{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:41:28Z","timestamp":1761129688896,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"RNTCP"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Journal of Tuberculosis"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ijtb.2019.09.004","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:22:50Z","timestamp":1569237770000},"page":"474-479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phenotypic isoniazid resistance and associated mutations in pediatric tuberculosis"],"prefix":"10.1016","volume":"66","author":[{"given":"Sapna","family":"Jhanjhria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bineeta","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Gomber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneeta","family":"Hyanki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2018","series-title":"Global Tuberculosis Report 2018","author":"World Health Organization","key":"10.1016\/j.ijtb.2019.09.004_bib1"},{"year":"2017","series-title":"WHO Treatment Guidelines for Isoniazid-Resistant Tuberculosis","author":"World Health Organization","key":"10.1016\/j.ijtb.2019.09.004_bib2"},{"issue":"7","key":"10.1016\/j.ijtb.2019.09.004_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022927","article-title":"Quantifying the burden and trends of isoniazid resistant tuberculosis, 1994\u20132009","volume":"6","author":"Jenkins","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijtb.2019.09.004_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/AAC.2.1.29","article-title":"Effect of isoniazid on the in\u00a0vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis","volume":"2","author":"Takayama","year":"1972","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijtb.2019.09.004_bib5","first-page":"15","article-title":"Investigation of Ser315 substitutions within katG gene in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from south India","volume":"20","author":"Unissa","year":"2015","journal-title":"BioMed Res Int"},{"issue":"3","key":"10.1016\/j.ijtb.2019.09.004_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119628","article-title":"Genetic mutations associated with isoniazid resistance in Mycobacterium tuberculosis: a systematic review","volume":"10","author":"Seifert","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.ijtb.2019.09.004_bib7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.5588\/ijtld.15.0864","article-title":"Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis","volume":"20","author":"Bollela","year":"2016","journal-title":"Int J Tuberc Lung Dis"},{"issue":"5","key":"10.1016\/j.ijtb.2019.09.004_bib8","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1128\/AAC.01550-10","article-title":"Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis","volume":"55","author":"Campbell","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijtb.2019.09.004_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1471-2334-13-133","article-title":"Evaluation of the Xpert MTB\/RIF test for the diagnosis of childhood pulmonary tuberculosis in Uganda: a cross-sectional diagnostic study","volume":"13","author":"Sekadde","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijtb.2019.09.004_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2334-10-41","article-title":"Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda","volume":"10","author":"Albert","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijtb.2019.09.004_bib11","series-title":"Government of India. Revised National TB Control Programme Training Manual for Mycobacterium tuberculosis Culture & Drug Susceptibility Testing","first-page":"1","author":"Central TB Division","year":"2009"},{"issue":"1","key":"10.1016\/j.ijtb.2019.09.004_bib12","first-page":"57","article-title":"Detection of genomic mutations in katG, inhA and rpoB genes of Mycobacterium tuberculosis isolates using polymerase chain reaction and multiplex allele-specific polymerase chain reaction","volume":"16","author":"Khosravi","year":"2012","journal-title":"Brazilian J infect dis"},{"issue":"3","key":"10.1016\/j.ijtb.2019.09.004_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1179\/2046905515Y.0000000041","article-title":"Delhi Pediatric TB Study Group. High prevalence of primary drug resistance in children with intrathoracic tuberculosis in India","volume":"36","author":"Prajapati","year":"2016","journal-title":"Paediatr Int Child Health"},{"issue":"4","key":"10.1016\/j.ijtb.2019.09.004_bib14","first-page":"235","article-title":"Drug resistance pattern of Mycobacterium tuberculosis in seropositive and seronegative HIV-TB patients in Pune, India","volume":"121","author":"Pereira","year":"2005","journal-title":"Indian J Med Res"},{"issue":"2","key":"10.1016\/j.ijtb.2019.09.004_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/20469047.2016.1214796","article-title":"Changing prevalence and resistance patterns in children with drug-resistant tuberculosis in Mumbai","volume":"37","author":"Shah","year":"2017","journal-title":"Paediatr Int Child Health"},{"issue":"1","key":"10.1016\/j.ijtb.2019.09.004_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2334-11-28","article-title":"High prevalence of childhood multi-drug resistant tuberculosis in Johannesburg, South Africa: a cross sectional study","volume":"11","author":"Fairlie","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"5","key":"10.1016\/j.ijtb.2019.09.004_bib17","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1097\/INF.0b013e3182865409","article-title":"Isoniazid-resistant tuberculosis in children: a systematic review","volume":"32","author":"Yuen","year":"2013","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"10.1016\/j.ijtb.2019.09.004_bib18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1186\/s12889-015-1955-3","article-title":"Drug resistance patterns of Mycobacterium tuberculosis complex and associated factors among retreatment cases around Jimma, Southwest Ethiopia","volume":"15","author":"Abdella","year":"2015","journal-title":"BMC Public Health"},{"issue":"4","key":"10.1016\/j.ijtb.2019.09.004_bib19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/cid\/cir406","article-title":"Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa","volume":"53","author":"Jacobson","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.ijtb.2019.09.004_bib20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jinf.2010.03.017","article-title":"Isoniazid-resistant tuberculosis in Denmark: mutations, transmission and treatment outcome","volume":"60","author":"Bang","year":"2010","journal-title":"J Infect"},{"issue":"2","key":"10.1016\/j.ijtb.2019.09.004_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1086\/595689","article-title":"Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis","volume":"48","author":"Cattamanchi","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijtb.2019.09.004_bib22","first-page":"1320","article-title":"Mechanisms of drug resistance in Mycobacterium tuberculosis","volume":"13","author":"Zhang","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.ijtb.2019.09.004_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3201\/eid0402.980207","article-title":"Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives","volume":"4","author":"Rattan","year":"1998","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"10.1016\/j.ijtb.2019.09.004_bib24","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1128\/AAC.00077-13","article-title":"Epidemiology of isoniazid resistance mutations and their effect on tuberculosis treatment outcomes","volume":"57","author":"Huyen","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.ijtb.2019.09.004_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2018-000971","article-title":"Drug-resistant tuberculosis: is India ready for the challenge?","volume":"3","author":"Chatterjee","year":"2018","journal-title":"BMJ global health"}],"container-title":["Indian Journal of Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019570719303166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019570719303166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:58:30Z","timestamp":1758081510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0019570719303166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0019570719303166"],"URL":"https:\/\/doi.org\/10.1016\/j.ijtb.2019.09.004","relation":{},"ISSN":["0019-5707"],"issn-type":[{"type":"print","value":"0019-5707"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic isoniazid resistance and associated mutations in pediatric tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Indian Journal of Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijtb.2019.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}