{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:20:04Z","timestamp":1767147604045,"version":"build-2238731810"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2019-I2M-5-056"],"award-info":[{"award-number":["2019-I2M-5-056"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iLIVER"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.iliver.2022.01.001","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T06:37:31Z","timestamp":1646894251000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploratory study of microparticle transcatheter arterial chemoembolization combined with resection for huge hepatocellular carcinoma"],"prefix":"10.1016","volume":"1","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanqi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canhong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuedong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuewei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.iliver.2022.01.001_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155588","article-title":"Solitary large hepatocellular carcinoma: staging and treatment strategy[J]","volume":"11","author":"Liu","year":"2016","journal-title":"PLos One"},{"issue":"11","key":"10.1016\/j.iliver.2022.01.001_bib2","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/bjs.10196","article-title":"Long-term survival of patients undergoing liver resection for very large hepatocellular carcinomas[J]","volume":"103","author":"Chang","year":"2016","journal-title":"Br J Surg"},{"issue":"6","key":"10.1016\/j.iliver.2022.01.001_bib3","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.hbpd.2019.09.001","article-title":"Long-term outcomes after hepatectomy of huge hepatocellular carcinoma: a single-center experience in China[J]","volume":"18","author":"Fang","year":"2019","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"3","key":"10.1016\/j.iliver.2022.01.001_bib4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/jso.24501","article-title":"Huge hepatocellular carcinoma greater than 10 cm in diameter worsens prognosis by causing distant recurrence after curative resection[J]","volume":"115","author":"Wakayama","year":"2017","journal-title":"J\u00a0Surg Oncol"},{"issue":"3","key":"10.1016\/j.iliver.2022.01.001_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12032-015-0504-3","article-title":"Transarterial chemoembolization for huge hepatocellular carcinoma with diameter over ten centimeters: a large cohort study[J]","volume":"32","author":"Xue","year":"2015","journal-title":"Med Oncol"},{"key":"10.1016\/j.iliver.2022.01.001_bib6","doi-asserted-by":"crossref","first-page":"2754542","DOI":"10.1155\/2016\/2754542","article-title":"Treatment of huge hepatocellular carcinoma using cinobufacini injection in transarterial chemoembolization: a retrospective study[J]","author":"Dong","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"issue":"7","key":"10.1016\/j.iliver.2022.01.001_bib7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/hepr.13335","article-title":"Outcomes of conventional transarterial chemoembolization for hepatocellular carcinoma \u226510 cm[J]","volume":"49","author":"Miyayama","year":"2019","journal-title":"Hepatol Res"},{"issue":"1","key":"10.1016\/j.iliver.2022.01.001_bib8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12029-019-00240-x","article-title":"Prognostic factors and survival outcomes of surgical resection of huge hepatocellular carcinomas [J]","volume":"51","author":"Bhanu","year":"2020","journal-title":"J\u00a0Gastrointest Cancer"},{"issue":"10","key":"10.1016\/j.iliver.2022.01.001_bib9","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1007\/s00268-015-3129-y","article-title":"Long-term outcome after resection of huge hepatocellular carcinoma \u2265 10 cm: single-institution experience with 471 patients[J]","volume":"39","author":"Hwang","year":"2015","journal-title":"World J Surg"},{"issue":"6","key":"10.1016\/j.iliver.2022.01.001_bib10","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s12072-019-09981-0","article-title":"Preoperative transcatheter arterial chemoembolization for surgical resection of hugehepatocellular carcinoma (\u2265 10 cm):a multicenter propensity matching analysis[J]","volume":"13","author":"Li","year":"2019","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.iliver.2022.01.001_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3892\/ijo.2012.1711","article-title":"Effect of transcatheter arterial chemoembolization prior to surgical resection for hepatocellular carcinoma[J]","volume":"42","author":"Nishikawa","year":"2013","journal-title":"Int J Oncol"},{"issue":"4","key":"10.1016\/j.iliver.2022.01.001_bib12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jso.23098","article-title":"Beneficial effects of preoperative lipiodolization for resectable large hepatocellular carcinoma (\u2265 5 cm in diameter) [J]","volume":"106","author":"Yamashita","year":"2012","journal-title":"J\u00a0Surg Oncol"},{"issue":"2","key":"10.1016\/j.iliver.2022.01.001_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/SLA.0b013e3181961c16","article-title":"A\u00a0prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma[J]","volume":"249","author":"Zhou","year":"2009","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.iliver.2022.01.001_bib14","first-page":"523","article-title":"Influence of preoperative transcatheter arterial chemoembolization on liver resection in patients with resectable hepatocellular carcinoma","volume":"1","author":"Luo","year":"2002","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"12","key":"10.1016\/j.iliver.2022.01.001_bib15","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1007\/s00268-007-9245-6","article-title":"Is preoperative transarterial chemoembolization needed for a resectable hepatocellular carcinoma?[J]","volume":"31","author":"Choi","year":"2007","journal-title":"World J Surg"},{"issue":"4","key":"10.1016\/j.iliver.2022.01.001_bib16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2036.2007.03580.x","article-title":"Preoperative transarterial chemoembolization for resectable hepatocellular carcinoma adversely affects post-operative patient outcome[J]","volume":"27","author":"Kim","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.iliver.2022.01.001_bib17","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.jhep.2015.01.022","article-title":"Complete response at first chemoembolization is still the most robust predictor for favorable outcome in hepatocellular carcinoma[J]","volume":"62","author":"Kim","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.iliver.2022.01.001_bib18","first-page":"4692139","article-title":"Does the degree of hepatocellular carcinoma tumor necrosis following transarterial chemoembolization impact patient survival?[J]","author":"Haywood","year":"2016","journal-title":"J\u00a0Oncol"},{"issue":"6","key":"10.1016\/j.iliver.2022.01.001_bib19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/00000658-199712000-00006","article-title":"Influence of preoperative transarterial lipiodol chemoembolization on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis[J]","volume":"226","author":"Majno","year":"1997","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.iliver.2022.01.001_bib20","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4103\/jcrt.JCRT_297_17","article-title":"Transarterial chemoembolization with gelatin sponge microparticles for barcelona clinic liver cancer Stage C and large hepatocellular carcinoma: initial clinical experience[J]","volume":"13","author":"Zhou","year":"2017","journal-title":"J\u00a0Cancer Res Ther"},{"issue":"1","key":"10.1016\/j.iliver.2022.01.001_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12013-014-0167-2","article-title":"Trans-arterial p53-gene-embolization with gelatin sponge microparticles for hepatocellular carcinoma with BCLC stage B: single-center experience[J]","volume":"71","author":"Liu","year":"2015","journal-title":"Cell Biochem Biophys"},{"issue":"5","key":"10.1016\/j.iliver.2022.01.001_bib22","first-page":"280","article-title":"Effect of gelatin sponge particle TACE on myeloid derived inhibitory cells in peripheral blood of Barcelona stage B hepatocellular carcinoma[J]","volume":"16","author":"Yue","year":"2019","journal-title":"Chin J Interventional Imaging Ther"},{"key":"10.1016\/j.iliver.2022.01.001_bib23","doi-asserted-by":"crossref","first-page":"624789","DOI":"10.3389\/fimmu.2021.624789","article-title":"Changes in the peripheral blood treg cell proportion in hepatocellular carcinoma patients after transarterial chemoembolization with microparticles[J]","volume":"12","author":"Ren","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.iliver.2022.01.001_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) [J]","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.iliver.2022.01.001_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jhep.2006.10.020","article-title":"Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics[J]","volume":"46","author":"Varela","year":"2007","journal-title":"J\u00a0Hepatol"},{"issue":"8","key":"10.1016\/j.iliver.2022.01.001_bib26","first-page":"637","article-title":"Effect of transcatheter arterial chemoembolization with gelatin sponge particles on primary liver cancer[J]","volume":"21","author":"Zhang","year":"2013","journal-title":"Chin J Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2022.01.001_bib27","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1186\/s12885-019-6386-6","article-title":"Conventional versus drug-eluting beads chemoembolization for infiltrative hepatocellular carcinoma: a comparison of efficacy and safety[J]","volume":"19","author":"Zhang","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.iliver.2022.01.001_bib28","first-page":"3682614","article-title":"Complete remission after sequential therapy of drug eluting beads transarterial chemoembolization and liver resection in large solitary nodule hepatocellular carcinoma[J]","author":"Kurniawan","year":"2017","journal-title":"Case Reports Hepatol"},{"issue":"5","key":"10.1016\/j.iliver.2022.01.001_bib29","first-page":"415","article-title":"New gelatin sponge particles TACE in the treatment of liver abscess after primary liver cancer and literature review[J]","volume":"22","author":"Zhang","year":"2013","journal-title":"J\u00a0Interv Radiol"},{"issue":"5","key":"10.1016\/j.iliver.2022.01.001_bib30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jhep.2013.06.015","article-title":"Radiation lobectomy: time-dependent analysis of future liver remnant volume in unresectable liver cancer as a bridge to resection[J]","volume":"59","author":"Vouche","year":"2013","journal-title":"J\u00a0Hepatol"},{"issue":"9","key":"10.1016\/j.iliver.2022.01.001_bib31","article-title":"Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy[J]","volume":"9","author":"Pinato","year":"2021","journal-title":"J\u00a0Immunother Cancer"}],"updated-by":[{"DOI":"10.1016\/j.iliver.2025.100157","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000}}],"container-title":["iLIVER"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772947822000019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772947822000019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:31:20Z","timestamp":1762648280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772947822000019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S2772947822000019"],"URL":"https:\/\/doi.org\/10.1016\/j.iliver.2022.01.001","relation":{},"ISSN":["2772-9478"],"issn-type":[{"value":"2772-9478","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploratory study of microparticle transcatheter arterial chemoembolization combined with resection for huge hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"iLIVER","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iliver.2022.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd on behalf of Tsinghua University Press.","name":"copyright","label":"Copyright"}]}}