{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:32:50Z","timestamp":1788978770942,"version":"build-2803163510"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Surgery"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ijsu.2017.02.008","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T13:45:36Z","timestamp":1487079936000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis"],"prefix":"10.1097","volume":"40","author":[{"given":"Xiaoshuang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"10.1016\/j.ijsu.2017.02.008_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"2","key":"10.1016\/j.ijsu.2017.02.008_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jama.293.2.217","article-title":"Preventing foot ulcers in patients with diabetes","volume":"293","author":"Singh","year":"2005","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2337\/diacare.22.3.382","article-title":"Incidence, outcomes, and cost of foot ulcers in patients with diabetes","volume":"22","author":"Ramsey","year":"1999","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib4","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2337\/dc13-2176","article-title":"Burden of diabetic foot ulcers for medicare and private insurers","volume":"37","author":"Rice","year":"2014","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.ijsu.2017.02.008_bib5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.7547\/0990406","article-title":"Quality of life in people with their first diabetic foot ulcer: a prospective cohort study","volume":"99","author":"Winkley","year":"2009","journal-title":"J.\u00a0Am. Podiatric Med. Assoc."},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s40257-014-0081-9","article-title":"Diabetic foot ulcer: an evidence-based treatment update","volume":"15","author":"Braun","year":"2014","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.ijsu.2017.02.008_bib7","first-page":"1","article-title":"A\u00a0prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic foot ulcers","author":"Zelen","year":"2016","journal-title":"Int. Wound J."},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1742-481X.2009.00585.x","article-title":"Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study","volume":"6","author":"Reyzelman","year":"2009","journal-title":"Int. Wound J."},{"issue":"5","key":"10.1016\/j.ijsu.2017.02.008_bib9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.2337\/diacare.22.5.692","article-title":"Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis","volume":"22","author":"Margolis","year":"1999","journal-title":"Diabetes Care."},{"issue":"6","key":"10.1016\/j.ijsu.2017.02.008_bib10","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/iwj.12395","volume":"12","author":"Zelen","year":"2015","journal-title":"Int. Wound J."},{"issue":"5","key":"10.1016\/j.ijsu.2017.02.008_bib11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/SAP.0b013e31827a2d23","article-title":"The evidence base for the acellular dermal matrix AlloDerm: a systematic review","volume":"70","author":"Jansen","year":"2013","journal-title":"Ann. Plastic Surg."},{"issue":"6","key":"10.1016\/j.ijsu.2017.02.008_bib12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/iwj.12185","article-title":"Human acellular dermal wound matrix: evidence and experience","volume":"12","author":"Kirsner","year":"2015","journal-title":"Int. Wound J."},{"issue":"4","key":"10.1016\/j.ijsu.2017.02.008_bib13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.suc.2014.05.013","article-title":"Clinical applications of skin substitutes","volume":"94","author":"Nyame","year":"2014","journal-title":"Surg. Clin. North Am."},{"issue":"1","key":"10.1016\/j.ijsu.2017.02.008_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jbm.820140108","article-title":"Design of an artificial skin. I. Basic design principles","volume":"14","author":"Yannas","year":"1980","journal-title":"J.\u00a0Biomed. Mater. Res."},{"issue":"7 Suppl","key":"10.1016\/j.ijsu.2017.02.008_bib15","doi-asserted-by":"crossref","first-page":"160S","DOI":"10.1097\/01.prs.0000222609.40461.68","article-title":"Reconstructive surgery with Integra dermal regeneration template: histologic study, clinical evaluation, and current practice","volume":"117","author":"Moiemen","year":"2006","journal-title":"Plastic Reconstr. Surg."},{"issue":"1","key":"10.1016\/j.ijsu.2017.02.008_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00004630-199001000-00003","article-title":"Histologic study of artificial skin used in the treatment of full-thickness thermal injury","volume":"11","author":"Stern","year":"1990","journal-title":"J.\u00a0Burn Care Rehab."},{"key":"10.1016\/j.ijsu.2017.02.008_bib17","first-page":"891","volume":"vol. 23(6)","author":"Driver","year":"2015"},{"issue":"1","key":"10.1016\/j.ijsu.2017.02.008_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00004630-200301000-00009","article-title":"Multicenter postapproval clinical trial of Integra dermal regeneration template for burn treatment","volume":"24","author":"Heimbach","year":"2003","journal-title":"J.\u00a0Burn Care Rehab."},{"issue":"7","key":"10.1016\/j.ijsu.2017.02.008_bib19","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.ijsu.2017.02.008_bib20","series-title":"Cochrane handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins JPT","year":"2011"},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1053\/jhep.2002.31354","article-title":"Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis","volume":"35","author":"Banares","year":"2002","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ijsu.2017.02.008_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1742-4801.2005.00099.x","article-title":"Outcomes of allogenic acellular matrix therapy in treatment of diabetic foot wounds: an initial experience","volume":"2","author":"Martin","year":"2005","journal-title":"Int. Wound J."},{"issue":"4","key":"10.1016\/j.ijsu.2017.02.008_bib23","article-title":"Human acellular dermal wound matrix for complex diabetic wounds","volume":"25","author":"Rupert","year":"2016","journal-title":"J.\u00a0Wound care."},{"issue":"4","key":"10.1016\/j.ijsu.2017.02.008_bib24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.7547\/1030274","article-title":"Ease of use, safety, and efficacy of integra bilayer wound matrix in the treatment of diabetic foot ulcers in an outpatient clinical setting: a prospective pilot study","volume":"103","author":"Yao","year":"2013","journal-title":"J.\u00a0Am. Podiatric Med. Assoc."},{"issue":"8","key":"10.1016\/j.ijsu.2017.02.008_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/01.ASW.0000323532.98003.26","article-title":"A\u00a0multicenter study involving the use of a human acellular dermal regenerative tissue matrix for the treatment of diabetic lower extremity wounds","volume":"21","author":"Winters","year":"2008","journal-title":"Adv. Skin Wound Care"},{"issue":"6","key":"10.1016\/j.ijsu.2017.02.008_bib26","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jamcollsurg.2016.02.023","article-title":"Composite skin grafting with human acellular dermal matrix scaffold for treatment of diabetic foot ulcers: a randomized controlled trial","volume":"222","author":"Hu","year":"2016","journal-title":"J.\u00a0Am. Coll. Surg."},{"issue":"1","key":"10.1016\/j.ijsu.2017.02.008_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7547\/1000073","article-title":"Confirmatory data from EU study supports Apligraf for the treatment of neuropathic diabetic foot ulcers","volume":"100","author":"Steinberg","year":"2010","journal-title":"J.\u00a0Am. Podiatric Med. Assoc."},{"key":"10.1016\/j.ijsu.2017.02.008_bib28","first-page":"e10","article-title":"Healing rates in a multicenter assessment of a sterile, room temperature, acellular dermal matrix versus conventional care wound management and an active comparator in the treatment of full-thickness diabetic foot ulcers","volume":"16","author":"Walters","year":"2016","journal-title":"Eplasty"},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib29","first-page":"181","article-title":"The use an acellular dermal regenerative tissue matrix in the treatment of lower extremity wounds: a prospective 16-week pilot study","author":"SA","year":"2006","journal-title":"Int. Wound J."},{"key":"10.1016\/j.ijsu.2017.02.008_bib30","doi-asserted-by":"crossref","first-page":"s145","DOI":"10.3928\/0147-7447-20040102-14","article-title":"Effective management of major lower extremity wounds using an acellular regenerative tissue matrix: a pilot study","volume":"27","author":"RC BSBSL","year":"2004","journal-title":"Orthopedics"},{"issue":"5","key":"10.1016\/j.ijsu.2017.02.008_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00403-011-1131-2","article-title":"Dermal substitute-assisted healing: enhancing stem cell therapy with novel biomaterial design","volume":"303","author":"Hodgkinson","year":"2011","journal-title":"Archives Dermatol. Res."},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1742-481X.2006.00209.x","article-title":"The use of an acellular dermal regenerative tissue matrix in the treatment of lower extremity wounds: a prospective 16-week pilot study","volume":"3","author":"Brigido","year":"2006","journal-title":"Int. Wound J."},{"issue":"1 Suppl","key":"10.1016\/j.ijsu.2017.02.008_bib33","doi-asserted-by":"crossref","first-page":"s145","DOI":"10.3928\/0147-7447-20040102-14","article-title":"Effective management of major lower extremity wounds using an acellular regenerative tissue matrix: a pilot study","volume":"27","author":"Brigido","year":"2004","journal-title":"Orthopedics"},{"issue":"3","key":"10.1016\/j.ijsu.2017.02.008_bib34","article-title":"Human acellular dermal wound matrix for treatment of DFU: literature review and analysis","volume":"24","author":"Reyzelman","year":"2015","journal-title":"J.\u00a0Wound Care"},{"key":"10.1016\/j.ijsu.2017.02.008_bib35","first-page":"CD011255","article-title":"Skin grafting and tissue replacement for treating foot ulcers in people with diabetes","volume":"2","author":"Santema","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.ijsu.2017.02.008_bib36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/iwj.12329","article-title":"The efficacy and safety of Grafix((R)) for the treatment of chronic diabetic foot ulcers: results of a multi-centre, controlled, randomised, blinded, clinical trial","volume":"11","author":"Lavery","year":"2014","journal-title":"Int. Wound J."},{"issue":"2","key":"10.1016\/j.ijsu.2017.02.008_bib37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/iwj.12566","article-title":"Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost","volume":"13","author":"Zelen","year":"2016","journal-title":"Int. Wound J."},{"issue":"2","key":"10.1016\/j.ijsu.2017.02.008_bib38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2337\/diacare.24.2.290","article-title":"Apligraf Diabetic Foot Ulcer S. Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial","volume":"24","author":"Veves","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijsu.2017.02.008_bib39","first-page":"134","volume":"vol. 19(2)","author":"Schultz","year":"2011"},{"issue":"6","key":"10.1016\/j.ijsu.2017.02.008_bib40","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2337\/diacare.26.6.1701","article-title":"Dermagraft Diabetic Foot Ulcer Study G. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial","volume":"26","author":"Marston","year":"2003","journal-title":"Diabetes Care"}],"container-title":["International Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919117301309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919117301309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T16:04:29Z","timestamp":1677081869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1743919117301309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":40,"alternative-id":["S1743919117301309"],"URL":"https:\/\/doi.org\/10.1016\/j.ijsu.2017.02.008","relation":{},"ISSN":["1743-9191"],"issn-type":[{"value":"1743-9191","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijsu.2017.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}