{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:02:06Z","timestamp":1791810126816,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":731,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI068642"],"award-info":[{"award-number":["U01 AI068642"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI074844"],"award-info":[{"award-number":["R21 AI074844"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI090959"],"award-info":[{"award-number":["U19 AI090959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Surgery"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ijsu.2015.06.066","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T23:15:37Z","timestamp":1437088537000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"PB","title":["The need for xenotransplantation as a source of organs and cells for clinical transplantation"],"prefix":"10.1097","volume":"23","author":[{"given":"Burcin","family":"Ekser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.C.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Joseph","family":"Tector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.ijsu.2015.06.066_bib1","unstructured":"UNOS - United Network for Organ Sharing (UNOS). http:\/\/www.unos.org. Last accessed on February 10th, 2015."},{"key":"10.1016\/j.ijsu.2015.06.066_bib2","unstructured":"OPTN \u2013 Organ Procurement and Transplantation Network. http:\/\/optn.transplant.hrsa.gov. Last accessed on February 10th, 2015."},{"key":"10.1016\/j.ijsu.2015.06.066_bib3","unstructured":"NIH Archives. http:\/\/history.nih.gov\/research\/downloads\/PL98-507.pdf. Last accessed in February 10, 2015."},{"key":"10.1016\/j.ijsu.2015.06.066_bib4","series-title":"United States Renal Data System","author":"USRDS","year":"2013"},{"key":"10.1016\/j.ijsu.2015.06.066_bib5","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/S0140-6736(14)60835-7","article-title":"A\u00a0needed convention against trafficking in human organs","volume":"383","author":"L\u00f3pez-Fraga","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ijsu.2015.06.066_bib6","unstructured":"Newsletter Transplant. International figures on donation and transplantation in 2012. https:\/\/www.edqm.eu\/site\/newsletter_transplant_vol_18_no_1_september_2013pdf-en-31256-2.html. Last accessed in February 10, 2015."},{"key":"10.1016\/j.ijsu.2015.06.066_bib7","unstructured":"Global Observatory on Organ Donation and Transplantation. Data reports, 2012 data. http:\/\/www.transplant-observatory.org\/Pages\/Data-Reports.aspx. Last accessed on February 10, 2015."},{"key":"10.1016\/j.ijsu.2015.06.066_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.7182\/pit2014730","article-title":"Organ donation in China: current status, challenges, and future development","volume":"24","author":"Sui","year":"2014","journal-title":"Prog. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib9","doi-asserted-by":"crossref","first-page":"826","DOI":"10.2471\/BLT.14.137653","article-title":"The global diffusion of organ transplantation: trends, drivers and policy implications","volume":"92","author":"White","year":"2014","journal-title":"Bull. World. Health. Organ"},{"key":"10.1016\/j.ijsu.2015.06.066_bib10","unstructured":"WHO Diabetes Programme. http:\/\/www.who.int\/diabetes\/en\/. Last accessed on February 7, 2015."},{"key":"10.1016\/j.ijsu.2015.06.066_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/ICO.0b013e3181f237ef","article-title":"Xenotransplantation\u2013the future of corneal transplantation?","volume":"30","author":"Hara","year":"2011","journal-title":"Cornea"},{"key":"10.1016\/j.ijsu.2015.06.066_bib12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1600-6143.2008.02200.x","article-title":"Organ trafficking and transplant tourism: a commentary on the global realities","volume":"8","author":"Budiani-Saberi","year":"2008","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib13","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1111\/ajt.12871","article-title":"Organ procurement from executed prisoners in China","volume":"14","author":"Sharif","year":"2014","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev.med.53.082901.103900","article-title":"Will the pig solve the transplantation backlog?","volume":"53","author":"Cooper","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ijsu.2015.06.066_bib15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(11)61091-X","article-title":"Clinical xenotransplantation: the next medical revolution?","volume":"379","author":"Ekser","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ijsu.2015.06.066_bib16","doi-asserted-by":"crossref","unstructured":"D.K. Cooper, Y. Ye, L.J. Rolf, et\u00a0al. Xenotransplantation. Chapter 30. Heideiberg: 1991. The pig as potential organ donor for man; pp. 481\u2013500.","DOI":"10.1007\/978-3-642-97323-9_30"},{"key":"10.1016\/j.ijsu.2015.06.066_bib17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1399-3089.2006.00346.x","article-title":"Selected physiological compatibilities and incompatibilities between human and porcine systems","volume":"13","author":"Ibrahim","year":"2006","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib18","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jtcvs.2014.06.002","article-title":"Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation","volume":"148","author":"Mohiuddin","year":"2014","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ijsu.2015.06.066_bib19","first-page":"356","article-title":"Early cardiac function and gene expression after orthotopic cardiac xenotransplantation","volume":"16","author":"McGregor","year":"2009","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib20","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1046\/j.1523-1755.2001.00973.x","article-title":"Physiological aspects of pig-to-primate renal xenotransplantation","volume":"60","author":"Soin","year":"2001","journal-title":"Kidney. Int."},{"key":"10.1016\/j.ijsu.2015.06.066_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nm1172","article-title":"Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue","volume":"11","author":"Yamada","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijsu.2015.06.066_bib22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1681\/ASN.2013040363","article-title":"Rituximab treatment prevents the early development of proteinuria following pig-to-baboon xeno-kidney transplantation","volume":"25","author":"Tasaki","year":"2014","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.ijsu.2015.06.066_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ki.2013.381","article-title":"Kidney xenotransplantation","volume":"85","author":"Cowan","year":"2014","journal-title":"Kidney. Int."},{"key":"10.1016\/j.ijsu.2015.06.066_bib24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/bjs.4053","article-title":"Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy","volume":"90","author":"Court","year":"2003","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.ijsu.2015.06.066_bib25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/TP.0b013e3181e98d51","article-title":"Hepatic function after genetically engineered pig liver xenotransplantation in baboons","volume":"90","author":"Ekser","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/xen.12007","article-title":"Comparison of hematologic, biochemical, and coagulation parameters in \u03b11,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species","volume":"19","author":"Ekser","year":"2012","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-6143.2009.02945.x","article-title":"Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance","volume":"10","author":"Ekser","year":"2010","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1399-3089.2012.00717.x","article-title":"Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons","volume":"19","author":"Kim","year":"2012","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-6143.2006.01603.x","article-title":"Prolonged function of macrophage, von Willibrand factor-deficient porcine pulmonary xenografts","volume":"7","author":"Cantu","year":"2007","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib30","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.2337\/db12-0033","article-title":"Clinical islet xenotransplantation: how close are we?","volume":"61","author":"van der Windt","year":"2012","journal-title":"Diabetes"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.ijsu.2015.06.066_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00007890-201007272-00090","article-title":"Long-term clinical recovery in parkinsonian monkey recipients of CTLA4-Ig transgenic porcine neural precursors","volume":"90","author":"Badin","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib32","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/TP.0b013e3181ba0555","article-title":"Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?","volume":"88","author":"Ekser","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.066_bib33","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.healun.2010.03.017","article-title":"Pig heart xenotransplantation as a bridge to allotransplantation","volume":"29","author":"Cooper","year":"2010","journal-title":"J.\u00a0Heart. Lung. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijsu.2010.11.002","article-title":"The immense potential of xenotransplantation in surgery","volume":"9","author":"Cooper","year":"2011","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.ijsu.2015.06.066_bib35","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI118929","article-title":"Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression","volume":"98","author":"Sun","year":"1996","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.ijsu.2015.06.066_bib36","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1111\/j.1600-6143.2009.02850.x","article-title":"Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets","volume":"9","author":"van der Windt","year":"2009","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/ajt.13057","article-title":"Blockade of CD40\u2013CD154 costimulatory pathway promotes long-term survival of full-thickness porcine corneal grafts in nonhuman primates: clinically applicable xenocorneal transplantation","volume":"15","author":"Choi","year":"2015","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.066_bib38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1053\/j.gastro.2006.10.013","article-title":"Prolonged survival of porcine hepatocytes in cynomolgus monkeys","volume":"132","author":"Nagata","year":"2007","journal-title":"Gastroenterology"}],"container-title":["International Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919115003490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919115003490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T16:01:10Z","timestamp":1677081670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1743919115003490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":38,"alternative-id":["S1743919115003490"],"URL":"https:\/\/doi.org\/10.1016\/j.ijsu.2015.06.066","relation":{},"ISSN":["1743-9191"],"issn-type":[{"value":"1743-9191","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The need for xenotransplantation as a source of organs and cells for clinical transplantation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijsu.2015.06.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}