{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:03:22Z","timestamp":1791047002726,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and importance:<\/jats:title>\n                    <jats:p>Bladder carcinoma encompasses various histological subtypes, with shadow cell differentiation (SCD) being an exceptionally rare occurrence, resembling cutaneous pilomatricoma. Herein, we report a case of bladder carcinoma with SCD and aim to elucidate its clinico-pathological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 67-year-old North African man, a heavy smoker, who presented with left lumbar pain, haematuria and dysuria. The physical examination revealed a hypogastric mass. Rectal examination was unremarkable. Radiological examination (Ultrasound and CT) showed a 3 cm bladder tumor, with a suspicious lung and mediastinal tumors. A complete transurethral resection of the bladder tumor (TURB) was performed. It showed high-grade urothelial carcinoma with partial squamous differentiation and SCD. Immunohistochemistry revealed positive \u03b2-catenin in the peripheral squamous component.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical discussion:<\/jats:title>\n                    <jats:p>Our findings highlight that SCD, a form of keratinization typically observed in the hair matrix, can also manifest in carcinomas with squamous components. The presence of SCD in these tumors suggests a variant of keratinization potentially linked to the squamous components within these neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We presented a case bladder carcinoma with SCD, underscoring its unique histopathological features and the importance of recognizing this rare variant for accurate diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2025.111867","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T14:25:07Z","timestamp":1756045507000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Bladder carcinoma with shadow cell differentiation: a case report with immunohistochemical analyses"],"prefix":"10.1097","volume":"135","author":[{"given":"Raja","family":"Jouini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Guesmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maissa Ben","family":"Thayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Amine","family":"Oueslati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aschraf","family":"Chadli-Debbiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-64-20260803","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.job.2022.03.005","article-title":"Ghost cells unveiled: a comprehensive review","volume":"64","author":"Garg","year":"2022","journal-title":"J. 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