260304","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1200\/JCO.2014.59.5256","article-title":"Ewing sarcoma: current management and future approaches through collaboration","volume":"33","author":"Gaspar","year":"2015","journal-title":"J. Clin. Oncol"},{"issue":"20","key":"R17-61-20260304","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1200\/JCO.2009.22.9864","article-title":"Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial","volume":"28","author":"Ladenstein","year":"2010","journal-title":"J. Clin. Oncol"},{"issue":"3","key":"R18-61-20260304","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1148\/rg.333135005","article-title":"From the Radiologic-Pathologic Archives: Ewing sarcoma family of tumors: radiologic-pathologic correlation","volume":"33","author":"Murphey","year":"2013","journal-title":"Radiographics"},{"issue":"9","key":"R19-61-20260304","first-page":"1201","article-title":"High-dose chemotherapy and blood autologous stem-cell rescue compared with standard chemotherapy in localized high-risk Ewing sarcoma: results of the Euro-EWING99 randomized trial","volume":"19","author":"Whelan","year":"2018","journal-title":"Lancet Oncol"},{"issue":"4","key":"R20-61-20260304","first-page":"740","article-title":"Ewing's sarcoma of the thumb: a rare presentation with review of the literature","volume":"38","author":"Venkateswaran","year":"2013","journal-title":"J. Hand. Surg. [Am.]"},{"issue":"2","key":"R21-61-20260304","first-page":"244","article-title":"Ewing's sarcoma of the hand: a report on 11 cases treated with chemotherapy and surgery","volume":"33","author":"Bacci","year":"2007","journal-title":"Eur. J. Surg. Oncol"},{"key":"R22-61-20260304","article-title":"Ewing's sarcoma of the metacarpal: a rare case with local recurrence","volume":"2019","author":"Memon","year":"2019","journal-title":"Case Rep. Oncol. Med"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225005656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225005656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:05:40Z","timestamp":1772618740000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":20,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.111379","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}