{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:37:02Z","timestamp":1781883422099,"version":"3.54.5"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>\n                           <jats:bold>ABSTRACT<\/jats:bold>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction and importance:<\/jats:title>\n            <jats:p>Several neuro-ophthalmic manifestations have been reported with coronavirus disease 2019 (COVID-19) infection. However, isolated optic neuritis was infrequently reported in humans with COVID-19. If it occurred, optic neuritis was usually a part of a demyelinating syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation:<\/jats:title>\n            <jats:p>In this paper, we report a case of optic neuritis concomitant with an undiagnosed pituitary macroadenoma discovered during active COVID-19 infection. The case was a 33-year-old woman with infertility who was recently found to have a pituitary macroadenoma secreting prolactin. During active COVID-19 infection, the patient developed optic neuritis that responded well to corticosteroids. Brain imaging and hormonal profile negated the presence of any demyelinating disease or pituitary apoplexy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical discussion:<\/jats:title>\n            <jats:p>A dilemma of whether optic neuritis occurring concomitantly with pituitary macroadenoma is just a coincidence, or there is an association remains unresolved. Whether COVID-19 infection might precipitate optic neuritis in patients with pituitary macroadenoma or not remains an issue to be answered by observing data from future case reports about similar findings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Optic neuritis in concomitant with pituitary macroadenoma following COVID-19 infection represents a dilemma of whether the visual symptoms are attributed to the tumor or COVID-19 infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Highlights<\/jats:title>\n          <\/jats:sec>","DOI":"10.1016\/j.ijso.2021.100390","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T06:45:43Z","timestamp":1629873943000},"page":"100390","source":"Crossref","is-referenced-by-count":5,"title":["Optic neuritis concomitant with pituitary macroadenoma in a patient with active COVID-19 infection: A case report"],"prefix":"10.1097","volume":"35","author":[{"given":"Mohammed Maan","family":"Al-Salihi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshiur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Sabah","family":"Al-Jebur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan David","family":"Lozada-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphia","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Rafael","family":"Moscote-Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"3","key":"R3-19-20240223","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4103\/ijo.IJO_297_21","article-title":"COVID-19 and eye: a review of ophthalmic manifestations of COVID-19","volume":"69","author":"Sen","year":"2021","journal-title":"Indian J Ophthalmol"},{"issue":"3","key":"R9-19-20240223","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/WNO.0000000000001049","article-title":"Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis and myelitis in COVID-19","volume":"40","author":"Zhou","year":"2020","journal-title":"J Neuroophthalmol"},{"issue":"8","key":"R11-19-20240223","doi-asserted-by":"crossref","first-page":"e1060","DOI":"10.1212\/WNL.0000000000009937","article-title":"Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry","volume":"95","author":"Romero-S\u00e1nchez","year":"2020","journal-title":"Neurology"},{"issue":"3","key":"R12-19-20240223","first-page":"117","article-title":"Pituitary apoplexy presented with optic neuritis","volume":"12","author":"Moghadasi","year":"2013","journal-title":"Iran. J. Neurol."},{"issue":"2","key":"R13-19-20240223","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/0885066607312992","article-title":"Pituitary tumor apoplexy: a review","volume":"23","author":"Nawar","year":"2008","journal-title":"J Intensive Care Med"},{"issue":"4","key":"R15-19-20240223","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4103\/ijo.IJO_3321_20","article-title":"Neuro-ophthalmic presentation of COVID-19 disease: a case report","volume":"69","author":"Katti","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R16-19-20240223","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE 2020 guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int J Surg"}],"container-title":["International Journal of Surgery Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405857221000814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405857221000814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijso.2021.100390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T15:34:06Z","timestamp":1708702446000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijso.2021.100390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":7,"URL":"https:\/\/doi.org\/10.1016\/j.ijso.2021.100390","relation":{},"ISSN":["2405-8572"],"issn-type":[{"value":"2405-8572","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}