{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:48:16Z","timestamp":1772639296553,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Brain metastases are the most common intracranial tumors in adults, yet they remain rare in sarcoma patients, occurring in &lt;6 % of cases. Metastatic spread of sarcomas typically involves the lungs, bones, and liver, with brain involvement being an unusual and poorly understood occurrence. Given the limited data, management strategies remain challenging, and prognosis is generally poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A previously healthy 16-year-old female presented with left shoulder pain and restricted movement. Imaging revealed a pathological fracture of the proximal humerus with a destructive mass lesion, and biopsy confirmed a diagnosis of high-grade sarcoma. She underwent chemotherapy, tumor resection, and later a pneumonectomy for lung metastases. Thirty months post-diagnosis, she developed progressive left-sided weakness, and brain MRI demonstrated a right insular metastatic lesion. She underwent gross total resection via microscopic right pterional craniotomy, followed by whole-brain radiotherapy and rehabilitation. At 42 months post-diagnosis, she remained recurrence-free with stable neurological function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Brain metastases from sarcomas are rare and associated with poor prognosis. Pulmonary metastases are the strongest risk factor, and survival remains limited despite treatment. Surgical resection improves neurological function and extends survival in select patients with a high Karnofsky Performance Scale score and controlled systemic disease. Stereotactic radiosurgery is an option for multiple lesions, while WBRT and chemotherapy are reserved for widespread disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case highlights the potential for favorable outcomes in sarcoma brain metastases with a multidisciplinary approach. Early detection and tailored intervention may improve survival and quality of life in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111410","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:51:45Z","timestamp":1746499905000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A rare case report of insular metastatic from sarcoma with successful long term surgical and oncological management"],"prefix":"10.1097","volume":"131","author":[{"given":"Hamza A.","family":"Abdul-Hafez","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman","family":"Aljouda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Al-Makassed Hospital, Jerusalem, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Aldarwish","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Al-Makassed Hospital, Jerusalem, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashar N.","family":"Soubh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Al-Makassed Hospital, Jerusalem, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Najar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Al-Makassed Hospital, Jerusalem, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoun","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Al-Makassed Hospital, Jerusalem, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"2","key":"R1-91-20260304","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1227\/00006123-199408000-00002","article-title":"Sarcoma metastatic to the brain: results of surgical treatment","volume":"35","author":"Bindal","year":"1994","journal-title":"Neurosurgery"},{"issue":"4","key":"R2-91-20260304","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0090-3019(97)00034-7","article-title":"Sarcoma metastatic to the brain: a series of 15 cases","volume":"49","author":"Salvati","year":"1998","journal-title":"Surg. 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A presentation of 12 cases, a review of the literature, and a discussion of possible changing patterns with the use of chemotherapy, placing special emphasis on embryonal tumours","volume":"16","author":"Bryant","year":"1980","journal-title":"Eur. J. Cancer (1965)"},{"key":"R6-91-20260304","doi-asserted-by":"crossref","first-page":"18271","DOI":"10.1007\/s00432-023-05451-1","article-title":"Brain metastases of sarcoma: a rare phenomenon in rare tumours","volume":"149","author":"J\u0119drys","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol"},{"issue":"5","key":"R7-91-20260304","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/1097-0142(197511)36:5<1843::AID-CNCR2820360541>3.0.CO;2-V","article-title":"Increased incidence of cerebral metastases in sarcoma patients with prolonged survival from chemotherapy. 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