{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:31:34Z","timestamp":1773304294611,"version":"3.50.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Eosinophilic Angiocentric Fibrosis (EAF) is a rare inflammatory condition affecting the upper respiratory and sinonasal tracts. This study aims to elaborate on the clinical and pathological features of a patient with extensive, rare EAF involving the sinonasal tract, subglottic region, and orbit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A fifty-five-year-old female patient with a known case of bronchial asthma, hypothyroidism, and IgG-4-related necrotizing blepharitis presented to our clinic with a 14-year history of bilateral nasal obstruction and post-nasal drip despite medical and surgical intervention. Rhinoscopy revealed fibrosis and adhesion of the nasal cavity and nasopharynx, along with grade I subglottic stenosis. Functional endoscopic sinus surgery was performed to relieve her symptoms and obtain a specimen confirming the diagnosis of EAF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Given the wide variety of differential diagnoses for bilateral nasal obstruction, imaging and histopathological evaluation are necessary to diagnose EAF. The characteristic onion-skin pattern reflecting the perivascular eosinophil-rich inflammatory infiltrate with subsequent concentric fibrosis is the gold standard in diagnosing these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Despite advancements in clinical practice, a clear management guideline for patients with EAF has not yet been established. In our paper, we pool our management approach with the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111433","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T07:50:23Z","timestamp":1747122623000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilic angiocentric fibrosis: A case report and a review of the literature"],"prefix":"10.1097","volume":"132","author":[{"given":"Jood K.","family":"Alotaibi","sequence":"first","affiliation":[{"name":"College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghad A.","family":"Alkhaldi","sequence":"additional","affiliation":[{"name":"College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naif H.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Mumtaz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas M.","family":"Dababo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"9","key":"R1-6-20260311","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/alr.21347","article-title":"Sinonasal eosinophilic angiocentric fibrosis: a systematic review","volume":"4","author":"Fang","year":"2014","journal-title":"Int. Forum Allergy Rhinol"},{"issue":"9","key":"R2-6-20260311","doi-asserted-by":"crossref","DOI":"10.1177\/03000605221126039","article-title":"Eosinophilic angiocentric fibrosis of the sinonasal tract: a case report and review of the literature","volume":"50","author":"Javadirad","year":"2022","journal-title":"J. Int. Med. Res"},{"issue":"5","key":"R3-6-20260311","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.anorl.2017.02.012","article-title":"Right ethmoid eosinophilic angiocentric fibrosis with orbital extension","volume":"134","author":"Gorostis","year":"2017","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis"},{"issue":"S3","key":"R4-6-20260311","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s12070-018-1453-x","article-title":"Nasal framework reconstruction in patient with eosinophilic angiocentric fibrosis","volume":"71","author":"Sazgar","year":"2018","journal-title":"Indian J. Otolaryngol. 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