{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:35:37Z","timestamp":1772991337215,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Journal of Tuberculosis"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ijtb.2021.06.006","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T12:54:26Z","timestamp":1623761666000},"page":"341-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A prospective observational study to evaluate Glutathione S-transferase gene polymorphism and its association with Antitubercular drugs induced liver injury in tertiary hospital"],"prefix":"10.1016","volume":"69","author":[{"given":"Javed","family":"Akhtar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarvesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra","family":"Nath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijtb.2021.06.006_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0041-3879(77)90022-8","article-title":"The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide","volume":"59","author":"Girling","year":"1977","journal-title":"Tubercle"},{"key":"10.1016\/j.ijtb.2021.06.006_bib2","first-page":"479","article-title":"Antituberculosis treatment-induced Hepatotoxicity: from bench to bedside","author":"Sharma","year":"2005","journal-title":"Medicine update"},{"issue":"3","key":"10.1016\/j.ijtb.2021.06.006_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/01480549709003881","article-title":"Study of oxidative-stress in isoniazid-rifampicin induced hepatic injury in young rats","volume":"20","author":"Sodhi","year":"1997","journal-title":"Drug Chem Toxicol"},{"issue":"4596","key":"10.1016\/j.ijtb.2021.06.006_bib4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.6836290","article-title":"Selective modification of glutathione metabolism","volume":"220","author":"Meister","year":"1983","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.ijtb.2021.06.006_bib5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1096\/fasebj.1.3.2887478","article-title":"Glutathione, a first line of defense against cadmium toxicity","volume":"1","author":"Singhal","year":"1987","journal-title":"Faseb J"},{"issue":"3","key":"10.1016\/j.ijtb.2021.06.006_bib6","first-page":"182","article-title":"Role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury","volume":"108","author":"Andreoli","year":"1986","journal-title":"J Lab Clin Med"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/bj2740409","article-title":"Theta, a new class of glutathione transferases purified from rat and man","volume":"274","author":"Meyer","year":"1991","journal-title":"Biochem J"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/03602532.2011.558093","article-title":"Glutathione transferases: a structural perspective","volume":"43","author":"Oakley","year":"2011","journal-title":"Drug Metab Rev"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"10.1016\/j.ijtb.2021.06.006_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj3000271","article-title":"Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism","volume":"300","author":"Pemble","year":"1994","journal-title":"Biochem J"},{"issue":"3","key":"10.1016\/j.ijtb.2021.06.006_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/01480540903449715","article-title":"Xanthine oxidase inhibition by allopurinol increases in\u00a0vitro pyrazinamide-induced hepatotoxicity in HepG2 cells","volume":"33","author":"Tostmann","year":"2010","journal-title":"Drug Chem Toxicol"},{"issue":"5","key":"10.1016\/j.ijtb.2021.06.006_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMra021844","article-title":"Drug-induced hepatotoxicity","volume":"349","author":"Lee","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijtb.2021.06.006_bib13","first-page":"143","article-title":"Drug-induced liver disease","volume":"vol. 16","author":"Farrell","year":"1996"},{"issue":"9-10","key":"10.1016\/j.ijtb.2021.06.006_bib14","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1111\/j.1440-1746.1997.tb00507.x","article-title":"Drug-induced hepatic injury","volume":"12","author":"Farrell","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1378\/chest.68.2.181","article-title":"Acetylation rates and monthly liver function tests during one year of isoniazid preventive therapy","volume":"68","author":"Mitchell","year":"1975","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ijtb.2021.06.006_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-79-1-1","article-title":"Isoniazid hepatitis","volume":"79","author":"Maddrey","year":"1973","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.meegid.2003.01.001","article-title":"Antituberculosis drugs and hepatotoxicity","volume":"4","author":"Sharma","year":"2004","journal-title":"Infect Genet Evol"},{"issue":"5","key":"10.1016\/j.ijtb.2021.06.006_bib18","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1172\/JCI116064","article-title":"Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes","volume":"90","author":"Kolars","year":"1992","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.ijtb.2021.06.006_bib19","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1128\/AAC.01866-12","article-title":"A novel mechanism underlies the hepatotoxicity of pyrazinamide","volume":"57","author":"Shih","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1440-1746.2007.05207.x","article-title":"Antituberculosis drug-induced hepatotoxicity: concise up-to-date review","volume":"23","author":"Tostmann","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.ijtb.2021.06.006_bib21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1440-1746.2001.02585.x","article-title":"Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 \u2018null\u2019mutation","volume":"16","author":"Roy","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.ijtb.2021.06.006_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jcpt.12105","article-title":"N-acetyltransferase 2, cytochrome P 4502 E 1 and glutathione S-transferase genotypes in antitubercular treatment-induced hepatotoxicity in North Indians","volume":"39","author":"Rana","year":"2014","journal-title":"J Clin Pharm Therapeut"},{"issue":"5","key":"10.1016\/j.ijtb.2021.06.006_bib23","first-page":"803","article-title":"Association of isoniazid-metabolizing enzyme genotypes and isoniazid-induced hepatotoxicity in tuberculosis patients","volume":"25","author":"Sotsuka","year":"2011","journal-title":"In\u00a0vivo"},{"issue":"1","key":"10.1016\/j.ijtb.2021.06.006_bib24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2007.02.009","article-title":"Genetic polymorphisms of manganese superoxide dismutase, NAD (P) H: quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury","volume":"47","author":"Huang","year":"2007","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.ijtb.2021.06.006_bib25","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jgh.12194","article-title":"Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India","volume":"28","author":"Gupta","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.ijtb.2021.06.006_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tube.2014.02.003","article-title":"Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity","volume":"94","author":"Singla","year":"2014","journal-title":"Tuberculosis"},{"issue":"4","key":"10.1016\/j.ijtb.2021.06.006_bib27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2710.2009.01101.x","article-title":"GSTT1 and GSTM1 gene deletions are not associated with hepatotoxicity caused by antitubercular drugs","volume":"35","author":"Chatterjee","year":"2010","journal-title":"J Clin Pharm Therapeut"},{"issue":"5","key":"10.1016\/j.ijtb.2021.06.006_bib28","doi-asserted-by":"crossref","first-page":"588","DOI":"10.5588\/ijtld.13.0344","article-title":"Genetic polymorphisms of CYP2E1 and GSTM1 loci and susceptibility to anti-tuberculosis drug-induced hepatotoxicity","volume":"18","author":"Sharma","year":"2014","journal-title":"Int J Tubercul Lung Dis"},{"issue":"6","key":"10.1016\/j.ijtb.2021.06.006_bib29","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1590\/S0074-02762011000600011","article-title":"Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients","volume":"106","author":"Teixeira","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"6","key":"10.1016\/j.ijtb.2021.06.006_bib30","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1365-2710.2012.01368.x","article-title":"The roles of GSTM1 and GSTT1 null genotypes and other predictors in anti-tuberculosis drug-induced liver injury","volume":"37","author":"Monteiro","year":"2012","journal-title":"J Clin Pharm Therapeut"},{"issue":"2","key":"10.1016\/j.ijtb.2021.06.006_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1517\/14740338.5.2.231","article-title":"Adverse reactions to first-line antituberculosis drugs","volume":"5","author":"Forget","year":"2006","journal-title":"Expet Opin Drug Saf"}],"container-title":["Indian Journal of Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019570721001116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019570721001116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:00:16Z","timestamp":1758081616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0019570721001116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0019570721001116"],"URL":"https:\/\/doi.org\/10.1016\/j.ijtb.2021.06.006","relation":{},"ISSN":["0019-5707"],"issn-type":[{"value":"0019-5707","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A prospective observational study to evaluate Glutathione S-transferase gene polymorphism and its association with Antitubercular drugs induced liver injury in tertiary hospital","name":"articletitle","label":"Article Title"},{"value":"Indian Journal of Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijtb.2021.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V. on behalf of Tuberculosis Association of India.","name":"copyright","label":"Copyright"}]}}