{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:29:42Z","timestamp":1785382182257,"version":"3.55.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Surgery"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.ijsu.2017.12.022","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T08:00:29Z","timestamp":1514275229000},"page":"60-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Mastectomy for risk reduction or symmetry in women without high risk gene mutation: A review"],"prefix":"10.1097","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-631X","authenticated-orcid":false,"given":"R.","family":"Kenny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.ijsu.2017.12.022_bib1","series-title":"Association of Breast Surgery UK Summary Statement: Contralateral Mastectomy for Unilateral Breast Cancer","year":"2017"},{"issue":"10","key":"10.1016\/j.ijsu.2017.12.022_bib2","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1245\/s10434-016-5443-5","article-title":"Contralateral prophylactic mastectomy consensus statement from the American Society of Breast Surgeons: the data on CPM outcomes and risks","volume":"23","author":"Boughey","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.ijsu.2017.12.022_bib3","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1200\/JCO.2007.12.3141","article-title":"Increasing use of contralateral prophylactic mastectomy for breast cancer patients: a trend toward more aggressive surgical treatment","volume":"25","author":"Tuttle","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"Suppl. 3","key":"10.1016\/j.ijsu.2017.12.022_bib4","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1016\/S0960-9776(09)70282-6","article-title":"Should the use of contralateral prophylactic mastectomy be increasing as it is?","volume":"18","author":"Wood","year":"2009","journal-title":"Breast"},{"key":"10.1016\/j.ijsu.2017.12.022_bib5","article-title":"Growing use of contralateral prophylactic mastectomy despite no improvement in long term survival for invasive breast cancer","author":"Wong","year":"2016","journal-title":"Ann. Surg."},{"issue":"3","key":"10.1016\/j.ijsu.2017.12.022_bib6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/PRS.0000000000001044","article-title":"Defining the relationship between patient decision to undergo breast reconstruction and contralateral prophylactic mastectomy","volume":"135","author":"Agarwal","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"issue":"6","key":"10.1016\/j.ijsu.2017.12.022_bib7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.surge.2014.02.005","article-title":"Increasing trend of contralateral prophylactic mastectomy: what are the factors behind this phenomenom?","volume":"12","author":"Soran","year":"2014","journal-title":"Surgeon"},{"key":"10.1016\/j.ijsu.2017.12.022_bib8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1245\/s10434-009-0362-3","article-title":"Diagnostic breast magnetic resonance imaging and contralateral prophylactic mastectomy","volume":"16","author":"Sorbero","year":"2009","journal-title":"Ann. Surg Oncol."},{"issue":"17 Suppl","key":"10.1016\/j.ijsu.2017.12.022_bib9","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1245\/s10434-010-1259-x","article-title":"Increase in contralateral prophylactic mastectomy: echoes of a bygone era? Surgical trends for unilateral breast cancer","volume":"3","author":"Stucky","year":"2010","journal-title":"Ann. Surg Oncol."},{"issue":"Suppl 3","key":"10.1016\/j.ijsu.2017.12.022_bib10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0960-9776(11)70306-X","article-title":"Prophylactic mastectomy of the contralateral breast","volume":"20","author":"Morrow","year":"2011","journal-title":"Breast"},{"key":"10.1016\/j.ijsu.2017.12.022_bib11","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2013.5689","article-title":"Social and clinical determinants of contralateral prophylactic mastectomy","volume":"149","author":"Hawley","year":"2014","journal-title":"JAMA Surg"},{"key":"10.1016\/j.ijsu.2017.12.022_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003179","article-title":"Trends in the use of bilateral mastectomy in England from 2002 to 2011: retrospective analysis of hospital episode statistics","volume":"3","author":"Neuburger","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.ijsu.2017.12.022_bib13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ejso.2011.12.014","article-title":"Increasing rates of contralateral prophylactic mastectomy\u2014a trend made in USA?","volume":"38","author":"Guth","year":"2012","journal-title":"Eur. J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.ijsu.2017.12.022_bib14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1586\/14737140.2014.883284","article-title":"Contralateral prophylactic mastectomy: are we overtreating patients","volume":"14","author":"Burke","year":"2014","journal-title":"Expet Rev. Anticancer Ther."},{"key":"10.1016\/j.ijsu.2017.12.022_bib15","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1245\/s10434-010-1434-0","article-title":"Mastectomy and contralateral prophylactic mastectomy rates: an institutional review","volume":"18","author":"Damle","year":"2011","journal-title":"Ann. Surg Oncol."},{"issue":"11","key":"10.1016\/j.ijsu.2017.12.022_bib17","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1200\/JCO.1993.11.11.2090","article-title":"Factors influencing prognosis in node-negative breast carcinoma: analysis of 767 T1N0M0\/T2N0M0 patients with long-term follow-up","volume":"11","author":"Rosen","year":"1993","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.ijsu.2017.12.022_bib18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S1470-2045(10)70257-6","article-title":"Effect of anastrozole and tamoxifen as adjuvant treatment for early- stage breast cancer: 10-year analysis of the ATAC trial","volume":"11","author":"Cuzick","year":"2010","journal-title":"Lancet Oncol."},{"issue":"11","key":"10.1016\/j.ijsu.2017.12.022_bib19","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1245\/s10434-011-1914-x","article-title":"Perceptions of contralateral breast cancer: an overestimation of risk","volume":"18","author":"Abbott","year":"2011","journal-title":"Ann. Surg Oncol."},{"issue":"11","key":"10.1016\/j.ijsu.2017.12.022_bib20","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1245\/s10434-011-1917-7","article-title":"Contralateral prophylactic mastectomy: long-term consistency of satisfaction and adverse effects and the significance of informed decision-making, quality of life, and personality traits","volume":"18","author":"Frost","year":"2011","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.ijsu.2017.12.022_bib21","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g226","article-title":"Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis","volume":"348","author":"Metcalfe","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.ijsu.2017.12.022_bib22","volume":"vol 29","author":"BRCA1 and BRCA2: Cancer Risk and Genetic Testing","year":"2009"},{"issue":"3","key":"10.1016\/j.ijsu.2017.12.022_bib23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am. J. Hum. Genet."},{"issue":"9099","key":"10.1016\/j.ijsu.2017.12.022_bib24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0140-6736(97)07065-7","article-title":"Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1","volume":"351","author":"Verhoog","year":"1998","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ijsu.2017.12.022_bib25","article-title":"Contralateral prophylactic mastectomy","volume":"15","author":"Tanday","year":"2014","journal-title":"Incremental Survival Lancet Oncol"},{"key":"10.1016\/j.ijsu.2017.12.022_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrclinonc.2014.116","article-title":"Breast cancer: why do women opt for contralateral prophylactic mastectomy?","volume":"11","author":"Goldhirsch","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ijsu.2017.12.022_bib27","first-page":"355","article-title":"Do celebrity endorsements matter? Observational study of BRCA gene testing and mastectomy rates after Angelina Jolie's New York Times editorial","author":"Desai","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.ijsu.2017.12.022_bib28","volume":"vol 25","author":"NICE guideline CG164","year":"2013"},{"issue":"4","key":"10.1016\/j.ijsu.2017.12.022_bib29","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1200\/JCO.2012.43.2013","article-title":"Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's environmental cancer and radiation Epidemiology study","volume":"31","author":"Reiner","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ijsu.2017.12.022_bib30","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1158\/1940-6207.CAPR-09-0130","article-title":"Factors affecting the decision of breast cancer patients to undergo contralateral prophylactic mastectomy","volume":"3","author":"Yi","year":"2010","journal-title":"Canc. Prev. Res."},{"issue":"4","key":"10.1016\/j.ijsu.2017.12.022_bib31","first-page":"3748","article-title":"Predictors for contralateral prophylactic mastectomy in breast cancer patients","volume":"8","author":"Fu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"8","key":"10.1016\/j.ijsu.2017.12.022_bib32","first-page":"106","article-title":"Survival outcomes after contralateral prophylactic mastectomy: a decision analysis","author":"Portschy","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijsu.2017.12.022_bib33","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1245\/s10434-009-0641-z","article-title":"Patient and surgeon characteristics associated with increased use of contralateral prophylactic mastectomy in patients with breast cancer","volume":"16","author":"Arrington","year":"2009","journal-title":"Ann. Surg Oncol."},{"issue":"6","key":"10.1016\/j.ijsu.2017.12.022_bib34","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s10434-999-0542-1","article-title":"Issues of regret in women with contralateral prophylactic mastectomies","volume":"6","author":"Montgomery","year":"1999","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.ijsu.2017.12.022_bib35","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1245\/s10434-014-3588-7","article-title":"Cost-effectiveness of contralateral prophylactic mastectomy for prevention of contralateral breast cancer","volume":"21","author":"Roberts","year":"2014","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.ijsu.2017.12.022_bib36","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1200\/JCO.2011.35.6956","article-title":"Cost-effectiveness of contralateral prophylactic mastectomy versus routine surveillance in patients with unilateral breast cancer","volume":"29","author":"Zendejas","year":"2011","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.ijsu.2017.12.022_bib37","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1177\/1049732314557085","article-title":"Redefining risk and benefit: understanding the decision to undergo contralateral prophylactic mastectomy","volume":"25","author":"Rendle","year":"2015","journal-title":"Qual. Health Res."},{"issue":"5","key":"10.1016\/j.ijsu.2017.12.022_bib38","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.amjsurg.2011.01.018","article-title":"Increasing incidence of bilateral mastectomies: the patient perspective","volume":"201","author":"Han","year":"2011","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.ijsu.2017.12.022_bib39","unstructured":"R. Kenny, G. Cant, V. Jenkins, L. Fallowfield, A. Subramanian, Evaluating the attitudes towards and reasons for contralateral prophylactic mastectomy following the diagnosis of breast cancer in a large patient group. Publication in preparation."},{"issue":"11","key":"10.1016\/j.ijsu.2017.12.022_bib40","article-title":"Prophylactic mastectomy for the prevention of breast cancer","author":"Lostumbo","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijsu.2017.12.022_bib41","series-title":"A National Audit of Provision and Outcomes of Mastectomy and Breast Reconstruction Surgery for Women in England","author":"National Mastectomy and Breast Reconstruction audit 2011","year":"2011"},{"issue":"4","key":"10.1016\/j.ijsu.2017.12.022_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/01.NCC.0000281733.40856.c4","article-title":"What women wish they knew before prophylactic mastectomy","volume":"30","author":"Rolnick","year":"2007","journal-title":"Cancer Nurs"},{"issue":"10","key":"10.1016\/j.ijsu.2017.12.022_bib43","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1245\/s10434-015-4758-y","article-title":"Contralateral prophylactic mastectomy: challenging considerations for the surgeon","volume":"22","author":"Angelos","year":"2015","journal-title":"Ann. Surg Oncol."},{"issue":"8","key":"10.1016\/j.ijsu.2017.12.022_bib44","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1586\/era.11.100","article-title":"When is contralateral mastectomy warranted in unilateral breast cancer?","volume":"11","author":"Barry","year":"2011","journal-title":"Expert Rev. Anticancer Ther."},{"issue":"11","key":"10.1016\/j.ijsu.2017.12.022_bib45","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/cncr.28996","article-title":"Risk assessment: physicians discuss motivations for rising rates of prophylactic mastectomies","volume":"121","author":"Printz","year":"2015","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ijsu.2017.12.022_bib46","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/SLA.0000000000001216","article-title":"Prospective study of surgical decision-making processes for contralateral prophylactic mastectomy in women with breast cancer","volume":"263","author":"Parker","year":"2016","journal-title":"Ann. Surg."}],"container-title":["International Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919117315017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743919117315017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T16:03:52Z","timestamp":1677081832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1743919117315017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":45,"alternative-id":["S1743919117315017"],"URL":"https:\/\/doi.org\/10.1016\/j.ijsu.2017.12.022","relation":{},"ISSN":["1743-9191"],"issn-type":[{"value":"1743-9191","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mastectomy for risk reduction or symmetry in women without high risk gene mutation: A review","name":"articletitle","label":"Article Title"},{"value":"International Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijsu.2017.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}