{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:09:09Z","timestamp":1776348549421,"version":"3.51.2"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Economic competitiveness support programme, ARC-OVI"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.imbio.2015.09.002","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T21:43:17Z","timestamp":1441316597000},"page":"236-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immune gene expression profiling of PBMC isolated from horses vaccinated with attenuated African horsesickness virus serotype 4"],"prefix":"10.1016","volume":"221","author":[{"given":"A.","family":"Pretorius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.E.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Kleef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Janurary (1)","key":"10.1016\/j.imbio.2015.09.002_bib0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-2427(02)00274-X","article-title":"The effect of strenuous exercise on mRNA concentrations of interleukin-12, interferon-gamma and interleukin-4 in equine pulmonary and peripheral blood mononuclear cells","volume":"91","author":"Ainsworth","year":"2003","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"June (29)","key":"10.1016\/j.imbio.2015.09.002_bib0010","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.vaccine.2014.04.036","article-title":"Vaccination of horses with a recombinant modified vaccinia Ankara virus (MVA) expressing African horsesickness (AHS) virus major capsid protein VP2 provides complete clinical protection against challenge","volume":"32","author":"Alberca","year":"2014","journal-title":"Vaccine"},{"issue":"June (6)","key":"10.1016\/j.imbio.2015.09.002_bib0015","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1158\/1940-6207.CAPR-11-0212","article-title":"Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq","volume":"4","author":"Beane","year":"2011","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"April (3)","key":"10.1016\/j.imbio.2015.09.002_bib0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02970145","article-title":"Viral mimicry of the complement system","volume":"28","author":"Bernet","year":"2003","journal-title":"J. Biosci."},{"issue":"October (2)","key":"10.1016\/j.imbio.2015.09.002_bib0025","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1006\/viro.1993.1537","article-title":"Neutralizing epitopes of African horsesickness virus serotype 4 are located on VP2","volume":"196","author":"Burrage","year":"1993","journal-title":"Virology"},{"issue":"Feburary (180)","key":"10.1016\/j.imbio.2015.09.002_bib0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.virusres.2013.12.002","article-title":"Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunisation","volume":"13","author":"Calvo-Pinilla","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.imbio.2015.09.002_bib0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.antiviral.2015.01.009","article-title":"Antiserum from mice vaccinated with modified vaccinia Ankara virus expressing African horse sickness virus (AHSV) VP2 provides protection when it is administered 48h before, or 48h after challenge","volume":"116","author":"Calvo-Pinilla","year":"2015","journal-title":"Antiviral Res."},{"key":"10.1016\/j.imbio.2015.09.002_bib0040","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1084\/jem.20111171","article-title":"Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans","volume":"12","author":"Caskey","year":"2011","journal-title":"J. Exp. Med."},{"issue":"Janurary (1)","key":"10.1016\/j.imbio.2015.09.002_bib0045","doi-asserted-by":"crossref","first-page":"e16503","DOI":"10.1371\/journal.pone.0016503","article-title":"A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -\/- mouse model","volume":"6","author":"Castillo-Olivares","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2015.09.002_bib0050","first-page":"12","article-title":"Sensing and control of bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases","volume":"99","author":"Chauveau","year":"2012","journal-title":"J. Virol."},{"issue":"May (1\u20132)","key":"10.1016\/j.imbio.2015.09.002_bib0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.vetimm.2006.01.013","article-title":"Cytokine responses to EHV-1 infection in immune and non-immune ponies","volume":"111","author":"Coombs","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"Janurary (5)","key":"10.1016\/j.imbio.2015.09.002_bib0060","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.virol.2012.09.012","article-title":"Anti-viral CD8 T cells and the cytokines that they love","volume":"435","author":"Cox","year":"2013","journal-title":"Virology"},{"issue":"December (3\u20134)","key":"10.1016\/j.imbio.2015.09.002_bib0065","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.vetmic.2014.10.006","article-title":"Study of the virulence of serotypes 4 and 9 of African horse sickness virus in IFNAR(-\/-), Balb\/C and 129Sv\/Ev mice","volume":"174","author":"de la Grandi\u00e8re","year":"2014","journal-title":"Vet. Microbiol."},{"issue":"July (7)","key":"10.1016\/j.imbio.2015.09.002_bib0070","doi-asserted-by":"crossref","first-page":"e70197","DOI":"10.1371\/journal.pone.0070197","article-title":"Ns1 is a key protein in the vaccine composition to protect Ifnar(-\/-) mice against infection with multiple serotypes of African horse sickness virus","volume":"8","author":"de la Poza","year":"2013","journal-title":"PLoS One"},{"issue":"July (14)","key":"10.1016\/j.imbio.2015.09.002_bib0075","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1128\/JVI.78.14.7528-7535.2004","article-title":"CC chemokine receptor 7 expression by effector\/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection","volume":"78","author":"Debes","year":"2004","journal-title":"J. Virol."},{"issue":"September (18)","key":"10.1016\/j.imbio.2015.09.002_bib0080","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1128\/JVI.01235-14","article-title":"Dual modulation of type I interferon response by bluetongue virus","volume":"9","author":"Doceul","year":"2014","journal-title":"J. Virol."},{"issue":"September (1\u20132)","key":"10.1016\/j.imbio.2015.09.002_bib0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vetimm.2012.06.009","article-title":"An African horse sickness virus serotype 4 recombinant canarypox virus vaccine elicits specific cell-mediated immune responses in horses","volume":"149","author":"El Garch","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"October (1\u20132)","key":"10.1016\/j.imbio.2015.09.002_bib0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.vetimm.2008.09.028","article-title":"Differential induction of MyD88- and TRIF-dependent pathways in equine monocytes by Toll-like receptor agonists","volume":"11","author":"Figueiredo","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"July (33)","key":"10.1016\/j.imbio.2015.09.002_bib0095","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1016\/j.vaccine.2009.05.044","article-title":"Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus","volume":"27","author":"Guthrie","year":"2009","journal-title":"Vaccine"},{"issue":"Janurary (1)","key":"10.1016\/j.imbio.2015.09.002_bib0100","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4049\/jimmunol.1200571","article-title":"Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection","volume":"190","author":"Hamada","year":"2013","journal-title":"J. Immunol."},{"issue":"Sptember 39","key":"10.1016\/j.imbio.2015.09.002_bib0105","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1016\/j.vaccine.2014.07.031","article-title":"Immunogenicity of recombinant VP2 proteins of all nine serotypes of African horsesickness virus","volume":"32","author":"Kanai","year":"2014","journal-title":"Vaccine"},{"issue":"December (47)","key":"10.1016\/j.imbio.2015.09.002_bib0110","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.3748\/wjg.14.7149","article-title":"Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection","volume":"14","author":"Larrubia","year":"2008","journal-title":"World J. Gastroenterol."},{"issue":"March 1-3","key":"10.1016\/j.imbio.2015.09.002_bib0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetimm.2008.10.303","article-title":"Genomic and non-genomic effects of dexamethasone on equine peripheral blood neutrophils","volume":"128","author":"Lecoq","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"October 7","key":"10.1016\/j.imbio.2015.09.002_bib0120","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.4049\/jimmunol.1301454","article-title":"IL-21-producing Th cells in immunity and autoimmunity","volume":"191","author":"Liu","year":"2013","journal-title":"J. Immunol."},{"issue":"December 4","key":"10.1016\/j.imbio.2015.09.002_bib0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"March 71-7","key":"10.1016\/j.imbio.2015.09.002_bib0130","article-title":"The immune response of ruminant livestock to bluetongue virus: from type I interferon to antibody","volume":"182","author":"Maclachlan","year":"2014","journal-title":"Virus Res."},{"issue":"July\u2013August 4","key":"10.1016\/j.imbio.2015.09.002_bib0135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1051\/vetres:2004021","article-title":"African horse sickness","volume":"5","author":"Mellor","year":"2004","journal-title":"Vet Res."},{"issue":"September 1","key":"10.1016\/j.imbio.2015.09.002_bib0140","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.4049\/jimmunol.169.5.2712","article-title":"Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers","volume":"169","author":"Menzies-Gow","year":"2002","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.imbio.2015.09.002_bib0145","doi-asserted-by":"crossref","first-page":"e41645","DOI":"10.1371\/journal.pone.0041645","article-title":"Deep sequencing-based transcriptome analysis of chicken spleen in response to avian pathogenic E. coli (APEC) infection","volume":"7","author":"Nie","year":"2012","journal-title":"PLoS One"},{"issue":"March 1","key":"10.1016\/j.imbio.2015.09.002_bib0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.vetimm.2012.01.016","article-title":"Virus-specific CD8\u207a T- cells detected in PBMC from horses vaccinated against African horse sickness virus","volume":"146","author":"Pretorius","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"Janurary (Pt 1)","key":"10.1016\/j.imbio.2015.09.002_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.83391-0","article-title":"Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures","volume":"89","author":"Randall","year":"2008","journal-title":"J. Gen. Virol."},{"issue":"November 10","key":"10.1016\/j.imbio.2015.09.002_bib0160","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.4049\/jimmunol.1100917","article-title":"IL-17 boosts proinflammatory outcome of antiviral response in human cells","volume":"187","author":"Ryzhakov","year":"2011","journal-title":"J. Immunol."},{"issue":"November (10)","key":"10.1016\/j.imbio.2015.09.002_bib0165","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1086\/379196","article-title":"Toll-like receptor and cytokine expression patterns of CD56+ T cells are similar to natural killer cells in response to infection with Venezuelan equine encephalitis virus replicons","volume":"188","author":"Saikh","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"Janurary (7\u20138)","key":"10.1016\/j.imbio.2015.09.002_bib0170","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0264-410X(01)00445-5","article-title":"The protective efficacy of a recombinant VP2-based African horsesickness subunit vaccine candidate is determined by adjuvant","volume":"20","author":"Scanlen","year":"2002","journal-title":"Vaccine"},{"issue":"Feburary (2)","key":"10.1016\/j.imbio.2015.09.002_bib0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"issue":"April (9)","key":"10.1016\/j.imbio.2015.09.002_bib0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2014.03.003","article-title":"Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV","volume":"15","author":"Stacey","year":"2014","journal-title":"Host Microbe. Cell"},{"issue":"June (1)","key":"10.1016\/j.imbio.2015.09.002_bib0185","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/viro.1996.0304","article-title":"Immunization with VP2 is sufficient for protection against lethal challenge with African horsesickness virus Type 4","volume":"220","author":"Stone-Marschat","year":"1996","journal-title":"Virology"},{"issue":"March (3)","key":"10.1016\/j.imbio.2015.09.002_bib0190","doi-asserted-by":"crossref","first-page":"e0121015","DOI":"10.1371\/journal.pone.0121015","article-title":"De novo transcriptomic analysis of peripheral blood lymphocytes from the chinese goose: gene discovery and immune system pathway description","volume":"10","author":"Tariq","year":"2015","journal-title":"PLoS One"},{"issue":"Sptember (10)","key":"10.1016\/j.imbio.2015.09.002_bib0195","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1084\/jem.20101664","article-title":"Type I interferon: friend or foe?","volume":"207","author":"Trinchieri","year":"2010","journal-title":"J. Exp. Med."},{"issue":"Janurary (1)","key":"10.1016\/j.imbio.2015.09.002_bib0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/01.ATV.0000095360.62479.1F","article-title":"Fractalkine in vascular biology: from basic research to clinical disease","volume":"24","author":"Umehara","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"September 1","key":"10.1016\/j.imbio.2015.09.002_bib0205","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.173.5.3013","article-title":"Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity","volume":"173","author":"Unsoeld","year":"2004","journal-title":"J. Immunol."},{"issue":"December 23","key":"10.1016\/j.imbio.2015.09.002_bib0210","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2915.2009.00829.x","article-title":"The oral susceptibility of South African field populations of Culicoides to African horse sickness virus","volume":"23","author":"Venter","year":"2009","journal-title":"Med. Vet. Entomol."},{"key":"10.1016\/j.imbio.2015.09.002_bib0215","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virusres.2013.10.027","article-title":"Induction and control of the type I interferon pathway by Bluetongue virus","volume":"182","author":"Vitour","year":"2014","journal-title":"Virus Res."},{"issue":"November (6)","key":"10.1016\/j.imbio.2015.09.002_bib0220","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/cmi.2011.38","article-title":"A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection","volume":"8","author":"Wang","year":"2011","journal-title":"Cell Mol. Immunol."},{"issue":"August (4)","key":"10.1016\/j.imbio.2015.09.002_bib0225","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cytogfr.2010.04.002","article-title":"IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties","volume":"21","author":"Witte","year":"2010","journal-title":"Cytokine Growth Factor Rev."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129851530053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129851530053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:40:09Z","timestamp":1759250409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S017129851530053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S017129851530053X"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2015.09.002","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune gene expression profiling of PBMC isolated from horses vaccinated with attenuated African horsesickness virus serotype 4","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2015.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}