{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:34:14Z","timestamp":1791052454597,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.imbio.2014.03.013","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T11:31:47Z","timestamp":1396092707000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Histone deacetylase inhibitor valproic acid affects plasmacytoid dendritic cells phenotype and function"],"prefix":"10.1016","volume":"219","author":[{"given":"Jessy","family":"Arbez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Lamarth\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Gaugler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Saas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2014.03.013_bib0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.immuni.2006.08.010","article-title":"Type I interferon in systemic lupus erythematosus and other autoimmune diseases","volume":"25","author":"Banchereau","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2014.03.013_bib0010","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/11360","article-title":"Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon","volume":"5","author":"Cella","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2014.03.013_bib0015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/79747","article-title":"Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization","volume":"1","author":"Cella","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2009.08.019","article-title":"Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target","volume":"16","author":"Chauhan","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2014.03.013_bib0025","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2119\/molmed.2011.00007","article-title":"HDAC inhibition and graft versus host disease","volume":"17","author":"Choi","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.imbio.2014.03.013_bib0030","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1141","article-title":"Plasmacytoid dendritic cells in immunity","volume":"5","author":"Colonna","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0035","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S1470-2045(13)70398-X","article-title":"Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study","volume":"14","author":"Dimopoulos","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0040","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1158\/0008-5472.CAN-12-2409","article-title":"ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells","volume":"72","author":"Faget","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.imbio.2014.03.013_bib0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)61689-6","article-title":"Plasmacytoid dendritic cells (natural interferon-alpha\/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions","volume":"159","author":"Farkas","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0050","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.exphem.2012.06.008","article-title":"Impact of HDAC inhibitors on dendritic cell functions","volume":"40","author":"Frikeche","year":"2012","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0055","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.imbio.2011.11.010","article-title":"Impact of valproic acid on dendritic cells function","volume":"217","author":"Frikeche","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2014.03.013_bib0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nm.3179","article-title":"Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells","volume":"19","author":"Gagliani","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2014.03.013_bib0065","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2358","article-title":"Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases","volume":"8","author":"Gilliet","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0070","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2119\/molmed.2011.00069","article-title":"Inhibition of histone deacetylases in inflammatory bowel diseases","volume":"17","author":"Glauben","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.imbio.2014.03.013_bib0075","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses","volume":"434","author":"Honda","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2014.03.013_bib0080","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide","volume":"449","author":"Lande","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2014.03.013_bib0085","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1200\/JCO.2009.22.1291","article-title":"Histone deacetylase inhibitors in cancer therapy","volume":"27","author":"Lane","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0090","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1073\/pnas.052702999","article-title":"The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines","volume":"99","author":"Leoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2014.03.013_bib0095","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature11428","article-title":"A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses","volume":"490","author":"Litvak","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2014.03.013_bib0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc1779","article-title":"Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer","volume":"6","author":"Minucci","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.imbio.2014.03.013_bib0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production","volume":"202","author":"Nestle","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2014.03.013_bib0110","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S1470-2045(13)70425-X","article-title":"Histone deacetylase inhibitors in multiple myeloma","volume":"14","author":"Pratt","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0115","first-page":"2562","article-title":"Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice","volume":"118","author":"Reddy","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2014.03.013_bib0120","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.283.5405.1183","article-title":"Reciprocal control of T helper cell and dendritic cell differentiation","volume":"283","author":"Rissoan","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.imbio.2014.03.013_bib0125","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nm.2305","article-title":"Cancer epigenetics reaches mainstream oncology","volume":"17","author":"Rodriguez-Paredes","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2014.03.013_bib0130","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1182\/blood-2010-05-284711","article-title":"Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection","volume":"117","author":"Roger","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2014.03.013_bib0135","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/BOR.0b013e32835c7e32","article-title":"The interferon signature in autoimmune diseases","volume":"25","author":"Ronnblom","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.imbio.2014.03.013_bib0140","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.imbio.2010.05.023","article-title":"Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells","volume":"215","author":"Salvi","year":"2010","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2014.03.013_bib0145","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1126\/science.284.5421.1835","article-title":"The nature of the principal type 1 interferon-producing cells in human blood","volume":"284","author":"Siegal","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.imbio.2014.03.013_bib0150","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1158\/0008-5472.CAN-11-3468","article-title":"Impaired IFN-alpha production by plasmacytoid dendritic cells favors regulatory T-cell expansion that may contribute to breast cancer progression","volume":"72","author":"Sisirak","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.imbio.2014.03.013_bib0155","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/leu.2010.244","article-title":"HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells","volume":"25","author":"Song","year":"2011","journal-title":"Leukemia"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298514000618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298514000618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:37:25Z","timestamp":1759250245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298514000618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0171298514000618"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2014.03.013","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone deacetylase inhibitor valproic acid affects plasmacytoid dendritic cells phenotype and function","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2014.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}