{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:48:19Z","timestamp":1772639299869,"version":"3.50.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Infantile fibrosarcoma (IFS) is a rare soft tissue malignancy that primarily affects children under one year of age. Its clinical and radiologic features often resemble benign vascular tumors like hemangiomas, making diagnosis challenging. Early and accurate identification is essential for effective management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report a case of a 3-year-old child with a progressively enlarging mass in the left upper limb. Clinical examination revealed a firm, non-pulsatile mass with prominent venous collateral circulation. Doppler ultrasound and MRI findings suggested an infantile hemangioma. Surgical excision revealed a highly vascularized tumor closely associated with the brachial artery and median nerve. Histopathological analysis confirmed infantile fibrosarcoma, characterized by spindle-shaped cells with mild atypia, high mitotic activity, hemosiderin deposits, and significant vascular proliferation. Immunohistochemistry was negative for myogenin, cytokeratin, desmin, CD68, and TLE1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>This case underscores the diagnostic challenge posed by IFS, which can closely mimic infantile hemangioma on imaging. MRI findings suggested but did not confirm the diagnosis. Histopathology remains the definitive method for diagnosis. Multidisciplinary management\u2014including surgical resection and, when indicated, chemotherapy\u2014is essential for optimal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IFS should be considered in the differential diagnosis of congenital soft tissue masses, particularly when atypical features are present. Definitive diagnosis relies on histopathological and immunohistochemical evaluation. Multidisciplinary management plays a critical role in ensuring favorable clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111417","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:08:39Z","timestamp":1746778119000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Infantile fibrosarcoma of the left upper limb mimicking a hemangioma: A case report"],"prefix":"10.1097","volume":"131","author":[{"given":"Hafedh","family":"Daly","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Monastir University Hospital, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiez","family":"Boughanmi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Monastir University Hospital, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Zayati","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Monastir University Hospital, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leith","family":"Limayem","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Monastir University Hospital, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ali","family":"Chaouch","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Monastir University Hospital, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fethi","family":"Jebali","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care B, Monastir University Hospital, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"3","key":"R1-98-20260304","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpeds.2006.12.003","article-title":"Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics","volume":"150","author":"Haggstrom","year":"2007","journal-title":"J. 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