{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:50:09Z","timestamp":1773042609600,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.imbio.2006.03.004","type":"journal-article","created":{"date-parts":[[2006,6,11]],"date-time":"2006-06-11T09:58:40Z","timestamp":1150019920000},"page":"701-709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age-dependent loss of na\u00efve T cells in TCR transgenic bone marrow chimeras"],"prefix":"10.1016","volume":"211","author":[{"given":"Clenton","family":"Coleman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koko","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monte V.","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2006.03.004_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.iy.09.040191.001543","article-title":"The SCID mouse mutant: definition, characterization, and potential uses","volume":"9","author":"Bosma","year":"1991","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib2","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.4049\/jimmunol.138.10.3120","article-title":"Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation","volume":"138","author":"Budd","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib3","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4049\/jimmunol.131.5.2445","article-title":"Characterization of the murine T cell surface molecule, designated L3T4, identified by the monoclonal antibody GK-1.5: similarity of L3T4 to the human Leu-3\/T4 molecule","volume":"131","author":"Dialynas","year":"1983","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.immunol.16.1.201","article-title":"T cell memory","volume":"16","author":"Dutton","year":"1998","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib5","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.4049\/jimmunol.142.5.1413","article-title":"Stimulation of murine T cell subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules","volume":"142","author":"Ernst","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib6","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.4049\/jimmunol.145.5.1295","article-title":"Differences in the expression profiles of CD45RB, Pgp-1 and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice","volume":"145","author":"Ernst","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib7","series-title":"Chance, Development, and Aging","author":"Finch","year":"2000"},{"key":"10.1016\/j.imbio.2006.03.004_bib8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1172\/JCI110143","article-title":"Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans","volume":"67","author":"Gillis","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2006.03.004_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0008-8749(03)00007-8","article-title":"Age-related changes in mature CD4+ T cells: cell cycle analysis","volume":"220","author":"Hale","year":"2003","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib10","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.157.4.1149","article-title":"The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody","volume":"157","author":"Haskins","year":"1983","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2006.03.004_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0047-6374(96)01826-X","article-title":"Age-related changes in CD4 T cells of T cell receptor transgenic mice","volume":"93","author":"Haynes","year":"1997","journal-title":"Mech. Age. Dev."},{"key":"10.1016\/j.imbio.2006.03.004_bib12","doi-asserted-by":"crossref","first-page":"15053","DOI":"10.1073\/pnas.2433717100","article-title":"CD4 T cell memory derived from young na\u00efve cells functions well into old age, but memory generated from aged na\u00efve cells functions poorly","volume":"100","author":"Haynes","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imbio.2006.03.004_bib13","series-title":"Immunology and Aging","first-page":"51","article-title":"The thymus and aging","author":"Hirokawa","year":"1977"},{"key":"10.1016\/j.imbio.2006.03.004_bib14","series-title":"Human Cytokines: Their Role in Disease and Therapy","first-page":"353","article-title":"The role of cytokines in aging","author":"Hobbs","year":"1995"},{"key":"10.1016\/j.imbio.2006.03.004_bib15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/1074-7613(94)90084-1","article-title":"Visualization of peptide-specific T cell immunity in vivo","volume":"1","author":"Kearney","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2006.03.004_bib16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20011756","article-title":"Two subsets of na\u00efve T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood","volume":"195","author":"Kimmig","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2006.03.004_bib17","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/eji.200526181","article-title":"Post-thymic in vivo proliferation of na\u00efve CD4+ T cells constrains the T cell repertoire in healthy human adults","volume":"35","author":"Kohler","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/eji.1830190604","article-title":"Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A","volume":"19","author":"Lerner","year":"1989","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib19","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.4049\/jimmunol.168.12.6120","article-title":"Early antigen-specific response by na\u00efve CD8 T cells is not altered with aging","volume":"168","author":"Li","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib20","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.184.5.1891","article-title":"Antigen-independent changes in na\u00efve CD4 T cells with aging","volume":"184","author":"Linton","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2006.03.004_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.0105-2896.2005.00266.x","article-title":"Intrinsic versus environmental influences on T-cell responses in aging","volume":"205","author":"Linton","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imbio.2006.03.004_bib22","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1886::AID-IMMU1886>3.0.CO;2-M","article-title":"Thymic function in young\/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution","volume":"28","author":"Mackall","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0065-2776(08)60047-4","article-title":"Age influence on the immune system","volume":"29","author":"Makinodan","year":"1980","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4049\/jimmunol.176.1.301","article-title":"Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo","volume":"176","author":"Messaoudi","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mad.2003.10.004","article-title":"Antigen-specific CD4 T cell clonal expansion and differentiation in the aged lymphoid microenvironment. I. The primary T cell response is unaffected","volume":"125","author":"Mittler","year":"2004","journal-title":"Mech. Age. Dev."},{"key":"10.1016\/j.imbio.2006.03.004_bib26","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.4049\/jimmunol.165.4.1733","article-title":"Cutting edge: na\u00efve T cells masquerading as memory cells","volume":"165","author":"Murali-Krishna","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib27","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.2125367","article-title":"Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo","volume":"250","author":"Murphy","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.imbio.2006.03.004_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/eji.1830210206","article-title":"Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells","volume":"21","author":"Nagelkerken","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib29","doi-asserted-by":"crossref","first-page":"7446","DOI":"10.4049\/jimmunol.174.11.7446","article-title":"The influence of age on T cell generation and TCR diversity","volume":"174","author":"Naylor","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-065X.1997.tb00959.x","article-title":"Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cells for the study of T-cell activation in vivo","volume":"156","author":"Pape","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imbio.2006.03.004_bib31","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4049\/jimmunol.148.5.1389","article-title":"CD4+CD8\u2212 thymocytes from neonatal mice induce IgM production in SCID mice","volume":"148","author":"Riggs","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2006.03.004_bib32","doi-asserted-by":"crossref","first-page":"711","DOI":"10.4049\/jimmunol.162.2.711","article-title":"Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population","volume":"162","author":"Timm","year":"1999","journal-title":"J. Immunol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129850600057X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129850600057X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:20:40Z","timestamp":1759249240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S017129850600057X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S017129850600057X"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2006.03.004","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-dependent loss of na\u00efve T cells in TCR transgenic bone marrow chimeras","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2006.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}