{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:27:31Z","timestamp":1791286051752,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.imbio.2012.10.003","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T20:07:22Z","timestamp":1350504442000},"page":"844-850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Role of complement in a murine model of peanut-induced anaphylaxis"],"prefix":"10.1016","volume":"218","author":[{"given":"Toshihisa","family":"Kodama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teizo","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2012.10.003_bib0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0165-2478(86)90049-0","article-title":"House dust allergen activates the classical complement pathway in mouse serum","volume":"13","author":"Beukelman","year":"1986","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imbio.2012.10.003_bib0010","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1081-1206(10)60908-8","article-title":"The impact of food allergy on the daily activities of children and their families","volume":"96","author":"Bollinger","year":"2006","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2249.2008.03748.x","article-title":"B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy","volume":"154","author":"Cardoso","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0020","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0022-3565(25)22175-9","article-title":"Activation of the third complement component (C3) and C3a generation in cardiac anaphylaxis: histamine release and associated inotropic and chronotropic effects","volume":"246","author":"del Balzo","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.imbio.2012.10.003_bib0025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.271.5247.348","article-title":"C3d of complement as a molecular adjuvant: bridging innate and acquired immunity","volume":"271","author":"Dempsey","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.imbio.2012.10.003_bib0030","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.4049\/jimmunol.167.8.4141","article-title":"Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy","volume":"167","author":"Drouin","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000227805","article-title":"Interactions of ficolin and mannose-binding lectin with fibrinogen\/fibrin augment the lectin complement pathway","volume":"2","author":"Endo","year":"2010","journal-title":"J. Innate Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0040","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jaci.2007.07.033","article-title":"Anaphylaxis: lessons from mouse models","volume":"120","author":"Finkelman","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0045","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4049\/jimmunol.151.3.1235","article-title":"Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine\u2013anti-cytokine antibody complexes","volume":"151","author":"Finkelman","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0050","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4049\/jimmunol.157.2.549","article-title":"Regulation of the B cell response to T-dependent antigens by classical pathway complement","volume":"157","author":"Fischer","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0055","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nri800","article-title":"Evolution of the lectin-complement pathway and its role in innate immunity","volume":"2","author":"Fujita","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0060","first-page":"S231","article-title":"Peanut allergy in three year old children a population based study","volume":"107","author":"Grundy","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0065","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/35023175","article-title":"A role for the C3a anaphylatoxin receptor in the effector phase of asthma","volume":"406","author":"Humbles","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2012.10.003_bib0070","doi-asserted-by":"crossref","first-page":"8626","DOI":"10.4049\/jimmunol.177.12.8626","article-title":"Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway","volume":"177","author":"Iwaki","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1172\/JCI200419082","article-title":"The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen","volume":"114","author":"Kawamoto","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2012.10.003_bib0080","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jaci.2008.11.004","article-title":"Peanuts can contribute to anaphylactic shock by activating complement","volume":"123","author":"Khodoun","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0085","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1164\/ajrccm.164.10.2010096","article-title":"Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma","volume":"164","author":"Krug","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.imbio.2012.10.003_bib0090","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.4049\/jimmunol.151.8.4295","article-title":"Mouse Crry\/p65. Characterization of monoclonal antibodies and the tissue distribution of a functional homologue of human MCP and DAF","volume":"151","author":"Li","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.275.5299.540","article-title":"Requirement for the transcription factor LSIRF\/IRF4 for mature B and T lymphocyte function","volume":"275","author":"Mittrucker","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.imbio.2012.10.003_bib0100","series-title":"Annual Meeting of the American Academy of Allergy, Asthma, and Immunology, vol. 123","first-page":"S113","article-title":"Economic and caregiver impacts of food allergy","author":"Perry","year":"2009"},{"key":"10.1016\/j.imbio.2012.10.003_bib0105","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1258\/0007142001903607","article-title":"Food anaphylaxis","volume":"56","author":"Sampson","year":"2000","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.imbio.2012.10.003_bib0110","first-page":"435","article-title":"IRF4-deficient lupus-prone MRL\/lpr mice lack serum Ig\/auto-Abs and Th17 cells but develop non-immune complex-mediated diffuse proliferative glomerulonephritis and dermatitis\/ear necrosis","volume":"62","author":"Sekine","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imbio.2012.10.003_bib0115","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0091-6749(03)02026-8","article-title":"Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study","volume":"112","author":"Sicherer","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0120","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.it.2008.11.003","article-title":"Complement activation and inhibition: a delicate balance","volume":"30","author":"Sjoberg","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0125","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1067\/mai.2001.112129","article-title":"The natural history of peanut allergy","volume":"107","author":"Skolnick","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0130","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.4049\/jimmunol.170.7.3835","article-title":"IL-4 exacerbates anaphylaxis","volume":"170","author":"Strait","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0135","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.4049\/jimmunol.179.10.6696","article-title":"Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses","volume":"179","author":"Sun","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0140","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tox.2005.07.023","article-title":"Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity","volume":"216","author":"Szebeni","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.imbio.2012.10.003_bib0145","doi-asserted-by":"crossref","first-page":"H1050","DOI":"10.1152\/ajpheart.00622.2005","article-title":"Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function","volume":"290","author":"Szebeni","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0150","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1084\/jem.20090633","article-title":"Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D","volume":"207","author":"Takahashi","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2012.10.003_bib0155","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.4049\/jimmunol.180.9.6132","article-title":"Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway","volume":"180","author":"Takahashi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0160","doi-asserted-by":"crossref","first-page":"8084","DOI":"10.1073\/pnas.0602357103","article-title":"Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation","volume":"103","author":"Taube","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2012.10.003_bib0165","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1128\/JVI.00082-09","article-title":"Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo","volume":"83","author":"Tian","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0170","first-page":"929","article-title":"Beta-blocker therapy and the risk of anaphylaxis","volume":"136","author":"Toogood","year":"1987","journal-title":"CMAJ"},{"key":"10.1016\/j.imbio.2012.10.003_bib0175","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0022-1759(12)80014-7","article-title":"ELISA of complement C3a in bronchoalveolar lavage fluid","volume":"147","author":"van de Graaf","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.imbio.2012.10.003_bib0180","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0161-5890(03)00023-3","article-title":"Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement","volume":"39","author":"Varga","year":"2003","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000094177","article-title":"Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis","volume":"141","author":"Windbichler","year":"2006","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0190","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.jaci.2006.01.048","article-title":"The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen","volume":"117","author":"Yalcindag","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.003_bib0195","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj1930621","article-title":"Purification and characterization of subcomponent C1q of the first component of mouse complement","volume":"193","author":"Yonemasu","year":"1981","journal-title":"Biochem. J."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512005050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512005050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:34:25Z","timestamp":1759250065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298512005050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0171298512005050"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2012.10.003","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of complement in a murine model of peanut-induced anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2012.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}