{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:59:06Z","timestamp":1773215946793,"version":"3.50.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Triple-negative breast cancer (TNBC) is highly invasive and poorly responsive to standard treatments, making it prone to brain metastasis, which exhibits significant intracranial invasiveness. But brain metastasis is extremely rare within one month after neoadjuvant therapy and standard modified radical surgery. Here, we report a case of a patient who, after completing neoadjuvant chemotherapy and achieving partial remission (PR), was diagnosed with brain metastasis one month post-surgery. The uniqueness of this case lies in the imaging description of a 2 cm mass, which was similarly palpable on physical examination. However, at the initial detection, skin invasion and lymph node metastasis on the ipsilateral clavicle were also identified, indicating highly aggressive behavior. For such highly invasive cases, intensified neoadjuvant therapy and close monitoring should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>We report a female patient who despite achieving a partial response (PR) after neoadjuvant chemotherapy was found to have brain metastatic lesions due to obvious symptoms of meningeal metastasis only one month after surgery. The patient's meningeal metastasis remained stable only after undergoing whole-brain radiotherapy and intrathecal injection of chemotherapy drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Supraclavicular lymph node metastasis is a high - risk factor for metastasis in triple - negative breast cancer. Effective neoadjuvant therapy is a factor contributing to a favorable prognosis. This patient exhibits both of these characteristics. For this particular patient, a head MRI may enable earlier detection of brain metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For high - risk triple - negative breast cancer patients, the risk of brain metastasis should be closely monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111574","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:41:14Z","timestamp":1751384474000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Ultra-rapid meningeal metastasis in triple-negative breast cancer: A case report"],"prefix":"10.1097","volume":"133","author":[{"given":"Naiqian","family":"Zhang","sequence":"first","affiliation":[{"name":"Breast Surgery Department, Jilin Cancer Hospital, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Breast Surgery Department, Jilin Cancer Hospital, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keru","family":"MA","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Gu","sequence":"additional","affiliation":[{"name":"Breast Surgery Department, Jilin Cancer Hospital, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Breast Surgery Department, Jilin Cancer Hospital, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Breast Surgery Department, Jilin Cancer Hospital, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"6797","key":"R1-73-20260310","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"NATURE"},{"key":"R2-73-20260310","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.2147\/CMAR.S252801","article-title":"Breast Cancer meningeal metastasis: the potential role of MRI beyond current clinical applications","volume":"12","author":"Hadjipanteli","year":"2020","journal-title":"Cancer Manag. Res"},{"key":"R3-73-20260310","article-title":"Revised surgical CAse REport (SCARE) guideline: an update for the age of artificial intelligence","volume":"10","author":"Kerwan","year":"2025","journal-title":"Premier Journal of Science"},{"issue":"3","key":"R4-73-20260310","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10549-016-3757-4","article-title":"Risk of regional recurrence in triple-negative breast cancer patients: a Dutch cohort study","volume":"156","author":"van Roozendaal","year":"2016","journal-title":"BREAST CANCER RES TR"},{"issue":"15","key":"R5-73-20260310","doi-asserted-by":"crossref","first-page":"e13128","DOI":"10.1200\/JCO.2018.36.15_suppl.e13128","article-title":"Patterns of recurrence in triple negative breast cancer patients (automated IHC) : An Indian Tertiary Care Center data","volume":"36","author":"Ghosh","year":"2018","journal-title":"J. Clin. Oncol"},{"issue":"4","key":"R6-73-20260310","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.4123","article-title":"Clinical and demographic factors, treatment patterns, and overall survival associated with rare triple-negative breast carcinomas in the US","volume":"4","author":"Elimimian","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"R7-73-20260310","first-page":"10 617593","article-title":"Clinicopathological characteristics and treatment strategies of triple-negative breast Cancer patients with a survival longer than 5 years. 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Oncol"},{"key":"R11-73-20260310","first-page":"12 1417366","article-title":"Development and validation of a nomogram for predicting rapid relapse in triple-negative breast cancer patients treated with neoadjuvant chemotherapy. Front cell","author":"Ma","year":"2024","journal-title":"Dev. 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