{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:06Z","timestamp":1792788726657,"version":"4.5.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":731,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["U01 AI068642"],"award-info":[{"award-number":["U01 AI068642"]}]},{"name":"NIH","award":["R21 AI074844"],"award-info":[{"award-number":["R21 AI074844"]}]},{"name":"NIH","award":["U19 AI090959"],"award-info":[{"award-number":["U19 AI090959"]}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Surgery"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ijsu.2015.06.068","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T01:48:39Z","timestamp":1436233719000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"special_numbering":"PB","title":["Immunobiological barriers to xenotransplantation"],"prefix":"10.1097","volume":"23","author":[{"given":"David K.C.","family":"Cooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcin","family":"Ekser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Joseph","family":"Tector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.ijsu.2015.06.068_bib1","first-page":"411","article-title":"Hyperacute rejection in a discordant (pig to baboon) cardiac xenograft model","volume":"5","author":"Lexer","year":"1986","journal-title":"J.\u00a0Heart Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib2","first-page":"238","article-title":"Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon","volume":"7","author":"Cooper","year":"1988","journal-title":"J.\u00a0Heart Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib3","series-title":"Xenograft 25","first-page":"259","article-title":"Plasmapheresis and splenectomy in experimental renal xenotransplantation","author":"Alexandre","year":"1989"},{"key":"10.1016\/j.ijsu.2015.06.068_bib4","first-page":"223","article-title":"Histopathology of hyperacute rejection of the heart: experimental and clinical observations in allografts and xenografts","volume":"10","author":"Rose","year":"1991","journal-title":"J.\u00a0Heart Lung Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1034\/j.1399-3089.2000.00042.x","article-title":"Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection","volume":"7","author":"Rose","year":"2000","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib6","first-page":"229","article-title":"Anti-Gal, alpha-Gal epitopes, and xenotransplantation","volume":"32","author":"Kobayashi","year":"1999","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.ijsu.2015.06.068_bib7","first-page":"1","article-title":"Evolution of alpha 1,3galactosyltransferase and of the alpha-Gal epitope","volume":"32","author":"Galili","year":"1999","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.ijsu.2015.06.068_bib8","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1432-2277.2007.00546.x","article-title":"Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants","volume":"20","author":"Rood","year":"2007","journal-title":"Transpl. Int."},{"key":"10.1016\/j.ijsu.2015.06.068_bib9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/TP.0b013e3182481168","article-title":"T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons","volume":"93","author":"Dons","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib10","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1128\/IAI.56.7.1730-1737.1988","article-title":"Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora","volume":"56","author":"Galili","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijsu.2015.06.068_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1399-3089.2006.00324.x","article-title":"ABO-incompatible allotransplantation as a basis for clinical xenotransplantation","volume":"13","author":"Stussi","year":"2006","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib12","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1097\/00007890-199611270-00001","article-title":"In\u00a0vivo immunoadsorption of antipig antibodies in baboons using a specific Gal(alpha)1-3Gal column","volume":"62","author":"Taniguchi","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00007890-199408000-00014","article-title":"Evidence that intravenously administered alpha-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts","volume":"58","author":"Ye","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00007890-199802150-00009","article-title":"Intravenous infusion of Galalpha1-3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts","volume":"65","author":"Simon","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib15","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/00007890-199403270-00035","article-title":"The synergistic effect of combined antibody and complement depletion on discordant cardiac xenograft survival in nonhuman primates","volume":"57","author":"Leventhal","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1097\/00007890-199711150-00005","article-title":"Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy","volume":"64","author":"Kobayashi","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib17","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/00007890-199109000-00029","article-title":"Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection","volume":"52","author":"Dalmasso","year":"1991","journal-title":"Transplantation"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ijsu.2015.06.068_bib18","doi-asserted-by":"crossref","first-page":"S648","DOI":"10.1111\/tri.1992.5.s1.648","article-title":"Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement","volume":"5","author":"White","year":"1992","journal-title":"Transpl. Int."},{"key":"10.1016\/j.ijsu.2015.06.068_bib19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/00007890-199809150-00001","article-title":"Discordant organ xenotransplantation in primates: world experience and current status","volume":"66","author":"Lambrigts","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib20","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0140-6736(93)91791-J","article-title":"Genetically engineered pigs","volume":"342","author":"Cooper","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ijsu.2015.06.068_bib21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1078942","article-title":"Production of alpha 1,3-galactosyltransferase-deficient pigs","volume":"299","author":"Phelps","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ijsu.2015.06.068_bib22","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1073\/pnas.0307819101","article-title":"Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations","volume":"101","author":"Kolber-Simonds","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijsu.2015.06.068_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nm1171","article-title":"Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience","volume":"11","author":"Kuwaki","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijsu.2015.06.068_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nm1172","article-title":"Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue","volume":"11","author":"Yamada","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijsu.2015.06.068_bib25","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/01.TP.0000131167.21930.B8","article-title":"Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity","volume":"77","author":"Gollackner","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib26","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1432-2277.2008.00736.x","article-title":"In\u00a0vitro investigation of pig cells for resistance to human antibody-mediated rejection","volume":"21","author":"Hara","year":"2008","journal-title":"Transpl. Int."},{"key":"10.1016\/j.ijsu.2015.06.068_bib27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/TP.0b013e3182472850","article-title":"Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts","volume":"93","author":"McGregor","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib28","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1097\/00007890-200006150-00013","article-title":"High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response","volume":"69","author":"Buhler","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib29","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1034\/j.1399-3089.2003.02014.x","article-title":"Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts","volume":"10","author":"Cozzi","year":"2003","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jtcvs.2005.04.017","article-title":"Cardiac xenotransplantation: recent preclinical progress with 3-month median survival","volume":"130","author":"McGregor","year":"2005","journal-title":"J.\u00a0Thorac. Cardiovasc Surg."},{"key":"10.1016\/j.ijsu.2015.06.068_bib31","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/TP.0b013e31829bbcb2","article-title":"New concepts of immune modulation in xenotransplantation","volume":"96","author":"Satyananda","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1399-3089.2009.00533.x","article-title":"Production and characterization of transgenic pigs expressing porcine CTLA4-Ig","volume":"16","author":"Phelps","year":"2009","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/imm.12107","article-title":"Human dominant-negative class II transactivator transgenic pigs \u2013 effect on the human anti-pig T-cell immune response and immune status","volume":"140","author":"Hara","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.ijsu.2015.06.068_bib34","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.4049\/jimmunol.1402059","article-title":"Creating class I MHC-null pigs using guide RNA and the Cas9 endonuclease","volume":"193","author":"Reyes","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ijsu.2015.06.068_bib35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1034\/j.1399-3089.2000.00067.x","article-title":"Disordered regulation of coagulation and platelet activation in xenotransplantation","volume":"7","author":"Robson","year":"2000","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/MOT.0b013e3283446c65","article-title":"Controlling coagulation dysregulation in xenotransplantation","volume":"16","author":"Cowan","year":"2011","journal-title":"Curr. Opin. Organ Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib37","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1097\/00007890-200011150-00010","article-title":"Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates","volume":"70","author":"Buhler","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib38","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1399-3089.2004.00155.x","article-title":"Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons","volume":"11","author":"Houser","year":"2004","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib39","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1600-6143.2010.03147.x","article-title":"Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation","volume":"10","author":"Lin","year":"2010","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib40","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1600-6143.2009.02602.x","article-title":"Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation","volume":"9","author":"Knosalla","year":"2009","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib41","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1097\/01.tp.0000251387.40499.0f","article-title":"Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival","volume":"82","author":"Byrne","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib42","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jtcvs.2014.06.002","article-title":"Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation","volume":"148","author":"Mohiuddin","year":"2014","journal-title":"J.\u00a0Thorac. Cardiovasc Surg."},{"key":"10.1016\/j.ijsu.2015.06.068_bib43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/xen.12133","article-title":"Systemic inflammation in xenograft recipients precedes activation of coagulation","volume":"22","author":"Ezzelarab","year":"2015","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib44","unstructured":"H. Iwase, B. Ekser, H. Zhou, H. Liu, V. Satyananda, R. Humar, et\u00a0al., Further Evidence for a Sustained Systemic Inflammatory Response in Xenograft Recipients (SIXR), Submitted for publication."},{"key":"10.1016\/j.ijsu.2015.06.068_bib45","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1600-6143.2004.00353.x","article-title":"Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen","volume":"4","author":"Kuwaki","year":"2004","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib46","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1586\/eci.12.56","article-title":"Immunobiology of liver xenotransplantation","volume":"8","author":"Ekser","year":"2012","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.ijsu.2015.06.068_bib47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/xen.12149","article-title":"Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex\u00a0vivo perfusion with human blood","volume":"22","author":"Harris","year":"2015","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib48","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/xen.12127","article-title":"Progress in pig-to-nonhuman primate transplantation models (1998\u20132013): a comprehensive review of the literature","volume":"21","author":"Cooper","year":"2014","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3089.2011.00622.x","article-title":"Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk","volume":"18","author":"Padler-Karavani","year":"2011","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib50","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/xen.12124","article-title":"Cloning and expression of porcine beta1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen","volume":"21","author":"Byrne","year":"2014","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/xen.12019","article-title":"Double knockout pigs deficient in N-glycolylneuraminic acid and galactose alpha-1,3-galactose reduce the humoral barrier to xenotransplantation","volume":"20","author":"Lutz","year":"2013","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib52","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.2337\/db12-0033","article-title":"Clinical islet xenotransplantation: how close are we?","volume":"61","author":"van der Windt","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.ijsu.2015.06.068_bib53","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1111\/ajt.12868","article-title":"Pig-to-monkey islet xenotransplantation using multi-transgenic pigs","volume":"14","author":"Bottino","year":"2014","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib54","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1111\/j.1600-6143.2009.02850.x","article-title":"Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets","volume":"9","author":"van der Windt","year":"2009","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib55","article-title":"Long-term control of diabetes in imunosuppressed nonhuman primates (NHP) by the transplantation of adult porcine islets","author":"Shin","year":"1915","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib56","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nm1375","article-title":"Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways","volume":"12","author":"Cardona","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijsu.2015.06.068_bib57","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1111\/j.1600-6143.2011.03720.x","article-title":"Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function","volume":"11","author":"Thompson","year":"2011","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.ijsu.2015.06.068_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.TP.0000146504.73727.13","article-title":"Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress","volume":"79","author":"Tseng","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.ijsu.2015.06.068_bib59","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/ajt.13070","article-title":"High incidence of xenogenic bone marrow engraftment in pig-to-baboon intra-bone bone marrow transplantation","volume":"15","author":"Tasaki","year":"2015","journal-title":"Am. J. Transpl."}],"container-title":["International Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919115003519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919115003519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T11:01:14Z","timestamp":1677063674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1743919115003519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":59,"alternative-id":["S1743919115003519"],"URL":"https:\/\/doi.org\/10.1016\/j.ijsu.2015.06.068","relation":{},"ISSN":["1743-9191"],"issn-type":[{"value":"1743-9191","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunobiological barriers to xenotransplantation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijsu.2015.06.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}