{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:34:52Z","timestamp":1759332892250,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.imbio.2013.11.001","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T22:03:18Z","timestamp":1384984998000},"page":"292-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative mucosal immunogenicity of HIV gp41 membrane-proximal external region (MPER) containing single and multiple repeats of ELDKWA sequence with defensin peptides"],"prefix":"10.1016","volume":"219","author":[{"given":"Teena","family":"Mohan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.N.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2013.11.001_bib0005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/1476-8518-1-5","article-title":"Generating neutralizing antibodies, Th1 response and MHC non-restricted immunogenicity of HIV-I env and gag peptides in liposomes and ISCOMs with in-built adjuvanticity","volume":"1","author":"Agrawal","year":"2003","journal-title":"J. Immune Based Ther. Vaccines"},{"key":"10.1016\/j.imbio.2013.11.001_bib0010","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.6189183","article-title":"Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Barre-Sinoussi","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.imbio.2013.11.001_bib0015","doi-asserted-by":"crossref","first-page":"6992","DOI":"10.4049\/jimmunol.169.12.6992","article-title":"High affinity mimotope of the polysaccharide capsule of Cryptococcus neoformans identified from an evolutionary phage peptide library","volume":"169","author":"Beenhouwer","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4419-1132-2_14","article-title":"Innovative approaches to develop prophylactic and therapeutic vaccines against HIV\/AIDS","volume":"655","author":"Cafaro","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0025","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0264-410X(00)00267-X","article-title":"Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein","volume":"19","author":"Coeffier","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1126\/science.300.5616.28a","article-title":"Clinical research. A setback and an advance on the AIDS vaccine front","volume":"300","author":"Cohen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.imbio.2013.11.001_bib0035","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1016\/j.vaccine.2007.06.062","article-title":"Influence of the route of immunization and the nature of the bacterial vector on immunogenicity of mucosal vaccines based on lactic acid bacteria","volume":"25","author":"Cortes-Perez","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0040","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1128\/JVI.76.2.517-524.2002","article-title":"Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization","volume":"76","author":"Curtis","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0045","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1099\/0022-1317-77-9-2001","article-title":"Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus","volume":"77","author":"Eckhart","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0050","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.4049\/jimmunol.177.7.4276","article-title":"Cutting edge: uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis","volume":"177","author":"Fukuyama","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0055","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1128\/jvi.66.6.3306-3315.1992","article-title":"Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins","volume":"66","author":"Gabuzda","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0060","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.6601823","article-title":"Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Gallo","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.imbio.2013.11.001_bib0065","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4049\/jimmunol.159.1.279","article-title":"Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope","volume":"159","author":"Garrity","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0070","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1086\/514209","article-title":"Analysis of intercurrent human immunodeficiency virus type 1 infections in phase I and II trials of candidate AIDS vaccines. AIDS Vaccine Evaluation Group, and the Correlates of HIV Immune Protection Group","volume":"177","author":"Graham","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2013.11.001_bib0075","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/360358a0","article-title":"Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160","volume":"360","author":"Hallenberger","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2013.11.001_bib0080","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1128\/JVI.01272-09","article-title":"Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L","volume":"84","author":"Hessell","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.virol.2009.05.015","article-title":"Characterization of a trimeric MPER containing HIV-1 gp41 antigen","volume":"390","author":"Hinz","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.imbio.2013.11.001_bib0090","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.vaccine.2004.09.037","article-title":"Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response","volume":"23","author":"Ho","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0095","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.sbi.2006.06.007","article-title":"Peptides in lipid bilayers: the power of simple models","volume":"16","author":"Killian","year":"2006","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0100","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri1439","article-title":"NALT- versus Peyer's-patch-mediated mucosal immunity","volume":"4","author":"Kiyono","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0105","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1074\/jbc.M411088200","article-title":"Trimeric membrane-anchored gp41 inhibits HIV membrane fusion","volume":"280","author":"Lenz","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2013.11.001_bib0110","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1016\/S0264-410X(99)00125-5","article-title":"Epitope insertion into variable loops of HIV-1 gp120 as a potential means to improve immunogenicity of viral envelope protein","volume":"17","author":"Liang","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/07391102.1997.10508958","article-title":"A trimeric structural subdomain of the HIV-1 transmembrane glycoprotein","volume":"15","author":"Lu","year":"1997","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.imbio.2013.11.001_bib0120","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1016\/j.vaccine.2005.06.031","article-title":"Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLGA microparticles in combination with UlexEuropaeus-I lectin as M cell target","volume":"23","author":"Manocha","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0125","article-title":"Nasal delivery of PLG microparticle encapsulated defensin peptides adjuvanted gp41 antigen confers strong and long-lasting immunoprotective response against HIV-1","author":"Mohan","year":"2013","journal-title":"Immunol. Res."},{"issue":"13","key":"10.1016\/j.imbio.2013.11.001_bib0130","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.vaccine.2013.01.041","article-title":"Modulation of HIV peptide antigen specific cellular immune response by synthetic \u03b1- and \u03b2-defensin peptides","volume":"31","author":"Mohan","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0135","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1128\/MMBR.00020-07","article-title":"The membrane proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design","volume":"72","author":"Montero","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.imbio.2013.11.001_bib0140","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.20021348","article-title":"Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control","volume":"198","author":"Mullins","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2013.11.001_bib0145","doi-asserted-by":"crossref","first-page":"ii17","DOI":"10.1136\/ard.62.suppl_2.ii17","article-title":"Roles of antimicrobial peptides such as defensins in innate and adaptive immunity","volume":"62","author":"Oppenheim","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imbio.2013.11.001_bib0150","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.virol.2007.11.005","article-title":"Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles","volume":"373","author":"Phogat","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.imbio.2013.11.001_bib0155","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1086\/508748","article-title":"Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand","volume":"194","author":"Pitisuttithum","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.imbio.2013.11.001_bib0160","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.intimp.2009.01.012","article-title":"Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses","volume":"9","author":"Pun","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0165","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1042\/bj3470633","article-title":"Large-scale synthesis and functional elements for the antimicrobial activity of defensins","volume":"347","author":"Raj","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.imbio.2013.11.001_bib0170","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1128\/JVI.73.3.2469-2480.1999","article-title":"A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity","volume":"73","author":"Salzwedel","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0175","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/aid.2004.20.1157","article-title":"RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates","volume":"20","author":"Sherry","year":"2004","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.imbio.2013.11.001_bib0180","doi-asserted-by":"crossref","first-page":"11659","DOI":"10.1128\/JVI.76.22.11659-11676.2002","article-title":"Both mucosal and systemic routes of immunization with the live, attenuated NYVAC\/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8+ T-cell responses in mucosal tissues of macaques","volume":"76","author":"Stevceva","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chemphyslip.2006.02.023","article-title":"Anchoring mechanisms of membrane-associated M13 major coat protein","volume":"141","author":"Stopar","year":"2006","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.imbio.2013.11.001_bib0190","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/intimm\/12.5.691","article-title":"Defensins act as potent adjuvant that promotes cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigen","volume":"12","author":"Tani","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0195","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1006\/bbrc.2001.4676","article-title":"The neutrophil granule protein cathepsin G activates murine T lymphocytes and upregulates antigen-specific Ig production in mice","volume":"282","author":"Tani","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.imbio.2013.11.001_bib0200","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ejmech.2011.01.046","article-title":"Viral surface glycoproteins, gp120 and gp41, as potential drug targets against HIV-1: brief overview one quarter of a century past the approval of zidovudine, the first anti-retroviral drug","volume":"46","author":"Teixeira","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.imbio.2013.11.001_bib0205","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.virol.2006.09.019","article-title":"Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV","volume":"359","author":"Thakar","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.imbio.2013.11.001_bib0210","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.vaccine.2006.01.031","article-title":"Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery","volume":"24","author":"Tripathi","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1517\/17425247.3.2.247","article-title":"Intranasal delivery of vaccines against HIV","volume":"3","author":"Vajdy","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.imbio.2013.11.001_bib0220","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1128\/JVI.00305-08","article-title":"Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion","volume":"82","author":"Vishwanathan","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0225","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1126\/science.280.5371.1884","article-title":"The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens","volume":"280","author":"Wyatt","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.imbio.2013.11.001_bib0230","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1471-4906(02)02246-9","article-title":"Mammalian defensins in immunity: more than just microbicidal","volume":"23","author":"Yang","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.immunol.22.012703.104603","article-title":"Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense","volume":"22","author":"Yang","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2013.11.001_bib0240","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1371\/journal.pone.0014813","article-title":"Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA\/gp41 chimeric protein-based DNA and VLP vaccines","volume":"6","author":"Ye","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.imbio.2013.11.001_bib0245","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1016\/j.vaccine.2007.09.017","article-title":"Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and protective efficacy against SIV (mac251)","volume":"25","author":"Zhou","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2013.11.001_bib0250","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/JVI.79.2.1252-1261.2005","article-title":"Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1","volume":"79","author":"Zwick","year":"2005","journal-title":"J. Virol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298513001976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298513001976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:36:41Z","timestamp":1759250201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298513001976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0171298513001976"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2013.11.001","relation":{},"ISSN":["0171-2985"],"issn-type":[{"type":"print","value":"0171-2985"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative mucosal immunogenicity of HIV gp41 membrane-proximal external region (MPER) containing single and multiple repeats of ELDKWA sequence with defensin peptides","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2013.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}