{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:35:57Z","timestamp":1781577357593,"version":"3.54.5"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Neuroendocrine neoplasms (NENs) of the appendix are rare in children even though they are the second commonest gastrointestinal tumor next to lymphoma. NENs are usually diagnosed incidentally in appendectomies done for appendicitis, occasionally resulting in a second operation to ensure adequacy of the management. This case report is aimed at emphasizing the significance of subjecting any appendectomy specimen to histopathologic examination, irrespective of the indication for appendectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>Here we presented a case of a 14-year-old male adolescent who presented with right lower quadrant abdominal pain of 16 h duration. He had leukocytosis with left shift, and the abdominal ultrasound examination concluded acute appendicitis, for which an emergency appendectomy was done. The histopathologic examination of the appendix along with the immunohistochemistry findings for synaptophysin concluded well differentiated neuroendocrine tumor WHO grade 1, AJCC stage PT3NxMx. Subsequent right hemicolectomy with lymphadenectomy was done due to the stage of the tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Appendiceal NENs are extremely uncommon in the global pediatric population and have benign behavior. The tip of the appendix is the commonest site of origin. Surgery is the mainstay of treatment, and size is the most determinant factor in determining the extent of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Since most appendiceal neuroendocrine tumors are diagnosed incidentally, every appendectomy tissue should be submitted for histopathologic examination to identify the presence of a tumor and determine its stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111474","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T19:36:38Z","timestamp":1748979398000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A case of well-differentiated neuroendocrine tumor of the appendix in a 14-year-old male adolescent clinically presented with features of acute appendicitis: A case report and literature review"],"prefix":"10.1097","volume":"132","author":[{"given":"Birhanu Kassie","family":"Reta","sequence":"first","affiliation":[{"name":"Aksum University, College of Health Science, Department of Pathology, Aksum, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yordanos Birhane","family":"Gebrecherkos","sequence":"additional","affiliation":[{"name":"Aksum University, College of Health Science, School of Medicine, Aksum, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemane Leake","family":"Gebremichael","sequence":"additional","affiliation":[{"name":"Aksum University, College of Health Science, Department of Pediatrics and Child Health, Aksum, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hindeya Hailu","family":"Hagos","sequence":"additional","affiliation":[{"name":"Aksum University, College of Health Science, Department of Pediatrics and Child Health, Aksum, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demelash Darota","family":"Dojamo","sequence":"additional","affiliation":[{"name":"Addis Ababa University, College of Health Science, Department of Pathology, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seblewengel Maru","family":"Wubalem","sequence":"additional","affiliation":[{"name":"Wachemo University, College of Health Science, Department of Pathology, Hosana, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"12","key":"R1-36-20260311","doi-asserted-by":"crossref","DOI":"10.3390\/children10121899","article-title":"Incidence and management of appendiceal neuroendocrine tumors in pediatric population: a bicentric experience with 6285 appendectomies","volume":"10","author":"Pogoreli\u0107","year":"2023","journal-title":"Children"},{"key":"R2-36-20260311","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s11864-023-01093-0","article-title":"An update on appendiceal neuroendocrine tumors","volume":"24","author":"Andrini","year":"2023","journal-title":"Curr. Treat. Options in Oncol"},{"key":"R3-36-20260311","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejso.2022.10.021","article-title":"Management and outcome of high-risk neuroendocrine tumors of the appendix in children; a systematic review","volume":"49","author":"van Amstel","year":"2023","journal-title":"Eur. J. Surg. Oncol"},{"key":"R4-36-20260311","doi-asserted-by":"crossref","DOI":"10.1097\/MPH.0000000000000598","article-title":"Neuroendocrine tumor of the appendix in children","volume":"39","author":"Wu","year":"2017","journal-title":"J. Pediatr. Hematol. Oncol"},{"key":"R6-36-20260311","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4274\/tjcd.galenos.2024.2024-6-1","article-title":"Management and long-term follow-up outcomes of appendiceal neuroendocrine tumor patients: evaluation of single-center data","author":"Akay","year":"2024","journal-title":"Turk. J. Colorectal Dis"},{"key":"R7-36-20260311","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjz086","article-title":"Neuroendocrine tumor of the appendix'a case report and review of the literature","volume":"2019","author":"Morais","year":"2019","journal-title":"J. Surg. Case Rep"},{"issue":"5","key":"R9-36-20260311","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-0038-1642051","article-title":"Appendiceal neoplasms","volume":"31","author":"Hatch","year":"2018","journal-title":"Clin. Colon Rectal Surg"},{"issue":"2","key":"R10-36-20260311","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2022.11458","article-title":"An unusual case of appendicitis due to appendiceal neuroendocrine tumor in a patient: a case report","volume":"24","author":"Gao","year":"2022","journal-title":"Exp. Ther. Med"},{"issue":"1","key":"R11-36-20260311","doi-asserted-by":"crossref","DOI":"10.1186\/s12893-023-02183-4","article-title":"Incidence of appendiceal neoplasms in appendectomy patients","volume":"23","author":"N\u00fa\u00f1ez-Rocha","year":"2023","journal-title":"BMC Surg"},{"key":"R12-36-20260311","article-title":"Revised surgical CAse REport (SCARE) guideline: an update for the age of artificial intelligence","volume":"10","author":"Kerwan","year":"2025","journal-title":"Premier Journal of Science"},{"issue":"20","key":"R13-36-20260311","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16203440","article-title":"Characteristics and management of children with appendiceal neuroendocrine neoplasms: a single-center study","volume":"16","author":"Mastrangelo","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"43","key":"R14-36-20260311","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.amsu.2019.05.015","article-title":"Incidental neuro-endocrine tumor of the appendix: case report and literature review","author":"Elkbuli","year":"2019","journal-title":"Ann. 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Trauma Acute Care Surg"},{"key":"R22-36-20260311","first-page":"601","article-title":"Neuroendocrine neoplasms of the Appendix: a review of the literature","volume":"38","author":"Tsilimigras","year":"2018","journal-title":"Anticancer Res"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225006601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225006601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:01:13Z","timestamp":1773237673000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":19,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.111474","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}