{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:58:59Z","timestamp":1792796339482,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumour, with a rare complication of malignant transformation, often presenting as squamous cell carcinoma (SCC). Early detection is critical for improving outcomes, especially in younger patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 25-year-old para-2 female presented with a 6-month history of dull abdominal pain, swelling, appetite loss, and weight loss. Examination revealed a firm abdominopelvic mass, and ultrasound indicated a 15 \u00d7 12 cm adnexal mass. Staging laparotomy revealed a 20 \u00d7 15 cm left ovarian mass with ascitic fluid and enlarged para-aortic lymph nodes. Histopathological analysis confirmed keratinizing poorly differentiated SCC arising from MCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This case highlights the rarity of malignant transformation in MCTs, particularly in younger women. The absence of distinct symptoms and reliance on imaging necessitates a high index of suspicion for malignancy when evaluating ovarian masses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The patient underwent successful staging and surgery, followed by an initial chemotherapy regimen. However, she lost follow-up, emphasizing the challenge of maintaining care continuity in remote areas. Close monitoring and education regarding the importance of follow-up care are crucial for improving outcomes in such cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111403","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T02:36:35Z","timestamp":1746239795000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Squamous cell carcinoma arising from mature cystic teratoma of the ovary in a premenopausal women: A rare case report"],"prefix":"10.1097","volume":"131","author":[{"given":"Nigat Amsalu","family":"Addis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinfemicheal Tilahun","family":"Yigzaw","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bewketu Abebe","family":"Alemu","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassa Berie","family":"Zegeye","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyoel Negash","family":"Taddesse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getachew Shiferaw","family":"Yigezaw","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-85-20260304","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.gore.2016.12.005","article-title":"An ovarian mature cystic teratoma evolving in squamous cell carcinoma: a case report and review of the literature","volume":"19","author":"Goudeli","year":"2017","journal-title":"Gynecol. Oncol. Rep"},{"issue":"12","key":"R2-85-20260304","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S1470-2045(08)70306-1","article-title":"Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data","volume":"9","author":"Hackethal","year":"2008","journal-title":"Lancet Oncol"},{"issue":"1","key":"R3-85-20260304","article-title":"Squamous cell carcinoma arising in a mature cystic teratoma","volume":"2012","author":"Avc\u0131","year":"2012","journal-title":"Case Rep. Obstet. Gynecol"},{"issue":"1","key":"R4-85-20260304","doi-asserted-by":"crossref","DOI":"10.1136\/ijgc-00009577-200601000-00023","article-title":"Malignant transformation of ovarian mature cystic teratoma","volume":"16","author":"Rim","year":"2006","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"1","key":"R5-85-20260304","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5387\/fms.2019-31","article-title":"Malignant transformation arising from mature cystic teratoma of the ovary presenting as ovarian torsion: a case report and literature review","volume":"66","author":"Toba","year":"2020","journal-title":"Fukushima J. Med. Sci"},{"issue":"1","key":"R6-85-20260304","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13256-024-04465-8","article-title":"Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature","volume":"18","author":"Jafari-Nozad","year":"2024","journal-title":"J. Med. Case Rep"},{"issue":"4","key":"R7-85-20260304","first-page":"195","article-title":"Ovarian squamous cell carcinoma arising from mature cystic teratoma: a case report","volume":"7","author":"Zaboli","year":"2022","journal-title":"Case Rep. Clin. Pract"},{"key":"R8-85-20260304","article-title":"Squamous cell carcinoma arising from mature cystic teratoma of the ovary: a case report","volume":"12","author":"Xu","year":"2024","journal-title":"SAGE Open Med. Case Rep"},{"key":"R9-85-20260304","first-page":"1","article-title":"Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review","volume":"19","author":"Li","year":"2019","journal-title":"BMC Cancer"},{"issue":"1","key":"R10-85-20260304","first-page":"37","article-title":"Squamous cell carcinoma of the ovary arising in a mature cystic teratoma in a 28-year-old female: a case report and review of literature","volume":"14","author":"Shaffi","year":"2022","journal-title":"Southern Afr. J. Gynaecol. Oncol"},{"issue":"5","key":"R11-85-20260304","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/JS9.0000000000000373","article-title":"The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"109","author":"Sohrabi","year":"2023","journal-title":"Int. J. Surg"},{"issue":"5","key":"R12-85-20260304","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.21873\/anticanres.13372","article-title":"Clinical outcome of patients with malignant tumors associated with mature cystic teratomas of the ovary: a retrospective multicenter Italian study","volume":"39","author":"Gadducci","year":"2019","journal-title":"Anticancer Res"},{"issue":"38","key":"R13-85-20260304","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000030667","article-title":"Squamous cell carcinoma in mature cystic teratoma of the ovary induced by human papillomavirus 16 infection: a case report and literature review","volume":"101","author":"Shi","year":"2022","journal-title":"Medicine"},{"issue":"7","key":"R14-85-20260304","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.3390\/ijms24076141","article-title":"Mature cystic teratoma: an integrated review","volume":"24","author":"Cong","year":"2023","journal-title":"Int. J. Mol. Sci"},{"key":"R15-85-20260304","article-title":"Incidental diagnosis of squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a case report and review of literature","volume":"10","author":"Dorji","year":"2022","journal-title":"SAGE Open Med. Case Rep"},{"issue":"12","key":"R16-85-20260304","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1111\/jog.15409","article-title":"Malignant transformation of mature cystic teratoma of the ovary","volume":"48","author":"Atwi","year":"2022","journal-title":"J. Obstet. Gynaecol. Res"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225005899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225005899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:06:25Z","timestamp":1772618785000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":16,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.111403","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}