{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:55:27Z","timestamp":1793850927446,"version":"4.6.1"},"reference-count":126,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108012"],"award-info":[{"award-number":["82120108012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930086"],"award-info":[{"award-number":["81930086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400691"],"award-info":[{"award-number":["82400691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010816","name":"Anhui Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["202204295107020008"],"award-info":[{"award-number":["202204295107020008"]}],"id":[{"id":"10.13039\/501100010816","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2022AH010070"],"award-info":[{"award-number":["2022AH010070"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2025AHGXZK40772"],"award-info":[{"award-number":["2025AHGXZK40772"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772312"],"award-info":[{"award-number":["2025M772312"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iLIVER"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.iliver.2026.100234","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:59:57Z","timestamp":1776409197000},"page":"100234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heterogeneity of hepatic macrophages in MASLD\/MASH: Lipid-associated programs, molecular mechanisms, spatial niches, and therapeutic implications"],"prefix":"10.1016","volume":"5","author":[{"given":"Kaipeng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beicheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anliang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41575-024-00967-4","article-title":"Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions","volume":"21","author":"Mak","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"Suppl","key":"10.1016\/j.iliver.2026.100234_bib2","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2025","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s13679-025-00637-9","article-title":"Metabolically healthy obesity and metabolic dysfunction-associated steatotic liver disease (MASLD): navigating the controversies in disease development and progression","volume":"14","author":"Koliaki","year":"2025","journal-title":"Curr Obes Rep"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41573-024-01084-2","article-title":"Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)","volume":"24","author":"Do","year":"2025","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"10.1016\/j.iliver.2026.100234_bib5","article-title":"Understanding the complex macrophage landscape in MASLD","volume":"6","author":"De Ponti","year":"2024","journal-title":"JHEP Rep"},{"issue":"8","key":"10.1016\/j.iliver.2026.100234_bib6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41574-022-00675-6","article-title":"Macrophage functional diversity in NAFLD\u2014More than inflammation","volume":"18","author":"Barreby","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s43556-022-00088-x","article-title":"Mesenchymal stem cells-based therapy in liver diseases","volume":"3","author":"Han","year":"2022","journal-title":"Mol Biomed"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib8","doi-asserted-by":"crossref","first-page":"sxaf072","DOI":"10.1093\/stmcls\/sxaf072","article-title":"Macrophage heterogeneity and plasticity in liver injury and repair mechanisms","volume":"44","author":"Zhang","year":"2026","journal-title":"Stem Cell"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"11","key":"10.1016\/j.iliver.2026.100234_bib10","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.tem.2024.04.009","article-title":"Lipid-associated macrophages between aggravation and alleviation of metabolic diseases","volume":"35","author":"Xu","year":"2024","journal-title":"Trends Endocrinol Metabol"},{"issue":"4","key":"10.1016\/j.iliver.2026.100234_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5483\/BMBRep.2022.55.4.022","article-title":"Roles of heterogenous hepatic macrophages in the progression of liver diseases","volume":"55","author":"Lee","year":"2022","journal-title":"BMB Rep"},{"key":"10.1016\/j.iliver.2026.100234_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.690813","article-title":"Hepatic macrophage responses in inflammation, a function of plasticity, heterogeneity or both?","volume":"12","author":"Zwicker","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.iliver.2026.100234_bib13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrinol Metabol"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2213-8587(24)00318-8","article-title":"Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment","volume":"13","author":"Stefan","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3390\/livers4030033","article-title":"Understanding macrophage complexity in metabolic dysfunction-associated steatotic liver disease: transitioning from the M1\/M2 paradigm to spatial dynamics","volume":"4","author":"Ahamed","year":"2024","journal-title":"Liver"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated mechanisms of MASLD pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis"},{"issue":"S1","key":"10.1016\/j.iliver.2026.100234_bib17","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/apt.17930","article-title":"Pathogenesis of MASLD and MASH\u2013role of insulin resistance and lipotoxicity","volume":"59","author":"Bansal","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12964-025-02562-9","article-title":"The heterogeneity of monocyte-derived macrophages in MASH pathogenesis","volume":"24","author":"Zhang","year":"2025","journal-title":"Cell Commun Signal"},{"issue":"5","key":"10.1016\/j.iliver.2026.100234_bib19","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cmet.2024.04.006","article-title":"Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease","volume":"36","author":"Bo","year":"2024","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.iliver.2026.100234_bib20","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jhep.2023.08.030","article-title":"Endocrine aspects of metabolic dysfunction-associated steatotic liver disease (MASLD): beyond insulin resistance","volume":"79","author":"Hutchison","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.iliver.2026.100234_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107990","article-title":"The role of glycolysis in MASLD development: pathogenesis and therapeutic strategies","volume":"221","author":"Shang","year":"2025","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib22","doi-asserted-by":"crossref","first-page":"9522","DOI":"10.1038\/s41467-024-53733-0","article-title":"PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity","volume":"15","author":"Gilglioni","year":"2024","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101485","article-title":"Therapeutic potential of STE20-type kinase STK25 inhibition for the prevention and treatment of metabolically induced hepatocellular carcinoma","volume":"19","author":"Xia","year":"2025","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-025-02370-2","article-title":"Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC","volume":"24","author":"Huang","year":"2025","journal-title":"Mol Cancer"},{"issue":"5","key":"10.1016\/j.iliver.2026.100234_bib25","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3390\/ijms26051877","article-title":"Aspirin eugenol ester alleviates energy metabolism disorders by reducing oxidative damage and inflammation in the livers of broilers under high-stocking-density stress","volume":"26","author":"Guo","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib26","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1038\/s41598-025-88538-8","article-title":"Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1\/c-Myc\/MCT-1 pathway to induce liver fibrosis","volume":"15","author":"Huang","year":"2025","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tips.2024.05.004","article-title":"Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment","volume":"45","author":"Booijink","year":"2024","journal-title":"Trends Pharmacol Sci"},{"issue":"8","key":"10.1016\/j.iliver.2026.100234_bib28","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.cmet.2024.05.008","article-title":"Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH","volume":"36","author":"Zhang","year":"2024","journal-title":"Cell Metab"},{"issue":"764","key":"10.1016\/j.iliver.2026.100234_bib29","doi-asserted-by":"crossref","first-page":"eadi0284","DOI":"10.1126\/scitranslmed.adi0284","article-title":"HIF-2\u03b1 drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis","volume":"16","author":"Jeelani","year":"2024","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.iliver.2026.100234_bib30","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J Hepatol"},{"issue":"10","key":"10.1016\/j.iliver.2026.100234_bib31","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.immuni.2024.08.016","article-title":"Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease","volume":"57","author":"Guo","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.iliver.2026.100234_bib32","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3389\/fimmu.2019.03112","article-title":"Macrophage phenotype and function in liver disorder","volume":"10","author":"Dou","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2026.100234_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1199519","article-title":"Activation of Kupffer cells in NAFLD and NASH: mechanisms and therapeutic interventions","volume":"11","author":"Xu","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"10.1016\/j.iliver.2026.100234_bib34","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41423-025-01298-3","article-title":"Liver macrophages: development, dynamics, and functions","volume":"22","author":"Nusse","year":"2025","journal-title":"Cell Mol Immunol"},{"issue":"8","key":"10.1016\/j.iliver.2026.100234_bib35","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.3390\/molecules26082231","article-title":"F4\/80+ kupffer cell-derived oncostatin M sustains the progression phase of liver regeneration through inhibition of TGF-\u03b22 pathway","volume":"26","author":"Lu","year":"2021","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.iliver.2026.100234_bib36","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/CIRCRESAHA.123.322136","article-title":"Lessons of vascular specialization from secondary lymphoid organ lymphatic endothelial cells","volume":"132","author":"Arroz-Madeira","year":"2023","journal-title":"Circ Res"},{"issue":"9","key":"10.1016\/j.iliver.2026.100234_bib37","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/j.immuni.2021.08.006","article-title":"A subset of Kupffer cells regulates metabolism through the expression of CD36","volume":"54","author":"Bl\u00e9riot","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.iliver.2026.100234_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5479013","article-title":"Monocyte-derived macrophages are impaired in myelodysplastic syndrome","volume":"2016","author":"Han","year":"2016","journal-title":"J Immunol Res"},{"issue":"10","key":"10.1016\/j.iliver.2026.100234_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113164","article-title":"Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib40","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41577-021-00639-3","article-title":"Immune cell-mediated features of non-alcoholic steatohepatitis","volume":"22","author":"Huby","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.iliver.2026.100234_bib41","article-title":"microRNA: role in macrophage polarization and the pathogenesis of the liver fibrosis","volume":"14","author":"Yu","year":"2023","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.iliver.2026.100234_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.378","article-title":"Single-cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosis","volume":"4","author":"Cheng","year":"2023","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib43","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/s41467-025-58360-x","article-title":"Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis","volume":"16","author":"Pessenda","year":"2025","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib44","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1038\/s41598-017-08121-8","article-title":"Classification of M1\/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis","volume":"7","author":"Bertani","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0265196","article-title":"Effect of stimulation time on the expression of human macrophage polarization markers","volume":"17","author":"Unuvar Purcu","year":"2022","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.iliver.2026.100234_bib46","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.3390\/ijms22136995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib47","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s12276-025-01408-1","article-title":"A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis","volume":"57","author":"Park","year":"2025","journal-title":"Exp Mol Med"},{"issue":"6","key":"10.1016\/j.iliver.2026.100234_bib48","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jcmgh.2023.03.002","article-title":"The multifaceted roles of macrophages in NAFLD pathogenesis","volume":"15","author":"Vonderlin","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib49","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2017.07.018","article-title":"A liver capsular network of monocyte-derived macrophages restricts hepatic dissemination of intraperitoneal bacteria by neutrophil recruitment","volume":"47","author":"Sierro","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.iliver.2026.100234_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.ircmb.2022.04.006","article-title":"Macrophages as key regulators of liver health and disease","volume":"368","author":"Papachristoforou","year":"2022","journal-title":"Int Rev Cell Mol Biol"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib51","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/livers3020016","article-title":"Peritoneal immunity in liver disease","volume":"3","author":"Delo","year":"2023","journal-title":"Liver"},{"key":"10.1016\/j.iliver.2026.100234_bib52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fimmu.2015.00225","article-title":"Revisiting mouse peritoneal macrophages: heterogeneity, development, and function","volume":"6","author":"Cassado","year":"2015","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib53","first-page":"94","article-title":"Rediscovering peritoneal macrophages in a murine endometriosis model","volume":"32","author":"Yuan","year":"2017","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100511","article-title":"Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH","volume":"2","author":"Daemen","year":"2021","journal-title":"STAR Protoc"},{"issue":"18","key":"10.1016\/j.iliver.2026.100234_bib55","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1158\/0008-5472.CAN-22-1427","article-title":"Lipid-associated macrophages are induced by cancer-associated fibroblasts and mediate immune suppression in breast cancer","volume":"82","author":"Timperi","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.iliver.2026.100234_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3353250","article-title":"The contribution of hepatic macrophage heterogeneity during liver regeneration after partial hepatectomy in mice","volume":"2022","author":"Ma","year":"2022","journal-title":"J Immunol Res"},{"issue":"35","key":"10.1016\/j.iliver.2026.100234_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2405746121","article-title":"Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2","volume":"121","author":"Ganguly","year":"2024","journal-title":"Proc Natl Acad Sc U S A"},{"key":"10.1016\/j.iliver.2026.100234_bib58","article-title":"TREM2 in MASH: integrating lipid metabolism and immune response","volume":"16","author":"Shi","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2026.100234_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1494250","article-title":"The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies","volume":"15","author":"Ma","year":"2024","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.iliver.2026.100234_bib60","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.immuni.2022.08.002","article-title":"Liver macrophages in health and disease","volume":"55","author":"Guilliams","year":"2022","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.iliver.2026.100234_bib61","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41588-024-01687-w","article-title":"A spatiotemporal atlas of cholestatic injury and repair in mice","volume":"56","author":"Wu","year":"2024","journal-title":"Nat Genet"},{"key":"10.1016\/j.iliver.2026.100234_bib62","article-title":"Epigenetic regulation of kupffer cell function in health and disease","volume":"11","author":"Bennett","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2026.100234_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1195699","article-title":"Macrophages and the development and progression of non-alcoholic fatty liver disease","volume":"14","author":"Alabdulaali","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2026.100234_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1150118","article-title":"Major roles of kupffer cells and macrophages in NAFLD development","volume":"14","author":"Park","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.iliver.2026.100234_bib65","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2119\/molmed.2016.00033","article-title":"Activation of proteinase 3 contributes to non-alcoholic Fatty Liver disease (NAFLD) and insulin resistance","volume":"22","author":"Toonen","year":"2016","journal-title":"Mol Med"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib66","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.immuni.2020.08.004","article-title":"Osteopontin expression identifies a subset of recruited macrophages distinct from kupffer cells in the fatty liver","volume":"53","author":"Remmerie","year":"2020","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.iliver.2026.100234_bib67","article-title":"C\/EBP\u03b2-VCAM1 axis in kupffer cells promotes hepatic inflammation in MASLD","volume":"7","author":"Lin","year":"2025","journal-title":"JHEP Rep"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib68","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1038\/s41467-024-53659-7","article-title":"Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells","volume":"15","author":"Huang","year":"2024","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159524","article-title":"Kupffer cells undergo fundamental changes during the development of experimental NASH and are critical in initiating liver damage and inflammation","volume":"11","author":"Reid","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib70","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.4251\/wjgo.v16.i12.4685","article-title":"Vitamin D 1, 25-Dihydroxyvitamin D3 reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization","volume":"16","author":"Luo","year":"2024","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.iliver.2026.100234_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131236","article-title":"Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps","volume":"452","author":"Yin","year":"2023","journal-title":"J Hazard Mater"},{"issue":"10","key":"10.1016\/j.iliver.2026.100234_bib72","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.4049\/jimmunol.1400121","article-title":"CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis","volume":"192","author":"Ponichtera","year":"2014","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib73","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s11658-025-00824-5","article-title":"CD209a regulates metabolic dysfunction-associated steatotic liver disease development through macrophage STAT3 signaling pathway","volume":"30","author":"Chen","year":"2025","journal-title":"Cell Mol Biol Lett"},{"issue":"11","key":"10.1016\/j.iliver.2026.100234_bib74","article-title":"Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease","volume":"5","author":"Chan","year":"2023","journal-title":"JHEP Rep"},{"issue":"9","key":"10.1016\/j.iliver.2026.100234_bib75","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i9.110515","article-title":"Macrophage and inflammation in diabetes and metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutic strategies","volume":"16","author":"Zhang","year":"2025","journal-title":"World J Diabetes"},{"key":"10.1016\/j.iliver.2026.100234_bib76","first-page":"goae089","article-title":"Active role of the immune system in metabolic dysfunction-associated steatotic liver disease","volume":"12","author":"Mori","year":"2024","journal-title":"Gastroenterol Rep"},{"key":"10.1016\/j.iliver.2026.100234_bib77","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fimmu.2020.01169","article-title":"Crosstalk between liver macrophages and surrounding cells in nonalcoholic steatohepatitis","volume":"11","author":"Li","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.iliver.2026.100234_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708978","article-title":"Hepatic macrophage as a key player in fatty liver disease","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"issue":"21","key":"10.1016\/j.iliver.2026.100234_bib79","doi-asserted-by":"crossref","DOI":"10.1172\/JCI190635","article-title":"Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice","volume":"135","author":"Guan","year":"2025","journal-title":"J Clin Investig"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib80","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.immuni.2022.11.013","article-title":"Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib81","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000578","article-title":"Biological and clinical role of TREM2 in liver diseases","volume":"8","author":"Ma","year":"2024","journal-title":"Hepatol Commun"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib82","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib83","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.molcel.2019.07.028","article-title":"Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis","volume":"75","author":"Xiong","year":"2019","journal-title":"Mol Cell"},{"issue":"7783","key":"10.1016\/j.iliver.2026.100234_bib84","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib85","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/ame2.70053","article-title":"Therapeutic targeting of myeloid cells in liver fibrosis: mechanisms and clinical prospects","volume":"8","author":"Wang","year":"2025","journal-title":"Animal Model Exp Med"},{"key":"10.1016\/j.iliver.2026.100234_bib86","article-title":"Integrated analysis highlights the immunosuppressive role of TREM2+ macrophages in hepatocellular carcinoma","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib87","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1038\/s41467-025-60295-2","article-title":"MACanalyzeR scRNAseq analysis tool reveals PPAR\u03b3HIGH\/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT","volume":"16","author":"Ninni","year":"2025","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib88","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1038\/s41588-025-02407-8","article-title":"Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease","volume":"57","author":"Li","year":"2025","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib89","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41698-024-00752-1","article-title":"Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma","volume":"8","author":"Ye","year":"2024","journal-title":"npj Precis Oncol"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib90","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.immuni.2025.01.002","article-title":"Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair","volume":"58","author":"De Ponti","year":"2025","journal-title":"Immunity"},{"issue":"21","key":"10.1016\/j.iliver.2026.100234_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110701","article-title":"Hepatic zonation in MASLD: old question, new challenge in the era of spatial omics","volume":"26","author":"Paolini","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib92","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2023-000003","article-title":"Spatial dimension of macrophage heterogeneity in liver diseases","volume":"1","author":"Guillot","year":"2023","journal-title":"eGastroenterology"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib93","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.iliver.2026.100234_bib94","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1507\/endocrj.EJ25-0140","article-title":"Advancing liver metabolic zonation with single-cell and spatial omics","volume":"72","author":"Fujimoto","year":"2025","journal-title":"Endocr J"},{"issue":"11","key":"10.1016\/j.iliver.2026.100234_bib95","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s44161-023-00354-3","article-title":"Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis","volume":"2","author":"Patterson","year":"2023","journal-title":"Nat Cardiovasc Res"},{"issue":"738","key":"10.1016\/j.iliver.2026.100234_bib96","doi-asserted-by":"crossref","first-page":"eadk1866","DOI":"10.1126\/scitranslmed.adk1866","article-title":"Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation","volume":"16","author":"Zhou","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.iliver.2026.100234_bib97","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9980877","article-title":"Remodeling of macrophages in white adipose tissue under the conditions of obesity as well as lipolysis","volume":"2021","author":"Tong","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115310","article-title":"Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms","volume":"44","author":"Zhou","year":"2025","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.iliver.2026.100234_bib99","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4049\/jimmunol.2300847","article-title":"Cutting edge: hepatic stellate cells drive the phenotype of monocyte-derived macrophages to regulate liver fibrosis in metabolic dysfunction-associated steatohepatitis","volume":"213","author":"Chan","year":"2024","journal-title":"J Immunol"},{"issue":"10","key":"10.1016\/j.iliver.2026.100234_bib100","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41423-025-01307-5","article-title":"Immunopathogenic mechanisms and immunoregulatory therapies in MASLD","volume":"22","author":"He","year":"2025","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"10.1016\/j.iliver.2026.100234_bib101","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/HEP.0000000000001429","article-title":"MIF-mediated crosstalk between THRSP + hepatocytes and CD74 + lipid-associated macrophages in hepatic periportal zone drives MASH","volume":"83","author":"Xu","year":"2026","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib102","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1080\/15548627.2019.1580105","article-title":"The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance","volume":"15","author":"Huang","year":"2019","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib103","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.4254\/wjh.v14.i7.1365","article-title":"Regulation of PPAR-\u03b3 activity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease","volume":"14","author":"Li","year":"2022","journal-title":"World J Hepatol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib104","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41467-025-56565-8","article-title":"A mutation in LXR\u03b1 uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis","volume":"16","author":"Clark","year":"2025","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib105","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1021\/acsmedchemlett.6b00234","article-title":"Discovery of highly potent liver X receptor \u03b2 agonists","volume":"7","author":"Kick","year":"2016","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.iliver.2026.100234_bib106","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08009","article-title":"LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling","volume":"4","author":"Ito","year":"2015","journal-title":"eLife"},{"issue":"20","key":"10.1016\/j.iliver.2026.100234_bib107","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.3390\/ijms20205045","article-title":"Liver X receptors regulate cholesterol metabolism and immunity in hepatic nonparenchymal cells","volume":"20","author":"Endo-Umeda","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.iliver.2026.100234_bib108","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1444198","article-title":"Targeting hepatic macrophages for non-alcoholic fatty liver disease therapy","volume":"12","author":"Tian","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"10.1016\/j.iliver.2026.100234_bib109","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5625\/lar.2018.34.4.133","article-title":"The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"34","author":"Cha","year":"2018","journal-title":"Lab Anim Res"},{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib110","article-title":"Molecular imaging of macrophage composition and dynamics in MASLD","volume":"6","author":"Yang","year":"2024","journal-title":"JHEP Rep"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib111","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5114\/ceh.2024.139983","article-title":"Liver macrophage activation: relation with hepatic histopathological changes in patients with metabolic associated steatotic liver disease","volume":"10","author":"Hegazy","year":"2024","journal-title":"Clin Exp Hepatol"},{"key":"10.1016\/j.iliver.2026.100234_bib112","article-title":"Macrophage metabolism in nonalcoholic fatty liver disease","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.iliver.2026.100234_bib113","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jhep.2024.01.029","article-title":"Nuclear miR-204-3p mitigates metabolic dysfunction-associated steatotic liver disease in mice","volume":"80","author":"Zou","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.iliver.2026.100234_bib114","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.eng.2024.05.005","article-title":"Therapeutic targeting of PKM2 ameliorates NASH fibrosis progression in a macrophage-specific and liver-specific manner","volume":"41","author":"Qu","year":"2024","journal-title":"Engineering"},{"issue":"6","key":"10.1016\/j.iliver.2026.100234_bib115","first-page":"377","article-title":"Innate immune signaling and gut-liver interactions in non-alcoholic fatty liver disease","volume":"3","author":"Bieghs","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib116","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000535524","article-title":"Mechanisms and therapeutic strategies for MAFLD targeting TLR4 signaling pathways","volume":"16","author":"Ren","year":"2024","journal-title":"J Innate Immun"},{"issue":"2","key":"10.1016\/j.iliver.2026.100234_bib117","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123294","article-title":"ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model","volume":"5","author":"Schuster-Gaul","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.iliver.2026.100234_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.767314","article-title":"Current and potential therapies targeting inflammation in NASH","volume":"12","author":"Albhaisi","year":"2021","journal-title":"Front Endocrinol"},{"issue":"11","key":"10.1016\/j.iliver.2026.100234_bib119","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3390\/biomedicines11113056","article-title":"Hepatic macrophages as targets for the MSC-based cell therapy in non-alcoholic steatohepatitis","volume":"11","author":"Kholodenko","year":"2023","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.iliver.2026.100234_bib120","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.3390\/ijms23126696","article-title":"Combined therapy with a CCR2\/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis","volume":"23","author":"Puengel","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.iliver.2026.100234_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1693753","article-title":"Immunometabolic integration in therapeutic strategies for managing MASLD","volume":"16","author":"Gonz\u00e1lez-Serrano","year":"2025","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib122","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s44161-023-00295-x","article-title":"Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications","volume":"2","author":"Dib","year":"2023","journal-title":"Nat Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.iliver.2026.100234_bib123","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004584","article-title":"Lipid-loaded macrophages as new therapeutic target in cancer","volume":"10","author":"Marelli","year":"2022","journal-title":"J Immunother Cancer"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib124","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2085432","article-title":"Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression","volume":"11","author":"Liu","year":"2022","journal-title":"OncoImmunology"},{"key":"10.1016\/j.iliver.2026.100234_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114554","article-title":"GPNMB regulates the differentiation and transformation of monocyte-derived macrophages during MASLD","volume":"154","author":"Wang","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.iliver.2026.100234_bib126","article-title":"Regulation of lipoprotein processing by GPNMB in foamy macrophages: potential therapeutic targets for atherosclerosis","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun"}],"container-title":["iLIVER"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772947826000186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772947826000186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:25:49Z","timestamp":1781825149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772947826000186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2772947826000186"],"URL":"https:\/\/doi.org\/10.1016\/j.iliver.2026.100234","relation":{},"ISSN":["2772-9478"],"issn-type":[{"value":"2772-9478","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterogeneity of hepatic macrophages in MASLD\/MASH: Lipid-associated programs, molecular mechanisms, spatial niches, and therapeutic implications","name":"articletitle","label":"Article Title"},{"value":"iLIVER","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iliver.2026.100234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press.","name":"copyright","label":"Copyright"}],"article-number":"100234"}}