{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:34:10Z","timestamp":1773498850248,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors with histological and immunophenotypic characteristics of perivascular epithelioid cells, characterized by smooth muscle and melanocytic markers. Herein, we report a case of PEComa originating in the thyroid gland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 36-year-old woman presented with a thyroid nodule detected on physical examination that gradually enlarged during a 3-year follow-up period. The patient underwent a unilateral thyroidectomy after completing the relevant preoperative investigations. Postoperative pathological immunohistochemical staining was positive for cathepsin K, microphthalmia-associated transcription factor (MiTF), and smooth muscle actin (SMA). The patient was diagnosed with a perivascular epithelioid tumor. The patient's condition stabilized after a short-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Perivascular epithelioid cell tumors (PEComas) of the thyroid gland are extremely rare, with only one case reported in the literature. There are no clear criteria for distinguishing benign and malignant PEComas of the thyroid gland. This case suggests that surgical resection is a good management option for this patient, and long-term follow-up is needed to observe the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Surgical resection is safe and feasible for PEComas of the thyroid gland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111464","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T12:06:05Z","timestamp":1747915565000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Thyroid perivascular epithelioid cell tumor: A rare case report"],"prefix":"10.1097","volume":"132","author":[{"given":"Wenqing","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binshen","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"3","key":"R1-26-20260311","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5604\/16652681.1198822","article-title":"Primary hepatic perivascular epithelioid tumor (PEComa)","volume":"15","author":"Schaeffer","year":"2016","journal-title":"Ann. 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Cancer"},{"issue":"3","key":"R9-26-20260311","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s12105-022-01428-7","article-title":"Primary mesenchymal tumors of the thyroid gland: a modern retrospective cohort including the first case of TFE3-translocated malignant perivascular epithelioid cell tumor (PEComa)","volume":"16","author":"Zhang","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"7","key":"R10-26-20260311","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/PAS.0000000000002218","article-title":"TFE3 -rearranged PEComa\/PEComa-like neoplasms : report of 25 new cases expanding the clinicopathologic spectrum and highlighting its association with prior exposure to chemotherapy","volume":"48","author":"Argani","year":"2024","journal-title":"Am. J. Surg. 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