{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:55:28Z","timestamp":1773215728072,"version":"3.50.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Glial heterotopia (GH) is a rare congenital lesion characterized by the presence of normal glial tissue in extracranial sites with no connection to the central nervous system. Oropharyngeal occurrence is very rare. The aim of this case report is to emphasize that oropharyngeal glial heterotopia can present as a large mass causing airway obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>A 21-h-old female neonate presented with a protruding mass from the oral cavity since birth with associated respiratory distress and feeding problems. On examination she was in respiratory distress having supraclavicular and subcostal retraction, with a grey-white mass protruding through the mouth. A neurocranium CT scan revealed a cystic mass at the oropharynx measuring 5.4 cm \u00d7 4 cm. Transoral excision of the mass was done, and a subsequent histopathologic examination and immunohistochemistry for glial fibrillary acidic protein (GFAP) confirmed the diagnosis of glial heterotopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>GH most commonly involves the nose, although there are reports of its occurrence in the lips, tongue, scalp, and oropharynx. Preoperative imaging is essential to exclude intracranial connection. Complete excision is the treatment of choice, and histopathology provides a definitive diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Glial heterotopia can rarely occur in the oropharynx, and it can be unusually large to cause airway obstruction. Clinicians should consider glial heterotopia in newborns presenting with a cystic oropharyngeal mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111809","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:36:15Z","timestamp":1755243375000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A case of large oropharyngeal glial heterotopia causing airway obstruction in a newborn: A case report and brief review of literature"],"prefix":"10.1097","volume":"134","author":[{"given":"Birhanu Kassie","family":"Reta","sequence":"first","affiliation":[{"name":"Aksum university college of health science, Department of Pathology, Aksum, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andom Geremew","family":"Tesfay","sequence":"additional","affiliation":[{"name":"Aksum university college of health science, Department of Otolaryngology Head and neck surgery, Aksum, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizan Tsegaye","family":"Abebe","sequence":"additional","affiliation":[{"name":"Aksum university college of health science department of Pediatrics and child health, Aksum, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebiat Zerabiruk","family":"Embaye","sequence":"additional","affiliation":[{"name":"Aksum university college of health science, Department of Pathology, Aksum, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gebreyohans Tesfay","family":"Kidanu","sequence":"additional","affiliation":[{"name":"Aksum university college of health science, Department of Radiology, Aksum, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidaya Yahya","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Addis Ababa university college of health science, Department of Pathology, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"1","key":"R1-121-20260310","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/0970-0358.182244","article-title":"Glial heterotopia of the lip: a rare presentation","volume":"49","author":"Dadaci","year":"2016","journal-title":"Indian J. Plast. Surg"},{"key":"R2-121-20260310","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.18203\/2320-6012.ijrms20161994","article-title":"Glial heterotopia in head and neck, single center experience of 5 cases","author":"Arikeri","year":"2016","journal-title":"Int. J. Res. Med. Sci"},{"issue":"2","key":"R3-121-20260310","first-page":"13","article-title":"Parapharyngeal neuroglial heterotopia: a case report","author":"Saeidi","year":"2022","journal-title":"Iran. J. 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