{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:55:40Z","timestamp":1784908540836,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Madeleine Schickedanz KinderKrebs Stiftung"},{"name":"LOEWE Center for Cell and Gene Therapy Frankfurt"},{"DOI":"10.13039\/501100003495","name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst (HMWK)","doi-asserted-by":"crossref","award":["III L 4-518\/17.004"],"award-info":[{"award-number":["III L 4-518\/17.004"]}],"id":[{"id":"10.13039\/501100003495","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.imbio.2012.10.013","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T17:30:57Z","timestamp":1351877457000},"page":"939-944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Rhizopus oryzae hyphae are damaged by human natural killer (NK) cells, but suppress NK cell mediated immunity"],"prefix":"10.1016","volume":"218","author":[{"given":"Stanislaw","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Tramsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Perkhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Hanisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"R\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klingebiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Koehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lehrnbecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2012.10.013_bib0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cellimm.2008.08.007","article-title":"Relationship between CD107a expression and cytotoxic activity","volume":"254","author":"Aktas","year":"2009","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0010","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/intimm\/12.8.1173","article-title":"RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation","volume":"12","author":"Appay","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0015","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1182\/blood-2005-04-1660","article-title":"Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus","volume":"107","author":"Beck","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2012.10.013_bib0020","first-page":"187","article-title":"Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-gamma release","author":"Bouzani","year":"2011","journal-title":"J. Immunol."},{"issue":"Suppl. 5","key":"10.1016\/j.imbio.2012.10.013_bib0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1469-0691.2009.02978.x","article-title":"Incidence of zygomycosis in transplant recipients","volume":"15","author":"Cuenca-Estrella","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.imbio.2012.10.013_bib0030","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1099\/jmm.0.46121-0","article-title":"Invasive fungal infections are associated with severe depletion of circulating RANTES","volume":"54","author":"Ellis","year":"2005","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.169.1.99","article-title":"Antibacterial activity of human natural killer cells","volume":"169","author":"Garcia-Penarrubia","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2012.10.013_bib0040","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bbmt.2009.01.019","article-title":"Natural killer cells in allogeneic transplantation: effect on engraftment, graft-versus-tumor, and graft-versus-host responses","volume":"15","author":"Gill","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.imbio.2012.10.013_bib0045","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/CJI.0b013e3181bb46f7","article-title":"IL-2-driven regulation of NK cell receptors with regard to the distribution of CD16+ and CD16\u2212 subpopulations and in vivo influence after haploidentical NK cell infusion","volume":"33","author":"Huenecke","year":"2010","journal-title":"J. Immunother."},{"key":"10.1016\/j.imbio.2012.10.013_bib0050","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1348-0421.2000.tb02601.x","article-title":"NK cells eliminate Cryptococcus neoformans by potentiating the fungicidal activity of macrophages rather than by directly killing them upon stimulation with IL-12 and IL-18","volume":"44","author":"Kawakami","year":"2000","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0055","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/651263","article-title":"Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001\u20132006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database","volume":"50","author":"Kontoyiannis","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.imbio.2012.10.013_bib0060","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1046\/j.1365-2141.2001.02995.x","article-title":"Activation of natural killer cells with interleukin 2 (IL-2) and IL-12 increases perforin binding and subsequent lysis of tumour cells","volume":"114","author":"Lehmann","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0065","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.4049\/jimmunol.173.5.3357","article-title":"NK cells use perforin rather than granulysin for anticryptococcal activity","volume":"173","author":"Ma","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0070","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1128\/IAI.01232-08","article-title":"Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity","volume":"77","author":"Marr","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.10.013_bib0075","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1182\/blood-2004-07-2974","article-title":"Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer","volume":"105","author":"Miller","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2012.10.013_bib0080","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/IAI.74.2.1403-1406.2006","article-title":"Killed Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells","volume":"74","author":"Murciano","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.10.013_bib0085","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4049\/jimmunol.128.4.1577","article-title":"In vitro reactivity of natural killer (NK) cells against Cryptococcus neoformans","volume":"128","author":"Murphy","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0090","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1128\/iai.65.11.4564-4571.1997","article-title":"Direct interactions of human natural killer cells with Cryptococcus neoformans inhibit granulocyte-macrophage colony-stimulating factor and tumor necrosis factor alpha production","volume":"65","author":"Murphy","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2012.10.013_bib0095","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.4049\/jimmunol.0803462","article-title":"Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis","volume":"182","author":"Park","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0100","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.beha.2006.06.004","article-title":"Natural-killer-cell-based treatment in haematopoietic stem-cell transplantation","volume":"19","author":"Passweg","year":"2006","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bcmd.2007.06.029","article-title":"NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation","volume":"40","author":"Ruggeri","year":"2008","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.imbio.2012.10.013_bib0115","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/infdis\/jiq062","article-title":"Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia","volume":"203","author":"Schmidt","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2012.10.013_bib0120","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.4049\/jimmunol.162.11.6658","article-title":"Perforin is a major contributor to NK cell control of tumor metastasis","volume":"162","author":"Smyth","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1473-3099(10)70316-9","article-title":"Mucormycosis: its contemporary face and management strategies","volume":"11","author":"Sun","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.imbio.2012.10.013_bib0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11908-010-0130-3","article-title":"Challenges and prospects of adoptive immunotherapy in prevention and treatment of opportunistic mycoses in hematologic transplant recipients","volume":"12","author":"Tramsen","year":"2010","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.imbio.2012.10.013_bib0135","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/tox.10050","article-title":"The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells","volume":"17","author":"Wichmann","year":"2002","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.imbio.2012.10.013_bib0140","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.4049\/jimmunol.178.10.6456","article-title":"Perforin-dependent cryptococcal microbicidal activity in NK cells requires PI3K-dependent ERK1\/2 signaling","volume":"178","author":"Wiseman","year":"2007","journal-title":"J. Immunol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512005232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298512005232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:34:57Z","timestamp":1759250097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298512005232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0171298512005232"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2012.10.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717980750.793471780","asserted-by":"object"}]},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhizopus oryzae hyphae are damaged by human natural killer (NK) cells, but suppress NK cell mediated immunity","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2012.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}