{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:01:10Z","timestamp":1778781670080,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.imbio.2011.11.003","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T23:16:50Z","timestamp":1321658210000},"page":"652-656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure"],"prefix":"10.1016","volume":"217","author":[{"given":"Marina","family":"Harutyunyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia S.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp-Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kastrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2011.11.003_bib0005","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cca.2011.01.022","article-title":"Plasma YKL-40 levels in healthy subjects from the general population","volume":"412","author":"Bojesen","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.imbio.2011.11.003_bib0010","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/01.ATV.19.3.687","article-title":"Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages","volume":"19","author":"Boot","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0015","doi-asserted-by":"crossref","first-page":"xiii","DOI":"10.1016\/j.hfc.2009.05.002","article-title":"Biomarkers in heart failure. Preface","volume":"5","author":"Braunwald","year":"2009","journal-title":"Heart Fail. Clin."},{"key":"10.1016\/j.imbio.2011.11.003_bib0020","doi-asserted-by":"crossref","first-page":"15332","DOI":"10.1074\/jbc.M110.212514","article-title":"Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma","volume":"286","author":"Francescone","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2011.11.003_bib0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/117727190800300003","article-title":"Expression of osteoarthritis marker YKL-39 is stimulated by transforming growth factor beta (TGF-beta) and IL-4 in differentiating macrophages","volume":"3","author":"Gratchev","year":"2008","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.imbio.2011.11.003_bib0030","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijcard.2005.01.016","article-title":"B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide are comparably useful for disease monitoring in heart failure","volume":"106","author":"Hammerer-Lercher","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/00365513.2010.538081","article-title":"High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR trial","volume":"71","author":"Harutyunyan","year":"2011","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.imbio.2011.11.003_bib0040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/00365510903518191","article-title":"Plasma YKL-40 and recovery of left ventricular function after acute myocardial infarction","volume":"70","author":"Hedegaard","year":"2010","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.imbio.2011.11.003_bib0045","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2217\/fon.09.66","article-title":"Plasma YKL-40: a potential new cancer biomarker?","volume":"5","author":"Johansen","year":"2009","journal-title":"Future Oncol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1349-7006.2005.00026.x","article-title":"Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells","volume":"96","author":"Junker","year":"2005","journal-title":"Cancer Sci."},{"key":"10.1016\/j.imbio.2011.11.003_bib0055","article-title":"Can YKL-40 be a new inflammatory biomarker in cardiovascular disease?","author":"Kastrup","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2011.11.003_bib0060","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/eurheartj\/ehp049","article-title":"High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease","volume":"30","author":"Kastrup","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.imbio.2011.11.003_bib0065","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/oxfordjournals.eurheartj.a060443","article-title":"An echocardiographic method for selecting high risk patients shortly after acute myocardial infarction, for inclusion in multi-centre studies (as used in the TRACE study). TRAndolapril Cardiac Evaluation","volume":"15","author":"Kober","year":"1994","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.imbio.2011.11.003_bib0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/MCA.0b013e328241d991","article-title":"Serum YKL-40 levels in patients with coronary artery disease","volume":"18","author":"Kucur","year":"2007","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.imbio.2011.11.003_bib0075","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/117727190700200023","article-title":"Human chitinases and chitinase-like proteins as indicators for inflammation and cancer","volume":"2","author":"Kzhyshkowska","year":"2007","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.imbio.2011.11.003_bib0080","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1182\/blood-2005-07-2843","article-title":"Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway","volume":"107","author":"Kzhyshkowska","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2011.11.003_bib0085","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-physiol-012110-142250","article-title":"Role of chitin and chitinase\/chitinase-like proteins in inflammation, tissue remodeling, and injury","volume":"73","author":"Lee","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0090","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.4049\/jimmunol.181.7.5167","article-title":"YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages","volume":"181","author":"Letuve","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0095","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1681\/ASN.V10112426","article-title":"Dietary protein restriction and the progression of chronic renal disease: what have all of the results of the MDRD study shown? Modification of diet in Renal Disease Study group","volume":"10","author":"Levey","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0100","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/00365513.2011.586470","article-title":"Plasma YKL-40 in relation to the degree of coronary artery disease in patients with stable ischemic heart disease","volume":"71","author":"Mathiasen","year":"2011","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.imbio.2011.11.003_bib0105","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2217\/bmm.10.58","article-title":"YKL-40: a new biomarker in cardiovascular disease?","volume":"4","author":"Mathiasen","year":"2010","journal-title":"Biomark. Med."},{"key":"10.1016\/j.imbio.2011.11.003_bib0110","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00011-010-0266-5","article-title":"The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease","volume":"60","author":"Mygind","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.imbio.2011.11.003_bib0115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/MCA.0b013e3282f40dd5","article-title":"Serum levels of YKL-40 increases in patients with acute myocardial infarction","volume":"19","author":"Nojgaard","year":"2008","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.imbio.2011.11.003_bib0120","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cardfail.2008.02.014","article-title":"Extracellular matrix turnover and inflammatory markers independently predict functional status and outcome in chronic heart failure","volume":"14","author":"Radauceanu","year":"2008","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.imbio.2011.11.003_bib0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/14017430903402218","article-title":"Plasma YKL-40 levels are elevated in patients with chronic heart failure","volume":"44","author":"Rathcke","year":"2010","journal-title":"Scand. Cardiovasc. J."},{"key":"10.1016\/j.imbio.2011.11.003_bib0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2337\/dc08-1144","article-title":"YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria","volume":"32","author":"Rathcke","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.imbio.2011.11.003_bib0135","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1373\/clinchem.2008.117192","article-title":"Concentrations of C-reactive protein and B-type natriuretic peptide 30 days after acute coronary syndromes independently predict hospitalization for heart failure and cardiovascular death","volume":"55","author":"Scirica","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.imbio.2011.11.003_bib0140","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.amjcard.2007.08.038","article-title":"Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure","volume":"101","author":"Tang","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1475-2840-9-86","article-title":"Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease","volume":"9","author":"Thomsen","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.imbio.2011.11.003_bib0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejheart.2007.10.012","article-title":"A randomised trial of a pre-synaptic stimulator of DA2-dopaminergic and alpha2-adrenergic receptors on morbidity and mortality in patients with heart failure","volume":"10","author":"Torp-Pedersen","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.imbio.2011.11.003_bib0155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/14017430802220567","article-title":"YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease","volume":"42","author":"Wang","year":"2008","journal-title":"Scand. Cardiovasc. J."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298511002506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298511002506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:33:20Z","timestamp":1759250000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298511002506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0171298511002506"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2011.11.003","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2011.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}