{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:00:55Z","timestamp":1759334455550,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":3935,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"KAKENHI","award":["23590505"],"award-info":[{"award-number":["23590505"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.imbio.2012.06.008","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T04:51:40Z","timestamp":1340772700000},"page":"527-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K"],"prefix":"10.1016","volume":"218","author":[{"given":"Itaru","family":"Hirai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Ebara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiro","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2012.06.008_bib0005","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1128\/IAI.67.3.1445-1449.1999","article-title":"Chlamydia pneumoniae infection in human monocytes","volume":"67","author":"Airenne","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.06.008_bib0010","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.phrs.2004.03.007","article-title":"mTOR: a protein kinase switching between life and death","volume":"50","author":"Asnaghi","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.imbio.2012.06.008_bib0015","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.febslet.2007.01.013","article-title":"Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle","volume":"581","author":"Bailey","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.imbio.2012.06.008_bib0020","doi-asserted-by":"crossref","first-page":"34676","DOI":"10.1074\/jbc.274.49.34676","article-title":"Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines","volume":"274","author":"Boonen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.06.008_bib0025","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1007\/s00018-010-0454-z","article-title":"AMP-activated protein kinase and its downstream transcriptional pathways","volume":"67","author":"Canto","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.imbio.2012.06.008_bib0030","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1038\/sj.onc.1208040","article-title":"P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation","volume":"23","author":"Casanovas","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.imbio.2012.06.008_bib0035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1046\/j.1462-5822.2002.00203.x","article-title":"Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells","volume":"4","author":"Coombes","year":"2002","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0040","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1128\/MCB.02199-06","article-title":"pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation","volume":"27","author":"De Santa","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0045","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.yexcr.2007.04.027","article-title":"Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines","volume":"313","author":"Dohda","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.imbio.2012.06.008_bib0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2141.2008.07433.x","article-title":"Dasatinib inhibits the proliferation and function of CD4+CD25+regulatory T cells","volume":"144","author":"Fei","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0055","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1128\/iai.64.5.1614-1620.1996","article-title":"Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells","volume":"64","author":"Gaydos","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.06.008_bib0060","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.4049\/jimmunol.164.10.5522","article-title":"Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10","volume":"164","author":"Geng","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0065","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1128\/jcm.33.9.2411-2414.1995","article-title":"In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae","volume":"33","author":"Godzik","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0070","first-page":"1485","article-title":"Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication","volume":"6","author":"Gong","year":"1995","journal-title":"Cell Growth Differ."},{"issue":"Suppl. 3","key":"10.1016\/j.imbio.2012.06.008_bib0075","doi-asserted-by":"crossref","first-page":"S402","DOI":"10.1086\/315596","article-title":"Background and current knowledge of Chlamydia pneumoniae and atherosclerosis","volume":"181","author":"Grayston","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2012.06.008_bib0080","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0898-6568(03)00038-X","article-title":"Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation","volume":"15","author":"Gutzkow","year":"2003","journal-title":"Cell. Signal."},{"key":"10.1016\/j.imbio.2012.06.008_bib0085","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.imbio.2012.06.008_bib0090","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1128\/IAI.69.12.7753-7759.2001","article-title":"Chlamydia pneumoniae infects and multiplies in lymphocytes in vitro","volume":"69","author":"Haranaga","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.06.008_bib0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1046\/j.1537-2995.2001.41091114.x","article-title":"Detection of Chlamydia pneumoniae antigenin PBMNCs of healthy blood donors","volume":"41","author":"Haranaga","year":"2001","journal-title":"Transfusion (Paris)"},{"key":"10.1016\/j.imbio.2012.06.008_bib0100","doi-asserted-by":"crossref","first-page":"891S","DOI":"10.3945\/ajcn.110.001925","article-title":"Sensing of energy and nutrients by AMP-activated protein kinase","volume":"93","author":"Hardie","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.imbio.2012.06.008_bib0105","doi-asserted-by":"crossref","first-page":"25722","DOI":"10.1074\/jbc.M203079200","article-title":"A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex","volume":"277","author":"Hirai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.06.008_bib0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1139\/W10-018","article-title":"Chlamydia pneumoniae infection suppresses Staphylococcus enterotoxin B-induced proliferation associated with down-expression of CD25 in lymphocytes","volume":"56","author":"Hirai","year":"2010","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0115","doi-asserted-by":"crossref","first-page":"31948","DOI":"10.1074\/jbc.M400638200","article-title":"Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes","volume":"279","author":"Hleb","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.06.008_bib0120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature07355","article-title":"The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth","volume":"456","author":"Huang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2012.06.008_bib0125","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S1286-4579(01)01458-7","article-title":"Chlamydia pneumoniae-infected monocytes exhibit increased adherence to human aortic endothelial cells","volume":"3","author":"Kalayoglu","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.imbio.2012.06.008_bib0130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cellimm.2007.09.002","article-title":"Long-term exposure to superantigen induces p27Kip1 and Bcl-2 expression in effector memory CD4+T cells","volume":"248","author":"Koyanagi","year":"2007","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0135","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control","volume":"10","author":"Ma","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1083\/jcb.200408161","article-title":"Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis","volume":"167","author":"Manning","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0145","doi-asserted-by":"crossref","first-page":"11106","DOI":"10.1128\/JVI.01063-07","article-title":"Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine\/threonine protein kinase mTOR pathway","volume":"81","author":"Minami","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0150","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jvs.2006.02.050","article-title":"Chlamydia pneumoniae and vascular disease: an update","volume":"43","author":"Mussa","year":"2006","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.imbio.2012.06.008_bib0155","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.4049\/jimmunol.1100393","article-title":"Chlamydia pneumoniae inhibits activated human T lymphocyte proliferation by the induction of apoptotic and pyroptotic pathways","volume":"186","author":"Olivares-Zavaleta","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0160","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.coi.2010.08.010","article-title":"mTOR signalling and metabolic regulation of T cell differentiation","volume":"22","author":"Peter","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0165","doi-asserted-by":"crossref","first-page":"S507","DOI":"10.1016\/S0002-8703(99)70287-5","article-title":"In vitro infection and pathogenesis of Chlamydia pneumoniae in endovascular cells","volume":"138","author":"Quinn","year":"1999","journal-title":"Am. Heart J."},{"key":"10.1016\/j.imbio.2012.06.008_bib0170","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ejca.2009.12.029","article-title":"Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1","volume":"46","author":"Sharif","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.imbio.2012.06.008_bib0175","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1046\/j.1365-2958.2001.02272.x","article-title":"Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery","volume":"39","author":"Subtil","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0180","first-page":"160","article-title":"Cytokine response of lymphocytes persistently infected with Chlamydia pneumoniae","volume":"50","author":"Takano","year":"2005","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0185","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semcdb.2004.11.005","article-title":"mTOR, translational control and human disease","volume":"16","author":"Tee","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0190","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1046\/j.1523-1755.1999.00704.x","article-title":"Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade","volume":"56","author":"Terada","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2012.06.008_bib0195","doi-asserted-by":"crossref","first-page":"33854","DOI":"10.1074\/jbc.M104395200","article-title":"Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines","volume":"276","author":"van Oirschot","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.06.008_bib0200","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.ppat.0020045","article-title":"Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival","volume":"2","author":"Verbeke","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imbio.2012.06.008_bib0205","first-page":"475","article-title":"GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress","volume":"19","author":"Watanabe","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.imbio.2012.06.008_bib0210","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/CS20070298","article-title":"Role of Chlamydia pneumoniae in atherosclerosis","volume":"114","author":"Watson","year":"2008","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.imbio.2012.06.008_bib0215","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1074\/jbc.273.26.16621","article-title":"Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies","volume":"273","author":"Weng","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2012.06.008_bib0220","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cellimm.2005.09.003","article-title":"Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes","volume":"237","author":"Wilson","year":"2005","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.imbio.2012.06.008_bib0225","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-6968.2002.tb11440.x","article-title":"A Chlamydia pneumoniae infection model using established human lymphocyte cell lines","volume":"216","author":"Yamaguchi","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.imbio.2012.06.008_bib0230","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/IAI.70.5.2392-2398.2002","article-title":"Chlamydia pneumoniae infection induces differentiation of monocytes into macrophages","volume":"70","author":"Yamaguchi","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.06.008_bib0235","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1537-2995.2004.04005.x","article-title":"Prevalence of viable Chlamydia pneumoniae in peripheral blood mononuclear cells of healthy blood donors","volume":"44","author":"Yamaguchi","year":"2004","journal-title":"Transfusion (Paris)"},{"issue":"4","key":"10.1016\/j.imbio.2012.06.008_bib0240","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.micpath.2008.06.005","article-title":"Inhibition of lymphocyte CD3 expression by Chlamydophila pneumoniae infection","volume":"45","author":"Yamaguchi","year":"2008","journal-title":"Microb. Pathog."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512001489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512001489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:35:43Z","timestamp":1759250143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298512001489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0171298512001489"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2012.06.008","relation":{},"ISSN":["0171-2985"],"issn-type":[{"type":"print","value":"0171-2985"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2012.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}