{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:02:41Z","timestamp":1790938961824,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.imbio.2011.07.028","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T23:47:34Z","timestamp":1312328854000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Complement-mediated injury and protection of endothelium: Lessons from atypical haemolytic uraemic syndrome"],"prefix":"10.1016","volume":"217","author":[{"given":"Heather","family":"Kerr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 3","key":"10.1016\/j.imbio.2011.07.028_bib0005","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/S0049-3848(11)70020-2","article-title":"New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications","volume":"127","author":"Ahmed","year":"2011","journal-title":"Thromb. Res."},{"key":"10.1016\/j.imbio.2011.07.028_bib0010","doi-asserted-by":"crossref","first-page":"18882","DOI":"10.1074\/jbc.M109.009886","article-title":"Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow","volume":"284","author":"Ali","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2011.07.028_bib0015","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/j.1523-1755.2005.00260.x","article-title":"Glomerular endothelial cell differentiation","volume":"67","author":"Ballermann","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2011.07.028_bib0020","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.4049\/jimmunol.160.7.3342","article-title":"Identification of the second heparin-binding domain in human complement factor H","volume":"160","author":"Blackmore","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0025","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.4049\/jimmunol.180.9.6385","article-title":"A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity","volume":"180","author":"Blom","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0030","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0161-5890(02)00215-8","article-title":"The endothelium as physiological source of properdin: role of wall shear stress","volume":"39","author":"Bongrazio","year":"2003","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0035","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1007\/s00125-010-1910-x","article-title":"Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus","volume":"53","author":"Broekhuizen","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.imbio.2011.07.028_bib0040","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.4049\/jimmunol.142.6.2024","article-title":"Biosynthesis of complement factor H by human umbilical vein endothelial cells. Regulation by T cell growth factor and IFN-gamma","volume":"142","author":"Brooimans","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0045","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/eji.1830220324","article-title":"CD59 expressed by human endothelial cells functions as a protective molecule against complement-mediated lysis","volume":"22","author":"Brooimans","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0050","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/eji.1830221216","article-title":"Relative roles of decay-accelerating factor, membrane cofactor protein, and CD59 in the protection of human endothelial cells against complement-mediated lysis","volume":"22","author":"Brooimans","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2004.04.013","article-title":"Antiphospholipid antibodies bind to activated but not resting endothelial cells: is an independent triggering event required to induce antiphospholipid antibody-mediated disease?","volume":"114","author":"Chen","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.imbio.2011.07.028_bib0060","first-page":"3527","article-title":"Endothelial cells in physiology and in the pathophysiology of vascular disorders","volume":"91","author":"Cines","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2011.07.028_bib0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nm.2261","article-title":"Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome","volume":"17","author":"Clement","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0070","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00467-007-0518-y","article-title":"Streptococcus pneumoniae-associated hemolytic uremic syndrome","volume":"23","author":"Copelovitch","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0075","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/eji.1830200808","article-title":"Expression of complement alternative pathway proteins by endothelial cells. Differential regulation by interleukin 1 and glucocorticoids","volume":"20","author":"Dauchel","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0080","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.170.3.637","article-title":"CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells","volume":"170","author":"Davies","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1681\/ASN.2010050451","article-title":"The development of atypical hemolytic uremic syndrome depends on complement C5","volume":"22","author":"de Jorge","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1056\/NEJMoa0810739","article-title":"Thrombomodulin mutations in atypical hemolytic-uremic syndrome","volume":"361","author":"Delvaeye","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0095","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/01.ASN.0000132474.50966.DA","article-title":"Endothelial dysfunction","volume":"15","author":"Endemann","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0100","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"Eremina","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0105","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.molimm.2005.11.008","article-title":"Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree","volume":"43","author":"Esparza-Gordillo","year":"2006","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0110","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ki.2010.132","article-title":"Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice","volume":"78","author":"Fakhouri","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2011.07.028_bib0115","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0120","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.4049\/jimmunol.0804031","article-title":"The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome","volume":"182","author":"Ferreira","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0125","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1136\/jmg.2004.019083","article-title":"Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome","volume":"41","author":"Fremeaux-Bacchi","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.imbio.2011.07.028_bib0130","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1172\/JCI30954","article-title":"Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine","volume":"117","author":"Galeano","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2011.07.028_bib0135","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/bj2360313","article-title":"Structure and function of heparan sulphate proteoglycans","volume":"236","author":"Gallagher","year":"1986","journal-title":"Biochem. J"},{"key":"10.1016\/j.imbio.2011.07.028_bib0140","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/HYPERTENSIONAHA.109.141937","article-title":"Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placental ischemia-induced hypertension","volume":"55","author":"Gilbert","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.imbio.2011.07.028_bib0145","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1582-4934.2008.00350.x","article-title":"The alternative complement pathway revisited","volume":"12","author":"Harboe","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0150","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2249.2004.02627.x","article-title":"The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation","volume":"138","author":"Harboe","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0155","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1016\/S0021-9258(18)81901-9","article-title":"Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface","volume":"264","author":"Hattori","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2011.07.028_bib0160","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1432-2277.2004.00075.x","article-title":"Clearance of complement by human vascular endothelial cells: effects of hypoxia\/reoxygenation and IL-1beta activation","volume":"18","author":"Haun","year":"2005","journal-title":"Transpl. Int."},{"key":"10.1016\/j.imbio.2011.07.028_bib0165","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.4049\/jimmunol.160.12.6128","article-title":"Complement activation occurs on subendothelial extracellular matrix in vitro and is initiated by retraction or removal of overlying endothelial cells","volume":"160","author":"Hindmarsh","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0170","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0968-0004(92)90325-4","article-title":"Clusterin: the intriguing guises of a widely expressed glycoprotein","volume":"17","author":"Jenne","year":"1992","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.imbio.2011.07.028_bib0175","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00467-010-1555-5","article-title":"Genetics and complement in atypical HUS","volume":"25","author":"Kavanagh","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0180","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.med.59.060106.185110","article-title":"Complement regulatory genes and hemolytic uremic syndromes","volume":"59","author":"Kavanagh","year":"2008","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0185","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1681\/ASN.2006050419","article-title":"A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease","volume":"17","author":"Keepers","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0190","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.4049\/jimmunol.155.3.1434","article-title":"Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin and ICAM-1","volume":"155","author":"Kilgore","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0195","doi-asserted-by":"crossref","first-page":"14636","DOI":"10.1074\/jbc.M800362200","article-title":"KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature","volume":"283","author":"Kinderlerer","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2011.07.028_bib0200","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1182\/blood-2008-04-152934","article-title":"Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin","volume":"113","author":"Kinderlerer","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2011.07.028_bib0205","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.molimm.2010.05.011","article-title":"New insights into the molecular mechanisms of classical complement activation","volume":"47","author":"Kojouharova","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00441-008-0642-4","article-title":"Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer","volume":"335","author":"Langenkamp","year":"2009","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.imbio.2011.07.028_bib0215","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/HYPERTENSIONAHA.107.092098","article-title":"Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia","volume":"50","author":"Li","year":"2007","journal-title":"Hypertension"},{"issue":"Suppl. 8","key":"10.1016\/j.imbio.2011.07.028_bib0220","doi-asserted-by":"crossref","first-page":"I22","DOI":"10.1016\/j.vaccine.2008.11.001","article-title":"Inhibiting complement activation on cells at the step of C3 cleavage","volume":"26","author":"Liszewski","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2011.07.028_bib0225","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0065-2776(08)60868-8","article-title":"Control of the complement system","volume":"61","author":"Liszewski","year":"1996","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0230","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.iy.09.040191.002243","article-title":"Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster","volume":"9","author":"Liszewski","year":"1991","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0235","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ki.2009.131","article-title":"A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome","volume":"76","author":"Lofling","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2011.07.028_bib0240","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.iy.07.040189.000343","article-title":"Decay-accelerating factor: biochemistry, molecular biology, and function","volume":"7","author":"Lublin","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0245","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1172\/JCI16651","article-title":"Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome","volume":"111","author":"Manuelian","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2011.07.028_bib0250","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1016\/S0021-9258(17)38421-1","article-title":"Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan","volume":"261","author":"Marcum","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2011.07.028_bib0255","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/01.RES.0000038151.57577.19","article-title":"Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury","volume":"91","author":"Mason","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.imbio.2011.07.028_bib0260","doi-asserted-by":"crossref","first-page":"C578","DOI":"10.1152\/ajpcell.00339.2001","article-title":"bFGF and VEGF synergistically enhance endothelial cytoprotection via decay-accelerating factor induction","volume":"282","author":"Mason","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0265","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/1529-0131(200101)44:1<138::AID-ANR18>3.0.CO;2-G","article-title":"Induction of endothelial cell decay-accelerating factor by vascular endothelial growth factor: a mechanism for cytoprotection against complement-mediated injury during inflammatory angiogenesis","volume":"44","author":"Mason","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imbio.2011.07.028_bib0270","doi-asserted-by":"crossref","first-page":"41611","DOI":"10.1074\/jbc.M407981200","volume":"279","author":"Mason","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2011.07.028_bib0275","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1182\/blood.V94.5.1673","article-title":"Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition","volume":"94","author":"Mason","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2011.07.028_bib0280","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1172\/JCI112104","article-title":"Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes","volume":"76","author":"Matzner","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2011.07.028_bib0285","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-2249.1993.tb05956.x","article-title":"Vitronectin-mediated inhibition of complement: evidence for different binding sites for C5b-7 and C9","volume":"92","author":"Milis","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0290","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1055\/s-0030-1253448","article-title":"Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences","volume":"36","author":"Molema","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.imbio.2011.07.028_bib0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2640001","article-title":"Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects","volume":"264","author":"Morgan","year":"1989","journal-title":"Biochem. J"},{"key":"10.1016\/j.imbio.2011.07.028_bib0300","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4049\/jimmunol.138.1.246","article-title":"Recovery of human neutrophils from complement attack: removal of the membrane attack complex by endocytosis and exocytosis","volume":"138","author":"Morgan","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0305","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nsmb.2018","article-title":"Structural basis for engagement by complement factor H of C3b on a self surface","volume":"18","author":"Morgan","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0310","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1681\/ASN.V94590","article-title":"CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats","volume":"9","author":"Nangaku","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0315","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/intimm\/1.2.205","article-title":"A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement","volume":"1","author":"Okada","year":"1989","journal-title":"Int. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0320","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1172\/JCI6740","article-title":"VEGF(165) mediates glomerular endothelial repair","volume":"104","author":"Ostendorf","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2011.07.028_bib0325","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.171.4.1363","article-title":"Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection","volume":"171","author":"Platt","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0330","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1086\/318203","article-title":"Factor H mutations in hemolytic uremic syndrome cluster in exons 18\u201320, a domain important for host cell recognition","volume":"68","author":"Richards","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.imbio.2011.07.028_bib0335","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.molimm.2006.07.004","article-title":"Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome","volume":"44","author":"Richards","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0340","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1084\/jem.168.5.1917","article-title":"Interferon gamma induces synthesis of complement alternative pathway proteins by human endothelial cells in culture","volume":"168","author":"Ripoche","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0345","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000236861","article-title":"Role of endothelial cells in transplantation","volume":"106","author":"Robson","year":"1995","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0350","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1182\/blood-2009-01-197640","article-title":"Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome","volume":"114","author":"Roumenina","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2011.07.028_bib0355","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1084\/jem.182.6.1807","article-title":"Complement-mediated regulation of tissue factor activity in endothelium","volume":"182","author":"Saadi","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0360","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1084\/jem.181.1.21","article-title":"Transient perturbation of endothelial integrity induced by natural antibodies and complement","volume":"181","author":"Saadi","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0365","doi-asserted-by":"crossref","first-page":"e1001013","DOI":"10.1371\/journal.pmed.1001013","article-title":"Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort","volume":"8","author":"Salmon","year":"2011","journal-title":"PLoS Med."},{"key":"10.1016\/j.imbio.2011.07.028_bib0370","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pep.2010.12.002","article-title":"Production of biologically active complement factor H in therapeutically useful quantities","volume":"76","author":"Schmidt","year":"2011","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.imbio.2011.07.028_bib0375","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ki.1997.101","article-title":"TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells","volume":"51","author":"Sheerin","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2011.07.028_bib0380","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/scel.1995.0037","article-title":"Induction of cellular procoagulant activity by the membrane attack complex of complement","volume":"6","author":"Sims","year":"1995","journal-title":"Semin. Cell Biol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0385","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.intimp.2007.07.014","article-title":"Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator","volume":"7","author":"Skidgel","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0390","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1681\/ASN.2007030356","article-title":"New approaches to the treatment of dense deposit disease","volume":"18","author":"Smith","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0395","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.4049\/jimmunol.179.4.2600","article-title":"Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly","volume":"179","author":"Spitzer","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0400","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.molimm.2009.04.012","article-title":"A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome","volume":"46","author":"Stahl","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0405","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.ATV.18.5.677","article-title":"Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force","volume":"18","author":"Traub","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0410","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/01.CIR.101.4.352","article-title":"Laminar shear stress upregulates the complement-inhibitory protein clusterin: a novel potent defense mechanism against complement-induced endothelial cell activation","volume":"101","author":"Urbich","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.imbio.2011.07.028_bib0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imbio.2009.08.006","article-title":"Paths reunited: initiation of the classical and lectin pathways of complement activation","volume":"215","author":"Wallis","year":"2010","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2011.07.028_bib0420","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00467-010-1556-4","article-title":"aHUS caused by complement dysregulation: new therapies on the horizon","volume":"26","author":"Waters","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.imbio.2011.07.028_bib0425","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00467-010-1522-1","article-title":"Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction","volume":"25","author":"Zoja","year":"2010","journal-title":"Pediatr. Nephrol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298511001690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298511001690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:30:13Z","timestamp":1759249813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298511001690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0171298511001690"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2011.07.028","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement-mediated injury and protection of endothelium: Lessons from atypical haemolytic uraemic syndrome","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2011.07.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}