{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:04:18Z","timestamp":1791288258942,"version":"4.3.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"UNIUBE"},{"name":"UFTM"},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.imbio.2015.04.004","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T13:23:24Z","timestamp":1430141004000},"page":"1006-1011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus"],"prefix":"10.1016","volume":"220","author":[{"given":"Janusa Maria","family":"Muniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-3636","authenticated-orcid":false,"given":"Cl\u00e1udia Renata","family":"Bibiano Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Beghini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Sivieri","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polyanna","family":"Miranda Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Margareth Biagioni","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San\u00edvia Aparecida de Lima","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchele Dias","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Henrique","family":"Napimoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Virmondes","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Bertulucci Rocha","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2015.04.004_bib0065","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1681\/ASN.2004110915","article-title":"Galectin-9 inhibits glomerular hypertrophy in db\/db diabetic mice via cell-cycle-dependent mechanisms","volume":"16","author":"Baba","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0155","first-page":"261","article-title":"Galectin-3, and endogenous lectin, as a tool for monitoring cell differentiation in head and neck carcinomas with implications for lectin\u2013glycan functionality","volume":"123","author":"Betka","year":"2003","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0055","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1755-148X.2012.01026.x","article-title":"The sweet and bitter sides of galectins in melanoma progression","volume":"25","author":"Braeuer","year":"2012","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.imbio.2015.04.004_bib0020","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0964-1955(94)90033-7","article-title":"The prognostic effect of tobacco and alcohol consumption in intra-oral squamous cell carcinoma","volume":"30B","author":"Bundgaard","year":"1994","journal-title":"Eur. J. Cancer B: Oral. Oncol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0135","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1038\/sj.onc.1207997","article-title":"Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3","volume":"23","author":"Califice","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.imbio.2015.04.004_bib0180","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.177.8.4991","article-title":"Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression","volume":"177","author":"Chen","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0125","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1073\/pnas.92.4.1213","article-title":"Identification of galectin-3 as a factor in pre-mRNA splicing","volume":"92","author":"Dagher","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2015.04.004_bib0050","first-page":"983","article-title":"Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development","volume":"21","author":"Ding","year":"2009","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.imbio.2015.04.004_bib0070","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: an open-ended story","volume":"1760","author":"Dumic","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.imbio.2015.04.004_bib0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.imbio.2015.04.004_bib0060","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00018-007-7044-8","article-title":"Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival","volume":"64","author":"Elola","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.imbio.2015.04.004_bib0040","first-page":"187","article-title":"General considerations and clinical management of oral leukoplakia","volume":"3","author":"Gabriel","year":"2004","journal-title":"Rev. Brasiselira Patol. Oral"},{"key":"10.1016\/j.imbio.2015.04.004_bib0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00011-005-0059-4","article-title":"Inflammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis","volume":"55","author":"Gil","year":"2006","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.imbio.2015.04.004_bib0165","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/labinvest.2011.188","article-title":"SOX2 contributes to melanoma cell invasion","volume":"92","author":"Girouard","year":"2012","journal-title":"Lab. Investig."},{"key":"10.1016\/j.imbio.2015.04.004_bib0140","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1023\/B:GLYC.0000014085.00706.d4","article-title":"90K (Mac-2 BP) and galectins in tumor progression and metastasis","volume":"19","author":"Grassadonia","year":"2004","journal-title":"Glyconconj. J."},{"key":"10.1016\/j.imbio.2015.04.004_bib0175","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-0714.2003.00128.x","article-title":"Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma","volume":"32","author":"Iamaroon","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.imbio.2015.04.004_bib0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1586\/14737140.7.3.317","article-title":"Diagnosis and therapy of oral squamous cell carcinoma","volume":"7","author":"Konkimalla","year":"2007","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.imbio.2015.04.004_bib0015","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJM200104263441710","article-title":"Molecular markers of the risk of oral cancer","volume":"344","author":"Lippman","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2015.04.004_bib0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrc1527","article-title":"Galectins as modulators of tumour progression","volume":"5","author":"Liu","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.imbio.2015.04.004_bib0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1749-6632.2009.05131.x","article-title":"Galectins: regulators of acute and chronic inflammation","volume":"1183","author":"Liu","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.imbio.2015.04.004_bib0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3892\/mmr.2012.1125","article-title":"Galectin-9 promotes TGF-\u03b21-dependent induction of regulatory T cells via the TGF-\u03b2\/Smad signaling pathway","volume":"7","author":"Lv","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.imbio.2015.04.004_bib0025","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.oraloncology.2012.01.017","article-title":"Biomarkers of oral premalignant epithelial lesions for clinical application","volume":"48","author":"Mishra","year":"2012","journal-title":"Oral Oncol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.oraloncology.2011.12.006","article-title":"Ras oncogenes in oral cancer: the past 20 years","volume":"48","author":"Murugan","year":"2012","journal-title":"Oral Oncol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0160","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1200\/JCO.2000.18.5.1135","article-title":"Matrix metalloproteinases: biologic activity and clinical implications","volume":"18","author":"Nelson","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0035","series-title":"Patologia Oral & Maxilofacial","first-page":"388","article-title":"Patologia epitelial","author":"Neville","year":"2009"},{"key":"10.1016\/j.imbio.2015.04.004_bib0120","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1023\/B:GLYC.0000014082.99675.2f","article-title":"Extracellular functions of galectin-3","volume":"19","author":"Ochieng","year":"2004","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.imbio.2015.04.004_bib0080","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ijc.22534","article-title":"A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines","volume":"120","author":"Okudaira","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.imbio.2015.04.004_bib0170","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.oraloncology.2006.05.004","article-title":"Decrease in mast cells in oral squamous cell carcinoma: possible failure in the migration of these cells","volume":"43","author":"Oliveira-Neto","year":"2007","journal-title":"Oral Oncol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.imbio.2015.04.004_bib0110","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/sj.bjc.6602493","article-title":"Galectin-1 as a potential cancer target","volume":"92","author":"Rabinovich","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.imbio.2015.04.004_bib0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00418-005-0074-0","article-title":"Nuclear presence of adhesion-\/growth-regulatory galectins in normal\/malignant cells of squamous epithelial origin","volume":"125","author":"Smetana","year":"2006","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0045","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1834-7819.2002.tb00540.x","article-title":"Oral lichen planus: causes, diagnosis and management","volume":"47","author":"Sugerman","year":"2002","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.imbio.2015.04.004_bib0145","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1128\/MCB.24.10.4395-4406.2004","article-title":"Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs","volume":"24","author":"Takenaka","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.imbio.2015.04.004_bib0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/1097-0215(20000720)89:4<361::AID-IJC8>3.0.CO;2-U","article-title":"Alternation of the cytoplasmic\/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression","volume":"89","author":"Van Den Brule","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.imbio.2015.04.004_bib0095","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1002\/med.20249","article-title":"Therapeutic potential of Galectin-9 in human disease","volume":"33","author":"Wiersma","year":"2013","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.imbio.2015.04.004_bib0100","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat. Immunol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298515000595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298515000595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:38:24Z","timestamp":1759250304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298515000595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0171298515000595"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2015.04.004","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2015.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}