{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:51:20Z","timestamp":1773366680617,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Journal of Tuberculosis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijtb.2025.07.009","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:46:26Z","timestamp":1754549186000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A diagnostic study of pulmonary and extra pulmonary tuberculosis by GeneXpert MTB\/RIF assay in pediatric population"],"prefix":"10.1016","volume":"73","author":[{"given":"Raj Narayan","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manpreet","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yellanki Yashwanth","family":"Chowdary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajoy Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.K.","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijtb.2025.07.009_bib2","series-title":"Central TB Division","year":"2024"},{"key":"10.1016\/j.ijtb.2025.07.009_bib3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12098-023-04910-4","article-title":"Current epidemiology of pediatric tuberculosis","volume":"91","author":"Mane","year":"2023","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ijtb.2025.07.009_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s12098-023-04992-0","article-title":"What is new in the diagnosis of childhood tuberculosis?","volume":"91","author":"Rodrigues","year":"2024","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ijtb.2025.07.009_bib5","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1128\/JCM.39.8.2987-2990.2001","article-title":"Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India","volume":"39","author":"Mani","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijtb.2025.07.009_bib6","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/j.ijmyco.2016.09.007","article-title":"Evaluation of rifampicin resistance and 81-bp rifampicin resistant determinant region of rpoB gene mutations of Mycobacterium tuberculosis detected with XpertMTB\/Rif in Cross River State, Nigeria","volume":"5","author":"Ochang","year":"2016","journal-title":"Int J Mycobacteriol"},{"key":"10.1016\/j.ijtb.2025.07.009_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0140-6736(93)90417-F","article-title":"Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis","volume":"341","author":"Telenti","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ijtb.2025.07.009_bib8","first-page":"96","article-title":"Epidemiology of Rifampicin resistant tuberculosis and common mutations in rpoB gene of mycobacterium tuberculosis: a retrospective study from six districts of Punjab (India) using Xpert MTB\/RIF assay","volume":"8","author":"Kaur","year":"2016","journal-title":"J Lab Phys"},{"key":"10.1016\/j.ijtb.2025.07.009_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijtb.2018.08.002","article-title":"Pattern of missing probes in rifampicin resistant TB by Xpert MTB\/RIF assay at a tertiary care centre in Mumbai","volume":"66","author":"Kanade","year":"2019","journal-title":"Indian J Tubercul"},{"key":"10.1016\/j.ijtb.2025.07.009_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2022.102182","article-title":"Characterization of probes associated with rifampicin resistance in M.tuberculosis detected by GenXpert from a national reference laboratory at Chennai","volume":"133","author":"Rajendran","year":"2022","journal-title":"Tuberculosis"},{"key":"10.1016\/j.ijtb.2025.07.009_bib11","first-page":"33","article-title":"Identification of missing probes in rpoB gene in Rifampicin resistant PTB and EPTB cases using Xpert MTB\/RIF assay in sirmaur, Himachal Pradesh","volume":"68","author":"Kumar","year":"2020","journal-title":"PubMed"},{"key":"10.1016\/j.ijtb.2025.07.009_bib12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1183\/09031936.00089808","article-title":"Mechanisms of heteroresistance to isoniazid and rifampin of Mycobacterium tuberculosis in Tashkent, Uzbekistan","volume":"33","author":"Hofmann-Thiel","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijtb.2025.07.009_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2991\/jegh.k.191215.002","article-title":"Utility of Xpert MTB\/RIF assay for diagnosis of pediatric tuberculosis under programmatic conditions in India","volume":"10","author":"Yadav","year":"2020","journal-title":"J Epidemiol Glob Health"},{"key":"10.1016\/j.ijtb.2025.07.009_bib14","unstructured":"National strategic plan 2017-2025 for TB elimination in India :: central TB division. n.d. https:\/\/tbcindia.gov.in\/index1.php?lang=1&level=2&sublinkid=5450&lid=3266."},{"issue":"9","key":"10.1016\/j.ijtb.2025.07.009_bib16","article-title":"Sexual dimorphism in tuberculosis incidence: children cases compared to adult cases in Tuscany from 1997 to 2011","volume":"9","author":"Stival","year":"2014","journal-title":"Plose One"},{"issue":"5","key":"10.1016\/j.ijtb.2025.07.009_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pedneo.2013.01.019","article-title":"Childhood tuberculosis: epidemiology, diagnosis, treatment, and vaccination","volume":"54","author":"Tsai","year":"2013","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.ijtb.2025.07.009_bib18","doi-asserted-by":"crossref","unstructured":"Thakur S, Chauhan V, Kumar R, Beri G. Adolescent females are more susceptible than males for tuberculosis J Global Infect Dis;13:3-6.","DOI":"10.4103\/jgid.jgid_229_20"},{"key":"10.1016\/j.ijtb.2025.07.009_bib19","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.2147\/IDR.S433789","article-title":"Pulmonary Tuberculosis and rifampicin resistant Mycobacterium Tuberculosis in children and adolescents using gene Xpert MTB\/RIF assay in Tigray, Northern Ethiopia","volume":"16","author":"Dejene","year":"2023","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.ijtb.2025.07.009_bib20","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1007\/s00431-023-04988-0","article-title":"Risk factors for the development of tuberculosis among the pediatric population: a systematic review and meta-analysis","volume":"182","author":"Siddalingaiah","year":"2023","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ijtb.2025.07.009_bib21","doi-asserted-by":"crossref","unstructured":"Peer V, Schwartz N, Green MS. Gender differences in tuberculosis incidence rates- A pooled analysis of data from seven high-income countries by age group and time period. Front Public Health 10:997025 doi: 10.3389\/fpubh.2023.1157235.","DOI":"10.3389\/fpubh.2022.997025"},{"issue":"4","key":"10.1016\/j.ijtb.2025.07.009_bib22","first-page":"423","article-title":"Comparison of clinical and laboratory profile of pulmonary and extrapulmonary tuberculosis in children: a single-center experience from India","volume":"7","author":"Singh","year":"2021","journal-title":"J Clin Transl Res"},{"issue":"9","key":"10.1016\/j.ijtb.2025.07.009_bib23","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.it.2023.07.003","article-title":"Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye","volume":"44","author":"Bobba","year":"2023","journal-title":"Trends Immunol"},{"issue":"1","key":"10.1016\/j.ijtb.2025.07.009_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-021-05933-y","article-title":"Sputum smear grading and associated factors among bacteriologically confirmed pulmonary drug-resistant tuberculosis patients in Ethiopia","volume":"21","author":"Kassa","year":"2021","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijtb.2025.07.009_bib25","year":"2018","journal-title":"Global Tuberculosis Report"},{"issue":"4","key":"10.1016\/j.ijtb.2025.07.009_bib26","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.1016\/S2666-5247(23)00367-1","article-title":"Accuracy of the tuberculosis molecular bacterial load assay to diagnose and monitor response to anti-tuberculosis therapy: a longitudinal comparative study with standard-of-care smear microscopy, Xpert MTB\/RIF Ultra, and culture in Uganda","volume":"5","author":"Musisi","year":"2024","journal-title":"The Lancet Microbe [Internet]"},{"issue":"7","key":"10.1016\/j.ijtb.2025.07.009_bib27","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/thoraxjnl-2019-214238","article-title":"Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay","volume":"75","author":"Sabiiti","year":"2020","journal-title":"Thorax"},{"key":"10.1016\/j.ijtb.2025.07.009_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2019.101864","article-title":"Comparison of the Mycobacterium tuberculosis molecular bacterial load assay, microscopy and GeneXpert versus liquid culture for viable bacterial load quantification before and after starting pulmonary tuberculosis treatment","volume":"119","author":"Hai","year":"2019","journal-title":"Tuberculosis"},{"key":"10.1016\/j.ijtb.2025.07.009_bib29","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1038\/s41598-017-06517-0","article-title":"GeneXpert MTB\/RIF assay in the diagnosis of urinary tuberculosis from urine specimens","volume":"7","author":"Pang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijtb.2025.07.009_bib30","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm.161.4.16141","article-title":"Diagnostic standards and classification of tuberculosis in adults and children","volume":"161","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.ijtb.2025.07.009_bib31","first-page":"319","article-title":"Laboratory diagnosis of tuberculosis: conventional and newer","volume":"9","author":"Yadav","year":"2020","journal-title":"Methods"},{"key":"10.1016\/j.ijtb.2025.07.009_bib32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijtb.2021.02.014","article-title":"Drug resistance pattern and mutation pattern in pediatric tuberculosis: study from North India","volume":"68","author":"Khurana","year":"2021","journal-title":"Indian J Tubercul"},{"key":"10.1016\/j.ijtb.2025.07.009_bib33","article-title":"A comparative evaluation of the new Genexpert MTB\/RIF ultra and other rapid diagnostic assays for detecting tuberculosis in pulmonary and extra pulmonary specimens","volume":"9","author":"Sekyere","year":"2019","journal-title":"Sci Rep"}],"container-title":["Indian Journal of Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019570725001787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019570725001787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:39:36Z","timestamp":1773322776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0019570725001787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0019570725001787"],"URL":"https:\/\/doi.org\/10.1016\/j.ijtb.2025.07.009","relation":{},"ISSN":["0019-5707"],"issn-type":[{"value":"0019-5707","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A diagnostic study of pulmonary and extra pulmonary tuberculosis by GeneXpert MTB\/RIF assay in pediatric population","name":"articletitle","label":"Article Title"},{"value":"Indian Journal of Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijtb.2025.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Tuberculosis Association of India.","name":"copyright","label":"Copyright"}]}}