{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:59:28Z","timestamp":1773215968399,"version":"3.50.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease primarily affecting the neuromuscular system. Gastrointestinal manifestations are typically functional in nature, while mechanical obstructions are rarely reported. Meckel's diverticulum (MD), a congenital gastrointestinal anomaly, is often asymptomatic but can cause obstruction in rare adult cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>\n                      We present the case of a 30-year-old male with early-onset ALS who presented with signs of intestinal obstruction, including severe abdominal pain, vomiting, and obstipation. Imaging revealed a closed-loop small bowel obstruction. Emergency laparotomy identified a torsed Meckel's diverticulum as the underlying cause. Surgical resection was performed, and the postoperative course was managed with tracheostomy and PEG placement due to progressive ALS-related respiratory and swallowing impairment. The patient was successfully stabilized and discharged with ongoing multidisciplinary support\n                      <jats:italic toggle=\"yes\">.<\/jats:italic>\n                      The patient was discharged three weeks later in a stable condition and remains alive under multidisciplinary follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This case highlights the diagnostic challenge of distinguishing mechanical from functional gastrointestinal symptoms in patients with advanced ALS. While neurodegenerative progression often explains GI complaints in ALS, this case emphasizes the need to consider alternative etiologies, including surgical emergencies like MD-related obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mechanical small bowel obstruction due to Meckel's diverticulum in ALS is exceedingly rare. Timely diagnosis and intervention, supported by multidisciplinary perioperative care, are critical for favorable outcomes in this high-risk population. Despite significant ALS-related comorbidities, the patient's outcome was favorable with stable discharge and ongoing respiratory and nutritional support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111585","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:42:57Z","timestamp":1751427777000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Meckel's diverticulum in patient with early-onset ALS: A case report"],"prefix":"10.1097","volume":"133","author":[{"given":"El Mawla","family":"Zeinab","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pulmonary & Critical Care, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khazzaka","family":"Lynn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidar Ahmad","family":"Houssein","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rassoul Aazam Hospital, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"4","key":"R1-83-20260310","first-page":"246","article-title":"Komplikasyonlu Meckel Divertik\u00fclleri [Complicated Meckel's diverticulum]","volume":"9","author":"Ak\u00e7akaya,","year":"2003","journal-title":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES"},{"issue":"2","key":"R2-83-20260310","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000351153","article-title":"Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature","volume":"41","author":"Chi\u00f2","year":"2013","journal-title":"Neuroepidemiology"},{"key":"R3-83-20260310","doi-asserted-by":"crossref","first-page":"1552949","DOI":"10.3389\/fnins.2025.1552949","article-title":"The systemic inflammation markers as potential predictors of disease progression and survival time in amyotrophic lateral sclerosis","volume":"19","author":"Hong","year":"2025","journal-title":"Front. 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Meckel diverticulum: radiologic features with pathologic correlation","volume":"24","author":"Levy","year":"2004","journal-title":"Radiographics: A review publication of the Radiological Society of North America, Inc"},{"issue":"7-8","key":"R6-83-20260310","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/21678421.2020.1788095","article-title":"Characteristics of amyotrophic lateral sclerosis in Lebanon-a chart review","volume":"21","author":"Malek,","year":"2020","journal-title":"Amyotrophic lateral sclerosis & frontotemporal degeneration"},{"key":"R7-83-20260310","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijscr.2021.01.047","article-title":"Gallstone ileus in a patient with amyotrophic lateral sclerosis: a case report","volume":"79","author":"Marcucci","year":"2021","journal-title":"Int. J. Surg. Case Rep"},{"issue":"10","key":"R8-83-20260310","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/ene.14393","article-title":"Amyotrophic lateral sclerosis: a clinical review","volume":"27","author":"Masrori","year":"2020","journal-title":"Eur. J. Neurol"},{"key":"R9-83-20260310","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijscr.2015.09.013","article-title":"Unusual presentation of a Meckel's diverticulum: a case report","volume":"16","author":"Tenreiro","year":"2015","journal-title":"Int. J. Surg. Case Rep"},{"key":"R10-83-20260310","article-title":"Revised surgical CAse REport (SCARE) guideline: an update for the age of artificial intelligence","volume":"10","author":"Kerwan","year":"2025","journal-title":"Premier Journal of Science"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225007710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261225007710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:07:10Z","timestamp":1773137230000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2025.111585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2025.111585","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-04-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}