{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:04:12Z","timestamp":1793120652933,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iLIVER"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.iliver.2026.100222","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:53:06Z","timestamp":1770227586000},"page":"100222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biological aging across the metabolic dysfunction\u2013associated steatotic liver disease spectrum: A systematic review"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-8478","authenticated-orcid":false,"given":"Chukwuemeka E.","family":"Ogbu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella C.","family":"Ogbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidera P.","family":"Ogbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinazor","family":"Umerah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.iliver.2026.100222_bib1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"issue":"Suppl","key":"10.1016\/j.iliver.2026.100222_bib2","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2025","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.54707","article-title":"Estimated burden of metabolic dysfunction-associated steatotic liver disease in US adults, 2020 to 2050","volume":"8","author":"Le","year":"2025","journal-title":"JAMA Netw Open"},{"issue":"11","key":"10.1016\/j.iliver.2026.100222_bib4","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/s41591-023-02603-1","article-title":"Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.iliver.2026.100222_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib6","first-page":"16","article-title":"Age as a modifiable risk factor for chronic disease","volume":"17","author":"Bland","year":"2018","journal-title":"Integr Med"},{"issue":"3","key":"10.1016\/j.iliver.2026.100222_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.mad.2005.10.004","article-title":"A new approach to the concept and computation of biological age","volume":"127","author":"Klemera","year":"2006","journal-title":"Mech Ageing Dev"},{"issue":"12","key":"10.1016\/j.iliver.2026.100222_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002718","article-title":"A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study","volume":"15","author":"Liu","year":"2018","journal-title":"PLoS Med"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging"},{"issue":"10","key":"10.1016\/j.iliver.2026.100222_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"issue":"2","key":"10.1016\/j.iliver.2026.100222_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.iliver.2026.100222_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73420","article-title":"DunedinPACE, a DNA methylation biomarker of the pace of aging","volume":"11","author":"Belsky","year":"2022","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10238-025-01608-z","article-title":"The relationship between telomere length and aging-related diseases","volume":"25","author":"Huang","year":"2025","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.iliver.2026.100222_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.iliver.2026.100222_bib15","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J Clin Investig"},{"issue":"10","key":"10.1016\/j.iliver.2026.100222_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.iliver.2026.100222_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101251","article-title":"Senescent cells as promising targets to tackle age-related diseases","volume":"66","author":"Pra\u0161nikar","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/hep.30834","article-title":"The role of senescence in the development of nonalcoholic fatty liver disease and progression to nonalcoholic steatohepatitis","volume":"71","author":"Papatheodoridi","year":"2020","journal-title":"Hepatology"},{"issue":"43","key":"10.1016\/j.iliver.2026.100222_bib19","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1073\/pnas.1412759111","article-title":"Obesity accelerates epigenetic aging of human liver","volume":"111","author":"Horvath","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib20","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1186\/s12889-024-20808-y","article-title":"Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study","volume":"24","author":"Tong","year":"2024","journal-title":"BMC Public Health"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s12916-023-03136-7","article-title":"The association between telomere length and non-alcoholic fatty liver disease: a prospective study","volume":"21","author":"Tang","year":"2023","journal-title":"BMC Med"},{"issue":"2","key":"10.1016\/j.iliver.2026.100222_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96685","article-title":"DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis","volume":"3","author":"Loomba","year":"2018","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib23","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s11357-023-00903-5","article-title":"DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease","volume":"46","author":"Xia","year":"2024","journal-title":"GeroScience"},{"issue":"10","key":"10.1016\/j.iliver.2026.100222_bib24","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/nu17101618","article-title":"Accelerated biological aging, genetic susceptibility, and non-alcoholic fatty liver disease: two prospective cohort studies","volume":"17","author":"Zhao","year":"2025","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib25","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.14336\/AD.2022.0318","article-title":"Non-alcoholic fatty liver disease and liver fibrosis during aging","volume":"13","author":"Li","year":"2022","journal-title":"Aging Dis"},{"issue":"6","key":"10.1016\/j.iliver.2026.100222_bib26","first-page":"1220","article-title":"Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: do they measure the same thing?","volume":"187","author":"Belsky","year":"2018","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.iliver.2026.100222_bib27","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.iliver.2026.100222_bib28","series-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in meta-analyses [Webpage on the Internet]","author":"Wells","year":"2011"},{"issue":"3","key":"10.1016\/j.iliver.2026.100222_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/XEB.0000000000000064","article-title":"Conducting systematic reviews of association (etiology): the Joanna Briggs Institute's approach","volume":"13","author":"Moola","year":"2015","journal-title":"Int J Evid Base Healthc"},{"key":"10.1016\/j.iliver.2026.100222_bib30","article-title":"Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline","volume":"l6890","author":"Campbell","year":"2020","journal-title":"Br Med J"},{"issue":"2","key":"10.1016\/j.iliver.2026.100222_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2024.101579","article-title":"Biological aging accelerates hepatic fibrosis: insights from the NHANES 2017\u20132020 and genome-wide association study analysis","volume":"30","author":"Zhao","year":"2025","journal-title":"Ann Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib32","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s12876-025-03955-3","article-title":"Association of biological aging and the prevalence of nonalcoholic fatty liver disease: a population-based study","volume":"25","author":"Liu","year":"2025","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12876-025-03752-y","article-title":"Biological age prediction and NAFLD risk assessment: a machine learning model based on a multicenter population in Nanchang, Jiangxi, China","volume":"25","author":"Deng","year":"2025","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.iliver.2026.100222_bib34","article-title":"Associations of accelerated biological ageing, genetic predisposition, and life expectancy with non-alcoholic fatty liver disease and cirrhosis: a prospective cohort study [preprint]","author":"Guo","year":"2024","journal-title":"SSRN"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41043-025-00755-z","article-title":"The effect of healthy eating index-2015 in the associations of biological aging and non-alcoholic fatty liver disease: an interaction and mediation analysis","volume":"44","author":"Zhang","year":"2025","journal-title":"J Health Popul Nutr"},{"key":"10.1016\/j.iliver.2026.100222_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118455","article-title":"Biological ageing mediates the associations between urinary metals and metabolic dysfunction-associated steatotic liver disease","volume":"300","author":"Wu","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.iliver.2026.100222_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/aje\/kwaf046","article-title":"Combined effect of biological age and fine particulate matter pollution with risk of non-alcoholic fatty liver disease in the UK biobank: a prospective cohort study","author":"Zhang","year":"2025","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.iliver.2026.100222_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2024.105477","article-title":"Association between biological aging and the risk of mortality in individuals with non-alcoholic fatty liver disease: a prospective cohort study","volume":"124","author":"Wang","year":"2024","journal-title":"Arch Gerontol Geriatr"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib39","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3350\/cmh.2024.0691","article-title":"Leukocyte telomere shortening in metabolic dysfunction-associated steatotic liver disease and all-cause\/cause-specific mortality","volume":"30","author":"Kim","year":"2024","journal-title":"Clin Mol Hepatol"},{"issue":"25","key":"10.1016\/j.iliver.2026.100222_bib40","article-title":"Biological age, PNPLA3, and risk of metabolic dysfunction-associated steatotic liver disease","volume":"S1542-S3565","author":"Gawrieh","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.iliver.2026.100222_bib41","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/jdi.12555","article-title":"Deoxyribonucleic acid telomere length shortening can predict the incidence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus","volume":"8","author":"Ping","year":"2017","journal-title":"J Diabetes Investig"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12889-025-21322-5","article-title":"BMI trajectories are associated with NAFLD and advanced fibrosis via aging-inflammation mediation","volume":"25","author":"Peng","year":"2025","journal-title":"BMC Public Health"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13148-025-01945-6","article-title":"Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration","volume":"17","author":"Van Dijck","year":"2025","journal-title":"Clin Epigenet"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2024.101602","article-title":"Phthalates exposure, biological aging, and increased risks of insulin resistance, prediabetes, and diabetes in adults with metabolic dysfunction-associated steatotic liver disease","volume":"51","author":"Yang","year":"2025","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.iliver.2026.100222_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101833","article-title":"Emerging role of aging in the progression of NAFLD to HCC","volume":"84","author":"He","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"8","key":"10.1016\/j.iliver.2026.100222_bib46","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/biom12081079","article-title":"Progress in nonalcoholic fatty liver disease: SIRT family regulates mitochondrial biogenesis","volume":"12","author":"Zeng","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.iliver.2026.100222_bib47","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.1038\/s41598-023-34710-x","article-title":"Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis","volume":"13","author":"Undamatla","year":"2023","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.iliver.2026.100222_bib48","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/jgh.16272","article-title":"AMPK\/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression","volume":"38","author":"Marcondes-de-Castro","year":"2023","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s44324-024-00022-5","article-title":"Autophagy and hepatic lipid metabolism: mechanistic insight and therapeutic potential for MASLD","volume":"2","author":"Raza","year":"2024","journal-title":"NPJ Metab Health Dis"},{"issue":"3","key":"10.1016\/j.iliver.2026.100222_bib50","doi-asserted-by":"crossref","first-page":"G554","DOI":"10.1152\/ajpgi.00223.2019","article-title":"Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy","volume":"318","author":"Chiang","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"10.1016\/j.iliver.2026.100222_bib51","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11605-021-05188-7","article-title":"The role of gut-derived lipopolysaccharides and the intestinal barrier in fatty liver diseases","volume":"26","author":"An","year":"2022","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"10.1016\/j.iliver.2026.100222_bib52","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s43587-023-00432-y","article-title":"Author Correction: effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial","volume":"3","author":"Waziry","year":"2023","journal-title":"Nat Aging"},{"issue":"2","key":"10.1016\/j.iliver.2026.100222_bib53","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11357-019-00149-0","article-title":"One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project","volume":"42","author":"Gensous","year":"2020","journal-title":"GeroScience"},{"issue":"26","key":"10.1016\/j.iliver.2026.100222_bib54","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1056\/NEJMra1905136","article-title":"Effects of intermittent fasting on health, aging, and disease","volume":"381","author":"de Cabo","year":"2019","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.iliver.2026.100222_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100084","article-title":"The effects of the Mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial","volume":"9","author":"Casas","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.iliver.2026.100222_bib56","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/liv.15264","article-title":"Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: the MEDINA randomised controlled trial","volume":"42","author":"George","year":"2022","journal-title":"Liver Int"},{"issue":"3","key":"10.1016\/j.iliver.2026.100222_bib57","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL\u2013EASD\u2013EASO Clinical Practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.iliver.2026.100222_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1504830","article-title":"Association of blood cadmium levels with epigenetic age acceleration in U.S. adults aged > 50 years","volume":"13","author":"Mi","year":"2025","journal-title":"Front Public Health"},{"issue":"46","key":"10.1016\/j.iliver.2026.100222_bib59","doi-asserted-by":"crossref","first-page":"74510","DOI":"10.18632\/oncotarget.12903","article-title":"Long-term exposure to air pollution is associated with biological aging","volume":"7","author":"Ward-Caviness","year":"2016","journal-title":"Oncotarget"},{"issue":"20","key":"10.1016\/j.iliver.2026.100222_bib60","doi-asserted-by":"crossref","first-page":"14690","DOI":"10.1021\/acs.est.2c05534","article-title":"Short-term exposure of PM2.5 and epigenetic aging: a quasi-experimental study","volume":"56","author":"Gao","year":"2022","journal-title":"Environ Sci Technol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib61","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2012.08.009","article-title":"Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model","volume":"58","author":"Zheng","year":"2013","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.iliver.2026.100222_bib62","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.32324","article-title":"Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD","volume":"76","author":"Moore","year":"2022","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.iliver.2026.100222_bib63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmet.2013.07.004","article-title":"DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery","volume":"18","author":"Ahrens","year":"2013","journal-title":"Cell Metab"},{"issue":"22","key":"10.1016\/j.iliver.2026.100222_bib64","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.18632\/aging.206184","article-title":"Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution","volume":"16","author":"Tong","year":"2024","journal-title":"Aging"},{"issue":"5","key":"10.1016\/j.iliver.2026.100222_bib65","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jamaoncol.2016.5945","article-title":"Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study","volume":"3","author":"Haycock","year":"2017","journal-title":"JAMA Oncol"},{"issue":"5","key":"10.1016\/j.iliver.2026.100222_bib66","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD Practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease","volume":"77","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib67","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1186\/s12967-023-04495-8","article-title":"Association betweenlife's essential 8 andbiological ageing amongUS adults","volume":"21","author":"Zhang","year":"2023","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13148-019-0790-2","article-title":"The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely Obese patients","volume":"12","author":"Fraszczyk","year":"2020","journal-title":"Clin Epigenet"},{"issue":"10","key":"10.1016\/j.iliver.2026.100222_bib69","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13439","article-title":"DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study","volume":"20","author":"Fiorito","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.iliver.2026.100222_bib70","article-title":"FDA approves first treatment for patients with liver scarring due to fatty liver disease (Rezdiffra [resmetirom])","year":"2024","journal-title":"News release"},{"issue":"9","key":"10.1016\/j.iliver.2026.100222_bib71","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13934","article-title":"The lipidomic correlates of epigenetic aging across the adult lifespan: a population-based study","volume":"22","author":"Liu","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib72","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12920-024-01914-7","article-title":"Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults","volume":"17","author":"Lin","year":"2024","journal-title":"BMC Med Genom"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2401943","article-title":"Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis","volume":"391","author":"Loomba","year":"2024","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.iliver.2026.100222_bib74","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMoa2028395","article-title":"A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis","volume":"384","author":"Newsome","year":"2021","journal-title":"N Engl J Med"},{"issue":"21","key":"10.1016\/j.iliver.2026.100222_bib75","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMoa2413258","article-title":"Phase 3 trial of semaglutide in metabolic dysfunction-associated steatohepatitis","volume":"392","author":"Sanyal","year":"2025","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib76","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbrc.2016.05.086","article-title":"GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK\/mTOR pathway","volume":"476","author":"He","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"10.1016\/j.iliver.2026.100222_bib77","doi-asserted-by":"crossref","first-page":"14514","DOI":"10.3390\/cimb46120872","article-title":"Spotlight on the mechanism of action of semaglutide","volume":"46","author":"Papakonstantinou","year":"2024","journal-title":"Curr Issues Mol Biol"},{"issue":"9","key":"10.1016\/j.iliver.2026.100222_bib78","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1038\/s41591-025-03799-0","article-title":"Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis","volume":"31","author":"Jara","year":"2025","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.iliver.2026.100222_bib79","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.iliver.2026.100222_bib80","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/diseases12120317","article-title":"Dasatinib and quercetin as senolytic drugs improve fat deposition and exhibit antifibrotic effects in the medaka metabolic dysfunction-associated steatotic liver disease model","volume":"12","author":"Yakubo","year":"2024","journal-title":"Diseases"},{"key":"10.1016\/j.iliver.2026.100222_bib81","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.iliver.2026.100222_bib82","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.iliver.2026.100222_bib83","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41392-024-02104-8","article-title":"Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics","volume":"10","author":"Ma","year":"2025","journal-title":"Signal Transduct Targeted Ther"},{"issue":"1","key":"10.1016\/j.iliver.2026.100222_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.iliver.2026.100222_bib85","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41387-021-00170-3","article-title":"Growth differentiation factor-15 and the association between type 2 diabetes and liver fibrosis in NAFLD","volume":"11","author":"Bilson","year":"2021","journal-title":"Nutr Diabetes"},{"issue":"7","key":"10.1016\/j.iliver.2026.100222_bib86","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41575-024-00913-4","article-title":"Cell senescence in liver diseases: pathological mechanism and theranostic opportunity","volume":"21","author":"Sanfeliu-Redondo","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"}],"container-title":["iLIVER"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277294782600006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277294782600006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:03:30Z","timestamp":1773943410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277294782600006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S277294782600006X"],"URL":"https:\/\/doi.org\/10.1016\/j.iliver.2026.100222","relation":{},"ISSN":["2772-9478"],"issn-type":[{"value":"2772-9478","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological aging across the metabolic dysfunction\u2013associated steatotic liver disease spectrum: A systematic review","name":"articletitle","label":"Article Title"},{"value":"iLIVER","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iliver.2026.100222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press.","name":"copyright","label":"Copyright"}],"article-number":"100222"}}