{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:07:56Z","timestamp":1781298476996,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Austrian Science Fund","award":["F4605"],"award-info":[{"award-number":["F4605"]}]},{"name":"Austrian Science Fund","award":["F4607"],"award-info":[{"award-number":["F4607"]}]},{"name":"Austrian Science Fund","award":["F4612"],"award-info":[{"award-number":["F4612"]}]},{"name":"Austrian Science Fund","award":["P23318-B11"],"award-info":[{"award-number":["P23318-B11"]}]},{"name":"Austrian Science Fund","award":["P23350-B11"],"award-info":[{"award-number":["P23350-B11"]}]},{"name":"Austrian Research Promotion Agency","award":["813003"],"award-info":[{"award-number":["813003"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.imbio.2012.10.008","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T22:17:12Z","timestamp":1351203432000},"page":"884-891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Passive immunization with allergen-specific IgG antibodies for treatment and prevention of allergy"],"prefix":"10.1016","volume":"218","author":[{"given":"Sabine","family":"Flicker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Linhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Wild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Wiedermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2012.10.008_bib0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000232170","article-title":"Immunoregulatory function of specific IgG. II. Clinical evaluation of combined active and passive immunotherapy","volume":"58","author":"Bernstein","year":"1979","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0010","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0091-6749(87)90245-4","article-title":"Combination of passive and active immunization in honeybee venom immunotherapy","volume":"79","author":"Bousquet","year":"1987","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0015","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/j.1460-2075.1989.tb03597.x","article-title":"The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene","volume":"8","author":"Breiteneder","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/j.imbio.2012.10.008_bib0020","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1084\/jem.62.6.733","article-title":"Serological evidence of immunity with co-existing sensitization in a type of human allergy (hay fever)","volume":"62","author":"Cooke","year":"1935","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2012.10.008_bib0025","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000076131","article-title":"Do mouse models of allergic asthma mimic clinical disease?","volume":"133","author":"Epstein","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0030","first-page":"141","article-title":"Passive immunization with allergen-specific antibodies","volume":"352","author":"Flicker","year":"2011","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2009.09.024","article-title":"Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy-treated mother","volume":"124","author":"Flicker","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0040","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/1521-4141(200208)32:8<2156::AID-IMMU2156>3.0.CO;2-A","article-title":"Conversion of grass pollen allergen-specific human IgE into a protective IgG(1) antibody","volume":"32","author":"Flicker","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2005.09.039","article-title":"Allergic disease and sensitization in Steiner school children","volume":"117","author":"Floistrup","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2567.2007.02618.x","article-title":"Maternal\u2013fetal interaction: preconception immunization in mice prevents neonatal sensitization induced by allergen exposure during pregnancy and breastfeeding","volume":"122","author":"Fusaro","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2012.10.008_bib0055","first-page":"21","article-title":"Effect of maternal immunotherapy on immediate skin test reactivity, specific rye I IgG and IgE antibody, and total IgE of the children","volume":"67","author":"Glovsky","year":"1991","journal-title":"Ann. Allergy"},{"key":"10.1016\/j.imbio.2012.10.008_bib0060","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/jaoac\/87.6.1441","article-title":"Sensitization and allergic response and intervention therapy in animal models","volume":"87","author":"Helm","year":"2004","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.imbio.2012.10.008_bib0065","first-page":"49","article-title":"IgE suppression by maternal IgG","volume":"48","author":"Jarrett","year":"1983","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2012.10.008_bib0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1365-2222.2000.00771.x","article-title":"Cord blood levels of immunoglobulin G subclass antibodies to food and inhalant allergens in relation to maternal atopy and the development of atopic disease during the first 8 years of life","volume":"30","author":"Jenmalm","year":"2000","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.imbio.2012.10.008_bib0075","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0091-6749(94)90176-7","article-title":"Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species","volume":"94","author":"Laffer","year":"1994","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0080","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nri1934","article-title":"Immunological mechanisms of allergen-specific immunotherapy","volume":"6","author":"Larche","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0085","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.4049\/jimmunol.178.6.3924","article-title":"Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy","volume":"178","author":"Linhart","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4049\/jimmunol.38.1.25","article-title":"Immunological studies of pollinosis. I. The presence of two antibodies related to the same pollen antigen in the serum of treated hay fever patients","volume":"38","author":"Loveless","year":"1940","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0095","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000093283","article-title":"Allergen-specific polyclonal antibodies reduce allergic disease in a mouse model of allergic asthma","volume":"140","author":"Moerch","year":"2006","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0091-6749(86)90123-5","article-title":"Combined active and passive immunotherapy in honeybee-sting allergy","volume":"78","author":"Muller","year":"1986","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0105","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0091-6749(98)70391-4","article-title":"IgE antibodies to recombinant pollen allergens (Phl p 1, Phl p 2, Phl p 5, and Bet v 2) account for a high percentage of grass pollen-specific IgE","volume":"101","author":"Niederberger","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0091-6749(98)70273-8","article-title":"Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations","volume":"102","author":"Niederberger","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0115","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.4049\/jimmunol.0803018","article-title":"High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography","volume":"182","author":"Padavattan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0120","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jaci.2008.09.017","article-title":"Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis","volume":"122","author":"Pauli","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0125","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1111\/j.1365-2222.2008.03096.x","article-title":"Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma","volume":"38","author":"Polte","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.imbio.2012.10.008_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2008.09.014","article-title":"Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma","volume":"122","author":"Polte","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0135","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.4049\/jimmunol.171.4.2080","article-title":"Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma","volume":"171","author":"Sehra","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0140","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1365-2222.2011.03804.x","article-title":"Mechanisms of immunotherapy to aeroallergens","volume":"41","author":"Shamji","year":"2011","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.imbio.2012.10.008_bib0145","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI25575","article-title":"IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking","volume":"116","author":"Strait","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2012.10.008_bib0150","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.4049\/jimmunol.171.7.3485","article-title":"Critical role of preconceptional immunization for protective and nonpathological specific immunity in murine neonates","volume":"171","author":"Uthoff","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2172-11-11","article-title":"Maternal immunization with ovalbumin prevents neonatal allergy development and up-regulates inhibitory receptor Fc gamma RIIB expression on B cells","volume":"11","author":"Victor","year":"2010","journal-title":"BMC Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0160","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4049\/jimmunol.157.2.956","article-title":"Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1","volume":"157","author":"Visco","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0165","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.151.9.4773","article-title":"cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl p V allergen","volume":"151","author":"Vrtala","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.008_bib0170","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2362.2008.01938.x","article-title":"Different allergenic activity of grass pollen allergens revealed by skin testing","volume":"38","author":"Westritschnig","year":"2008","journal-title":"Eur. J. Clin. Invest."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512005189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512005189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:33:46Z","timestamp":1759250026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298512005189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0171298512005189"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2012.10.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717973532.793470139","asserted-by":"object"}]},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Passive immunization with allergen-specific IgG antibodies for treatment and prevention of allergy","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2012.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}