{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:07:54Z","timestamp":1778936874497,"version":"3.51.4"},"reference-count":106,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100500"],"award-info":[{"award-number":["2021YFA1100500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930016"],"award-info":[{"award-number":["81930016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92159202"],"award-info":[{"award-number":["92159202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000617"],"award-info":[{"award-number":["82000617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iLIVER"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.iliver.2022.08.003","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T15:48:31Z","timestamp":1661874511000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced therapies for congenital biliary tract malformation: From bench to bedside"],"prefix":"10.1016","volume":"1","author":[{"given":"Yixuan","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-2811","authenticated-orcid":false,"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.iliver.2022.08.003_bib1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.29905","article-title":"Biliary atresia: clinical and research challenges for the twenty-first century","volume":"68","author":"Bezerra","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib2","series-title":"StatPearls, treasure island (FL)","article-title":"Alagille syndrome","author":"Diaz-Frias","year":"2022"},{"key":"10.1016\/j.iliver.2022.08.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2016.06.005","article-title":"Biliary atresia: a comprehensive review","volume":"73","author":"Lakshminarayanan","year":"2016","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.iliver.2022.08.003_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1750-1172-8-128","article-title":"Aetiology of biliary atresia: what is actually known?","volume":"8","author":"Petersen","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.iliver.2022.08.003_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/01.mpg.0000304465.60788.f4","article-title":"CFC1 gene involvement in biliary atresia with polysplenia syndrome","volume":"46","author":"Davit-Spraul","year":"2008","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib6","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.jpedsurg.2007.12.058","article-title":"Cystic biliary atresia: an etiologic and prognostic subgroup","volume":"43","author":"Caponcelli","year":"2008","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib7","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jpedsurg.2015.02.005","article-title":"Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome","volume":"50","author":"Hill","year":"2015","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib8","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","article-title":"Biliary atresia","volume":"374","author":"Hartley","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.iliver.2022.08.003_bib9","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1093\/hmg\/ddq196","article-title":"Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2","volume":"19","author":"Garcia-Barcel\u00f3","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.iliver.2022.08.003_bib10","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/ajmg.a.33332","article-title":"Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3","volume":"152A","author":"Leyva-Vega","year":"2010","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.iliver.2022.08.003_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/MOG.0000000000000509","article-title":"Genetics in biliary atresia","volume":"35","author":"Girard","year":"2019","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.iliver.2022.08.003_bib12","first-page":"67","article-title":"Variants associated with infantile cholestatic syndromes detected in extrahepatic biliary atresia by whole exome studies: a 20-case series from Thailand","volume":"7","author":"Sangkhathat","year":"2018","journal-title":"J\u00a0Pediatr Genet"},{"key":"10.1016\/j.iliver.2022.08.003_bib13","series-title":"L\u2019atresie des voies biliaires intrahepatiques avec voies biliaires extrahepatiques permeables chez l\u2019enfant","first-page":"301","author":"Alagille","year":"1969"},{"key":"10.1016\/j.iliver.2022.08.003_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41575-019-0156-4","article-title":"Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases","volume":"16","author":"Fabris","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.iliver.2022.08.003_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1086\/505332","article-title":"NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway","volume":"79","author":"McDaniell","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.iliver.2022.08.003_bib16","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.jpedsurg.2019.04.022","article-title":"Outcomes of liver transplantation for Alagille syndrome after Kasai portoenterostomy: Alagille Syndrome with agenesis of extrahepatic bile ducts at porta hepatis","volume":"54","author":"Gunadi","year":"2019","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143939","article-title":"Alagille syndrome mimicking biliary atresia in early infancy","volume":"10","author":"D\u011bdi\u010d","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.iliver.2022.08.003_bib18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41436-020-00989-8","article-title":"Genome sequencing increases diagnostic yield in clinically diagnosed Alagille syndrome patients with previously negative test results","volume":"23","author":"Rajagopalan","year":"2021","journal-title":"Genet Med"},{"key":"10.1016\/j.iliver.2022.08.003_bib19","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3348\/kjr.2019.0824","article-title":"Assessment of diffusion tensor imaging parameters of hepatic parenchyma for differentiation of biliary atresia from Alagille syndrome","volume":"21","author":"Abdel Razek","year":"2020","journal-title":"Korean J Radiol"},{"key":"10.1016\/j.iliver.2022.08.003_bib20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00383-018-4316-3","article-title":"Outcomes of Alagille syndrome following the Kasai operation: a systematic review and meta-analysis","volume":"34","author":"Fujishiro","year":"2018","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.iliver.2022.08.003_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/hep.510290331","article-title":"Features of Alagille syndrome in 92 patients: frequency and relation to prognosis","volume":"29","author":"Emerick","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MPG.0b013e3181df5fd8","article-title":"Effect of Kasai procedure on hepatic outcome in Alagille syndrome","volume":"51","author":"Kaye","year":"2010","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fmed.2020.00149","article-title":"Pediatric cholestatic liver disease: review of bile acid metabolism and discussion of current and emerging therapies","volume":"7","author":"Kriegermeier","year":"2020","journal-title":"Front Med"},{"key":"10.1016\/j.iliver.2022.08.003_bib24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.21037\/tp.2016.10.08","article-title":"Adjuvant treatments for biliary atresia","volume":"9","author":"Burns","year":"2020","journal-title":"Transl Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-230X-8-47","article-title":"Bile composition in Alagille syndrome and PFIC patients having partial external biliary diversion","volume":"8","author":"Emerick","year":"2008","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.iliver.2022.08.003_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/petr.13579","article-title":"Living donor liver transplantation in Alagille syndrome-Single center experience from south Asia","volume":"23","author":"Valamparampil","year":"2019","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/lt.24640","article-title":"Biliary atresia: indications and timing of liver transplantation and optimization of pretransplant care","volume":"23","author":"Sundaram","year":"2017","journal-title":"Liver Transpl"},{"key":"10.1016\/j.iliver.2022.08.003_bib28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jpeds.2005.12.054","article-title":"A\u00a0multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000","volume":"148","author":"Shneider","year":"2006","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jpeds.2011.03.004","article-title":"Hepatocellular carcinoma in biliary atresia: king's College Hospital experience","volume":"159","author":"Had\u017ei\u0107","year":"2011","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/MCG.0000000000000013","article-title":"Native liver histology after successful portoenterostomy in biliary atresia","volume":"48","author":"Lampela","year":"2014","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.iliver.2022.08.003_bib31","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.surg.2017.04.013","article-title":"Molecular signature of active fibrogenesis prevails in biliary atresia after successful portoenterostomy","volume":"162","author":"Kerola","year":"2017","journal-title":"Surgery"},{"key":"10.1016\/j.iliver.2022.08.003_bib32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/MPG.0000000000002446","article-title":"Management of biliary atresia in France 1986 to 2015: long-term results","volume":"69","author":"Fanna","year":"2019","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib33","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jpedsurg.2017.08.048","article-title":"Outcomes of biliary atresia in the Nordic countries - a multicenter study of 158 patients during 2005-2016","volume":"53","author":"Pakarinen","year":"2018","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.hbpd.2020.12.007","article-title":"SOX9 in biliary atresia: new insight for fibrosis progression","volume":"20","author":"El-Araby","year":"2021","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.iliver.2022.08.003_bib35","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s00383-017-4173-5","article-title":"Liver transplantation for biliary atresia: a systematic review","volume":"33","author":"Kasahara","year":"2017","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.iliver.2022.08.003_bib36","first-page":"4969","article-title":"Liver transplantation for biliary atresia in adulthood: single-centre surgical experience","volume":"10","author":"Cortes-Cerisuelo","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"22","key":"10.1016\/j.iliver.2022.08.003_bib37","first-page":"4","article-title":"Primary vs. salvage liver transplantation for biliary atresia: a retrospective cohort study","volume":"S0022\u20133468","author":"Yoeli","year":"2022","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/hep4.1468","article-title":"Outcomes of childhood cholestasis in Alagille syndrome: results of a multicenter observational study","volume":"4","author":"Kamath","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.iliver.2022.08.003_bib39","series-title":"Clinical features and outcomes in an international cohort of 731 Alagille syndrome patients from 19 countries","author":"Vandriel","year":"2019"},{"key":"10.1016\/j.iliver.2022.08.003_bib40","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00383-017-4174-4","article-title":"Biliary atresia and liver transplantation: results and thoughts for primary liver transplantation in select patients","volume":"33","author":"Superina","year":"2017","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.iliver.2022.08.003_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpeds.2005.04.073","article-title":"Biliary atresia: clinical profiles, risk factors, and outcomes of 755 patients listed for liver transplantation","volume":"147","author":"Utterson","year":"2005","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4103\/0366-6999.226901","article-title":"Outcomes of liver transplantation using pediatric deceased donor livers: a single-center analysis of 102 donors","volume":"131","author":"Zhang","year":"2018","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.iliver.2022.08.003_bib43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MPG.0000000000000986","article-title":"Liver transplantation for biliary atresia: is there a difference in outcome for infants?","volume":"62","author":"Arnon","year":"2016","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib44","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s11605-019-04188-y","article-title":"Short- and long-term outcomes after live-donor transplantation with hyper-reduced liver grafts in low-weight pediatric recipients","volume":"23","author":"Raices","year":"2019","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib45","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jss.2015.07.043","article-title":"Increased risk of vascular thrombosis in pediatric liver transplant recipients with thrombophilia","volume":"199","author":"Cha","year":"2015","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.iliver.2022.08.003_bib46","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/TP.0b013e31827a93b4","article-title":"Living-donor liver transplantation with hyperreduced left lateral segment grafts: a single-center experience","volume":"95","author":"Kanazawa","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.iliver.2022.08.003_bib47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/lt.24675","article-title":"Effects of recipient size and allograft type on pediatric liver transplantation for biliary atresia","volume":"23","author":"Alexopoulos","year":"2017","journal-title":"Liver Transpl"},{"key":"10.1016\/j.iliver.2022.08.003_bib48","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/ajt.15609","article-title":"Pediatric living donor liver transplantation with large-for-size left lateral segment grafts","volume":"20","author":"Goldaracena","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jpeds.2020.09.005","article-title":"Mortality determinants in children with biliary atresia awaiting liver transplantation","volume":"228","author":"Ziogas","year":"2021","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib50","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/lt.23437","article-title":"Outcomes of liver transplantation for patients with Alagille syndrome: the studies of pediatric liver transplantation experience","volume":"18","author":"Kamath","year":"2012","journal-title":"Liver Transpl"},{"issue":"Suppl 1","key":"10.1016\/j.iliver.2022.08.003_bib51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/ajt.14559","article-title":"OPTN\/SRTR 2016 annual data report: liver","volume":"18","author":"Kim","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib52","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.hbpd.2020.06.012","article-title":"Optimizing biliary outcomes in living donor liver transplantation: evolution towards standardization in a high-volume center","volume":"19","author":"Lin","year":"2020","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.iliver.2022.08.003_bib53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrgastro.2017.2","article-title":"Living donor liver transplantation: eliminating the wait for death in end-stage liver disease?","volume":"14","author":"Fisher","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.iliver.2022.08.003_bib54","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1111\/ajt.13757","article-title":"Donor-specific HLA antibodies in living versus deceased donor liver transplant recipients","volume":"16","author":"Levitsky","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MOT.0000000000000610","article-title":"Living donor liver transplantation","volume":"24","author":"Goldaracena","year":"2019","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib56","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/ajt.14489","article-title":"Living donor liver transplantation for biliary atresia: an analysis of 2085 cases in the registry of the Japanese Liver Transplantation Society","volume":"18","author":"Kasahara","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib57","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00007890-200207270-00013","article-title":"Potential impact of in situ liver splitting on the number of available grafts","volume":"74","author":"Toso","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.iliver.2022.08.003_bib58","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jpeds.2017.11.015","article-title":"Fifteen-year trends in pediatric liver transplants: split, whole deceased, and living donor grafts","volume":"196","author":"Mogul","year":"2018","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/lt.25340","article-title":"Expansion of the liver donor supply through greater use of split-liver transplantation: identifying optimal recipients","volume":"25","author":"Mogul","year":"2019","journal-title":"Liver Transpl"},{"key":"10.1016\/j.iliver.2022.08.003_bib60","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijsu.2020.03.017","article-title":"Current update in domino liver transplantation","volume":"82S","author":"Marques","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib61","doi-asserted-by":"crossref","DOI":"10.1111\/petr.12993","article-title":"The first case of domino-split-liver transplantation in maple syrup urine disease","volume":"21","author":"Herden","year":"2017","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib62","doi-asserted-by":"crossref","DOI":"10.1111\/petr.14174","article-title":"Surgical technique and the long-term outcomes of pediatric living donor domino liver transplantation from patients with maple syrup urine disease","volume":"26","author":"Shimizu","year":"2022","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib63","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MPG.0000000000000909","article-title":"Effectiveness of enteral versus oral nutrition with a medium-chain triglyceride formula to prevent malnutrition and growth impairment in infants with biliary atresia","volume":"62","author":"Mac\u00edas-Rosales","year":"2016","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib64","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/MPG.0000000000001958","article-title":"Systematic review: the epidemiology, natural history, and burden of Alagille syndrome","volume":"67","author":"Kamath","year":"2018","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib65","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/10892532211008742","article-title":"Combined liver kidney transplant in adult patient with Alagille syndrome and pulmonary hypertension","volume":"25","author":"McGahan","year":"2021","journal-title":"Semin CardioThorac Vasc Anesth"},{"key":"10.1016\/j.iliver.2022.08.003_bib66","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3748\/wjg.v24.i35.3980","article-title":"Pediatric hepatocellular carcinoma","volume":"24","author":"Khanna","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.iliver.2022.08.003_bib67","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/lt.26339","article-title":"Malnutrition in biliary atresia: assessment, management, and outcomes","volume":"28","author":"Boster","year":"2022","journal-title":"Liver Transpl"},{"key":"10.1016\/j.iliver.2022.08.003_bib68","series-title":"Liver disease in children","year":"2014"},{"key":"10.1016\/j.iliver.2022.08.003_bib69","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41575-019-0132-z","article-title":"Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics","volume":"16","author":"Feldman","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.iliver.2022.08.003_bib70","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jpeds.2013.06.039","article-title":"Long-term linear growth and puberty in pediatric liver transplant recipients","volume":"163","author":"Mohammad","year":"2013","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib71","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cld.2018.06.001","article-title":"Alagille syndrome","volume":"22","author":"Mitchell","year":"2018","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.iliver.2022.08.003_bib72","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/MPG.0000000000003337","article-title":"Neurodevelopmental outcomes in children with inherited liver disease and native liver","volume":"74","author":"Leung","year":"2022","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.iliver.2022.08.003_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.697581","article-title":"Sequential treatment of biliary atresia with kasai hepatoportoenterostomy and liver transplantation: benefits, risks, and outcome in 393 children","volume":"9","author":"Tambucci","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib74","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/hep.31653","article-title":"Organoids and spheroids as models for studying cholestatic liver injury and cholangiocarcinoma","volume":"74","author":"Sato","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib75","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/hep.31772","article-title":"Hepatobiliary organoids and their applications for studies of liver health and disease: are we there yet?","volume":"74","author":"Shiota","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib76","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.iliver.2022.08.003_bib77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.32107","article-title":"Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia","volume":"75","author":"Amarachintha","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib78","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.31252","article-title":"Regional differences in human biliary tissues and corresponding in vitro-derived organoids","volume":"73","author":"Rimland","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib79","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.abg3179","article-title":"Emerging cell therapy for biliary diseases","volume":"371","author":"Kurial","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.iliver.2022.08.003_bib80","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.iliver.2022.08.003_bib81","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.4360","article-title":"Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids","volume":"23","author":"Sampaziotis","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.iliver.2022.08.003_bib82","article-title":"Directing cholangiocyte morphogenesis in natural biomaterial scaffolds","volume":"9","author":"Smith","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.iliver.2022.08.003_bib83","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41586-018-0075-5","article-title":"De novo formation of the biliary system by TGF\u03b2-mediated hepatocyte transdifferentiation","volume":"557","author":"Schaub","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.iliver.2022.08.003_bib84","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.aaz6964","article-title":"Cholangiocyte organoids can repair bile ducts after transplantation in the human liver","volume":"371","author":"Sampaziotis","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.iliver.2022.08.003_bib85","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000353215","article-title":"Bone marrow mononuclear cell transplantation increases metalloproteinase-9 and 13 and decreases tissue inhibitors of metalloproteinase-1 and 2 expression in the liver of cholestatic rats","volume":"198","author":"Nunes de Carvalho","year":"2013","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.iliver.2022.08.003_bib86","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1038\/emm.2014.49","article-title":"Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis","volume":"46","author":"Kim","year":"2014","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.iliver.2022.08.003_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187970","article-title":"Cytokines, hepatic cell profiling and cell interactions during bone marrow cell therapy for liver fibrosis in cholestatic mice","volume":"12","author":"Pinheiro","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.iliver.2022.08.003_bib88","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3350\/cmh.2020.0194","article-title":"The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future","volume":"27","author":"Watanabe","year":"2021","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.iliver.2022.08.003_bib89","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13287-022-02762-x","article-title":"Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia","volume":"13","author":"Nguyen","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.iliver.2022.08.003_bib90","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/hep.24807","article-title":"Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells","volume":"55","author":"Brindley","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.iliver.2022.08.003_bib91","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/MOT.0b013e32832ce88e","article-title":"The T helper 17-regulatory T cell axis in transplant rejection and tolerance","volume":"14","author":"Mitchell","year":"2009","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.iliver.2022.08.003_bib92","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.3390\/ijms19030730","article-title":"The balance of Th17 versus Treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.iliver.2022.08.003_bib93","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.535012","article-title":"Clinical and basic research progress on treg-induced immune tolerance in liver transplantation","volume":"12","author":"Ni","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2022.08.003_bib94","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/CIRCULATIONAHA.119.040563","article-title":"Notch-1 inhibition promotes immune regulation in transplantation via treg-dependent mechanisms","volume":"140","author":"Magee","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.iliver.2022.08.003_bib95","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.sempedsurg.2012.05.003","article-title":"Biliary atresia: cellular dynamics and immune dysregulation","volume":"21","author":"Feldman","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.iliver.2022.08.003_bib96","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12519-018-0203-1","article-title":"Liver fibrosis in biliary atresia","volume":"15","author":"Shen","year":"2019","journal-title":"World J Pediatr"},{"key":"10.1016\/j.iliver.2022.08.003_bib97","unstructured":"CD4+T Cell Subset Profiling in Biliary Atresia Reveals ICOS\u2212 Regulatory T Cells as a Favorable Prognostic Factor - PMC n.d. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6637302\/(accessed July 15, 2022)."},{"key":"10.1016\/j.iliver.2022.08.003_bib98","doi-asserted-by":"crossref","DOI":"10.1097\/TP.0000000000003488","article-title":"Ischemia-reperfusion injury in allogeneic liver transplantation: a role of CD4 T cells in early allograft injury","volume":"105","author":"Kageyama","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.iliver.2022.08.003_bib99","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cell.2020.10.048","article-title":"Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia","volume":"183","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.iliver.2022.08.003_bib100","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/s41423-019-0318-x","article-title":"Jagged 1-mediated myeloid Notch 1 signaling activates HSF1\/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury","volume":"17","author":"Jin","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.iliver.2022.08.003_bib101","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/08916934.2019.1637424","article-title":"Blockade of the Notch 1\/Jagged 1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice","volume":"52","author":"Bai","year":"2019","journal-title":"Autoimmunity"},{"key":"10.1016\/j.iliver.2022.08.003_bib102","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.clinre.2015.02.003","article-title":"Immune dysregulation in Alagille syndrome: a new feature of the evolving phenotype","volume":"39","author":"Tilib Shamoun","year":"2015","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.iliver.2022.08.003_bib103","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fimmu.2020.00735","article-title":"CD28 signaling drives notch ligand expression on CD4 T cells","volume":"11","author":"Mitra","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2022.08.003_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.609324","article-title":"Notch signaling in B cell immune responses","volume":"11","author":"Garis","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2022.08.003_bib105","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0140-6736(21)01256-3","article-title":"Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study","volume":"398","author":"Gonzales","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.iliver.2022.08.003_bib106","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13116","article-title":"Single-cell profiling reveals distinct immune phenotypes that contribute to ischaemia-reperfusion injury after steatotic liver transplantation","volume":"54","author":"Yang","year":"2021","journal-title":"Cell Prolif"}],"container-title":["iLIVER"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772947822000421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772947822000421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:25:02Z","timestamp":1778934302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772947822000421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":106,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2772947822000421"],"URL":"https:\/\/doi.org\/10.1016\/j.iliver.2022.08.003","relation":{},"ISSN":["2772-9478"],"issn-type":[{"value":"2772-9478","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced therapies for congenital biliary tract malformation: From bench to bedside","name":"articletitle","label":"Article Title"},{"value":"iLIVER","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iliver.2022.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press.","name":"copyright","label":"Copyright"}]}}