{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:19:07Z","timestamp":1762251547863,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.imbio.2009.08.007","type":"journal-article","created":{"date-parts":[[2009,9,19]],"date-time":"2009-09-19T05:00:19Z","timestamp":1253336419000},"page":"452-457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interferon-\u03b3-mediated pathways are induced in human CD34+ haematopoietic stem cells"],"prefix":"10.1016","volume":"215","author":[{"given":"Katharina","family":"Kurz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yordanka","family":"Gluhcheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissaveta","family":"Zvetkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenther","family":"Konwalinka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2009.08.007_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1099-1069(199806)16:2<57::AID-HON623>3.0.CO;2-#","article-title":"Stimulatory effects of neopterin on hematopoiesis in vitro are mediated by activation of stromal cell function","volume":"16","author":"Aizawa","year":"1998","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.imbio.2009.08.007_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/pteridines.1998.9.1.13","article-title":"In vivo stimulatory effects of neopterin on hematopoiesis","volume":"9","author":"Aizawa","year":"1998","journal-title":"Pteridines"},{"key":"10.1016\/j.imbio.2009.08.007_bib3","unstructured":"Atlas of Human Hematopoietic Colonies, 1995.Stem Cell Technologies Inc., Vancouver, Canada."},{"issue":"Suppl. 6","key":"10.1016\/j.imbio.2009.08.007_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/ndt\/10.supp6.27","article-title":"Cellular mechanism of resistance to erythropoietin","volume":"10","author":"Casadevall","year":"1995","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.imbio.2009.08.007_bib5","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1182\/blood.V93.10.3309.410k04_3309_3316","article-title":"Interferon gamma induces upregulation and activation of caspases 1, 3 and 8 to produce apoptoisi in human erythroid progenitor cells","volume":"93","author":"Dai","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2009.08.007_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-0609.1990.tb00374.x","article-title":"Correlation between neopterin, interferon-gamma and haemoglobin in patients with haematological disorders","volume":"44","author":"Denz","year":"1990","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.imbio.2009.08.007_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00002030-199102000-00012","article-title":"Negative correlation between blood cell counts and serum neopterin concentration in patients with HIV-1 infection","volume":"5","author":"Fuchs","year":"1991","journal-title":"AIDS"},{"key":"10.1016\/j.imbio.2009.08.007_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/10408369209114604","article-title":"The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases","volume":"29","author":"Fuchs","year":"1992","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.imbio.2009.08.007_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0609.1993.tb00147.x","article-title":"Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection","volume":"50","author":"Fuchs","year":"1993","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.imbio.2009.08.007_bib10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1749-6632.1994.tb55735.x","article-title":"Inhibitory cytokines in patients with anemia of chronic disorders","volume":"718","author":"Fuchs","year":"1994","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.imbio.2009.08.007_bib11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S0140-6736(89)92912-7","article-title":"Cellular immune activation and erythropoiesis in gynaecological cancer","volume":"1","author":"Fuith","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2009.08.007_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/ajcp\/101.3.338","article-title":"Serum levels of erythropoietin and selected other cytokines in patients with anemia of chronic disease","volume":"101","author":"Greendyke","year":"1994","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.imbio.2009.08.007_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1248\/bpb.29.43","article-title":"Effects of neopterin on the hematopoietic microenvironment of senescence-accelerated mice (SAM)","volume":"29","author":"Kanbe","year":"2006","journal-title":"Biol Pharm Bull."},{"key":"10.1016\/j.imbio.2009.08.007_bib14","first-page":"71","article-title":"A micro agar culture system for cloning human erythropoietic progenitors in vitro","volume":"1","author":"Konwalinka","year":"1982","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.imbio.2009.08.007_bib15","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1172\/JCI111853","article-title":"Suppression of normal human erythropoiesis by gamma interferon in vitro: role of monocytes and T lymphocytes","volume":"75","author":"Mamus","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2009.08.007_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/stem.5530130105","article-title":"Pathogenesis of the anemia of chronic disease: a cytokine-mediated anemia","volume":"13","author":"Means","year":"1995","journal-title":"Stem Cells"},{"key":"10.1016\/j.imbio.2009.08.007_bib17","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1182\/blood-2003-11-3909","article-title":"Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation","volume":"103","author":"Meisel","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2009.08.007_bib18","first-page":"134","article-title":"Inflammatory biomarker, neopterin, suppresses B lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI\/SAM","volume":"232","author":"Minami","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.imbio.2009.08.007_bib19","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T cell proliferation by macrophage tryptophan catabolism","volume":"189","author":"Munn","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2009.08.007_bib20","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1182\/blood.V87.10.4149.bloodjournal87104149","article-title":"Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition","volume":"87","author":"Selleri","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2009.08.007_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/10428199409049670","article-title":"Hematopoietic progenitors and synergism of interferon-gamma and stem cell factor","volume":"14","author":"Shiohara","year":"1994","journal-title":"Leuk. Lymphoma."},{"key":"10.1016\/j.imbio.2009.08.007_bib22","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1182\/blood.V71.6.1590.1590","article-title":"Gamma-interferon modulates human monocyte\/macrophage transferrin receptor expression","volume":"71","author":"Taetle","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2009.08.007_bib23","doi-asserted-by":"crossref","unstructured":"Tsuboi, I., Harada, T., Hirabayashi, Y., Kanno, J., Inoue, T., Aizawa, S., 2009. Inflammatory biomarker, neopterin, predominantly enhances myelopoiesis, which suppresses erythropoiesis via activated stromal cells. Immunobiology (Epub ahead of print)","DOI":"10.1016\/j.imbio.2009.05.004"},{"key":"10.1016\/j.imbio.2009.08.007_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/10428199809057590","article-title":"Interferon-gamma and human megakaryopoiesis","volume":"31","author":"Tsuji","year":"1998","journal-title":"Leuk. Lymphoma."},{"key":"10.1016\/j.imbio.2009.08.007_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jcp.1041620116","article-title":"Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development","volume":"162","author":"Wang","year":"1995","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.imbio.2009.08.007_bib26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","article-title":"Anemia of chronic disease","volume":"352","author":"Weiss","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2009.08.007_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1046\/j.0902-4441.2003.00197.x","article-title":"Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation","volume":"72","author":"Weiss","year":"2004","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.imbio.2009.08.007_bib28","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1093\/clinchem\/43.12.2424","article-title":"Simultaneous measurement of serum tryptophan and kynurenine by HPLC","volume":"43","author":"Widner","year":"1997","journal-title":"Clin. Chem."},{"key":"10.1016\/j.imbio.2009.08.007_bib29","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.2174\/0929867033457179","article-title":"Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects","volume":"10","author":"Wirleitner","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.imbio.2009.08.007_bib30","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/QAI.0b013e318198a6e1","article-title":"Parameters of cellular immune activation in vivo correlate with the proliferative capacity of peripheral blood mononuclear cells in vitro in HIV-infected patients","volume":"50","author":"Zangerle","year":"2009","journal-title":"J. Aquir. Immune Defic. Syndr."},{"key":"10.1016\/j.imbio.2009.08.007_bib31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1073\/pnas.82.1.188","article-title":"Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo","volume":"82","author":"Zoumbos","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298509001478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298509001478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:25:17Z","timestamp":1759249517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298509001478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0171298509001478"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2009.08.007","relation":{},"ISSN":["0171-2985"],"issn-type":[{"type":"print","value":"0171-2985"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon-\u03b3-mediated pathways are induced in human CD34+ haematopoietic stem cells","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2009.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}