{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:40:24Z","timestamp":1776872424260,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":4147,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.imbio.2012.01.005","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T15:05:52Z","timestamp":1326207952000},"page":"935-941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["C5a receptor is cleaved by metalloproteases induced by sphingomyelinase D from Loxosceles spider venom"],"prefix":"10.1016","volume":"217","author":[{"given":"Carmen W.","family":"van den Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rute M.","family":"Gon\u00e7alves-de-Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthya K.","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise V.","family":"Tambourgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2012.01.005_bib0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0143-4160(88)90034-6","article-title":"The use of fura-2 to determine the relationship between cytoplasmic free Ca2+ and oxidase activation in rat neutrophils","volume":"9","author":"Al-Mohanna","year":"1988","journal-title":"Cell Calcium"},{"key":"10.1016\/j.imbio.2012.01.005_bib0010","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/jmedent\/28.3.477","article-title":"Human envenomization by Plectreurys tristis Simon (Araneae: Plectreuridae): a case report","volume":"28","author":"Carpenter","year":"1991","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0015","doi-asserted-by":"crossref","first-page":"14446","DOI":"10.1016\/S0021-9258(17)36643-7","article-title":"The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs","volume":"269","author":"DeMartino","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.01.005_bib0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000441-199210000-00008","article-title":"Loxoscelism","volume":"304","author":"Futrell","year":"1992","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.imbio.2012.01.005_bib0025","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.23.021704.115835","article-title":"Role of C5a in inflammatory responses","volume":"23","author":"Guo","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0030","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1128\/iai.64.6.1984-1991.1996","article-title":"Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis","volume":"64","author":"Jagels","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.01.005_bib0035","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/jmr.851","article-title":"Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin","volume":"20","author":"Kaczur","year":"2007","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.imbio.2012.01.005_bib0040","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.125.2.461","article-title":"Membrane proximal cleavage of L-selectin: identification of the cleavage site and a 6-kD transmembrane peptide fragment of L-selectin","volume":"125","author":"Kahn","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jlb.61.3.329","article-title":"Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure\/function relationships","volume":"61","author":"Kew","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-5793(94)00350-5","article-title":"Amino acids 327\u2013350 of the human C5a-receptor are not essential for [125I]C5a binding in COS cells and signal transduction in Xenopus oocytes","volume":"344","author":"Klos","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.imbio.2012.01.005_bib0055","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.molimm.2009.04.027","article-title":"The role of the anaphylatoxins in health and disease","volume":"46","author":"Klos","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0060","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jlb.54.4.283","article-title":"Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators","volume":"54","author":"Lee","year":"1993","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0065","doi-asserted-by":"crossref","first-page":"18592","DOI":"10.1074\/jbc.M310836200","article-title":"Regulated shedding of PAR1 N-terminal exodomain from endothelial cells","volume":"279","author":"Ludeman","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.01.005_bib0070","first-page":"13","article-title":"C5a stimulus-secretion coupling in rat basophilic leukaemia (RBL-2H3) cells transfected with the human C5a receptor is mediated by pertussis and cholera toxin-sensitive G proteins","volume":"32","author":"Monk","year":"1994","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.imbio.2012.01.005_bib0075","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.bjp.0707332","article-title":"Function, structure and therapeutic potential of complement C5a receptors","volume":"152","author":"Monk","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.semcdb.2008.09.004","article-title":"Regulation of the proteolytic disintegrin metalloproteinases, the \u2018Sheddases\u2019","volume":"20","author":"Murphy","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.jid.5700049","article-title":"Role of matrix metalloproteinases in HaCaT keratinocytes apoptosis induced by loxosceles venom sphingomyelinase D","volume":"126","author":"Paixao-Cavalcante","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0090","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.molimm.2010.07.003","article-title":"Human complement activation and anaphylatoxins generation induced by snake venom toxins from Bothrops genus","volume":"47","author":"Pidde-Queiroz","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1172\/JCI0215409","article-title":"Increased C5a receptor expression in sepsis","volume":"110","author":"Riedemann","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2012.01.005_bib0100","doi-asserted-by":"crossref","first-page":"47929","DOI":"10.1074\/jbc.M400129200","article-title":"Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival","volume":"279","author":"Schafer","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.01.005_bib0105","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/00000658-200204000-00014","article-title":"Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo","volume":"235","author":"Seely","year":"2002","journal-title":"Ann. Surg."},{"key":"10.1016\/j.imbio.2012.01.005_bib0110","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1073\/pnas.91.4.1214","article-title":"Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors","volume":"91","author":"Siciliano","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2012.01.005_bib0115","first-page":"90","article-title":"The role of polymorphonuclear leukocytes in the lesion caused by the venom of the brown spider, Loxosceles reclusa","volume":"22","author":"Smith","year":"1970","journal-title":"Lab Invest."},{"key":"10.1016\/j.imbio.2012.01.005_bib0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clindermatol.2005.11.006","article-title":"Loxoscelism","volume":"24","author":"Swanson","year":"2006","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0125","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.4049\/jimmunol.155.9.4459","article-title":"Incorporation of a 35-kilodalton purified protein from Loxosceles intermedia spider venom transforms human erythrocytes into activators of autologous complement alternative pathway","volume":"155","author":"Tambourgi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0130","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.1998.9474","article-title":"Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis","volume":"251","author":"Tambourgi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.imbio.2012.01.005_bib0135","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(97)00063-9","article-title":"Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators","volume":"36","author":"Tambourgi","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.imbio.2012.01.005_bib0140","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V95.2.683","article-title":"Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis","volume":"95","author":"Tambourgi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2012.01.005_bib0145","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molimm.2004.03.027","article-title":"Molecular cloning, expression, function and immunoreactivities of members of a gene family of sphingomyelinases from Loxosceles venom glands","volume":"41","author":"Tambourgi","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0150","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.0022-202X.2005.23654.x","article-title":"Loxosceles sphingomyelinase induces complement-dependent dermonecrosis, neutrophil infiltration, and endogenous gelatinase expression","volume":"124","author":"Tambourgi","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0155","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.toxicon.2010.01.021","article-title":"Loxoscelism: From basic research to the proposal of new therapies","volume":"56","author":"Tambourgi","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.imbio.2012.01.005_bib0160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/bj20021803","article-title":"Direct binding of a fragment of the Wiskott\u2013Aldrich syndrome protein to the C-terminal end of the anaphylatoxin C5a receptor","volume":"372","author":"Tardif","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.imbio.2012.01.005_bib0165","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1016\/j.yexcr.2006.08.027","article-title":"The shedding activity of ADAM17 is sequestered in lipid rafts","volume":"312","author":"Tellier","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.imbio.2012.01.005_bib0170","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1128\/MCB.15.11.6398","article-title":"Human pro-tumor necrosis factor: molecular determinants of membrane translocation, sorting, and maturation","volume":"15","author":"Utsumi","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0175","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1046\/j.1365-2567.2002.01468.x","article-title":"Loxosceles spider venom induces metalloproteinase mediated cleavage of MCP\/CD46 and MHCI and induces protection against C-mediated lysis","volume":"107","author":"van den Berg","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2012.01.005_bib0180","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1538-7836.2007.02382.x","article-title":"Loxosceles spider venom induces the release of thrombomodulin and endothelial protein C receptor: implications for the pathogenesis of intravascular coagulation as observed in loxoscelism","volume":"5","author":"van den Berg","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.imbio.2012.01.005_bib0185","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/path.2594","article-title":"Adamalysins in biology and disease","volume":"219","author":"van Goor","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.imbio.2012.01.005_bib0190","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1074\/jbc.C300563200","article-title":"Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine","volume":"279","author":"van Meeteren","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.01.005_bib0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1471-4159.2003.02303.x","article-title":"Lipid rafts identified as locations of ectodomain shedding mediated by Meltrin beta\/ADAM19","volume":"89","author":"Wakatsuki","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.imbio.2012.01.005_bib0200","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00109-009-0442-7","article-title":"Functions of C5a receptors","volume":"87","author":"Ward","year":"2009","journal-title":"J. Mol. Med."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512000095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512000095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:33:35Z","timestamp":1759250015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298512000095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0171298512000095"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2012.01.005","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C5a receptor is cleaved by metalloproteases induced by sphingomyelinase D from Loxosceles spider venom","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2012.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}