{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:36:38Z","timestamp":1791351398486,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["18590906"],"award-info":[{"award-number":["18590906"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.imbio.2015.12.001","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T01:32:16Z","timestamp":1450229536000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer\u2019s patch by cholera toxin B induce the glomerular deposition of IgA"],"prefix":"10.1016","volume":"221","author":[{"given":"Takahiro","family":"Yamanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Tamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Horikoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Terashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Iwabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonoko","family":"Habu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2015.12.001_bib0005","first-page":"694","article-title":"Intercapillary deposits of IgA-IgG","volume":"74","author":"Berger","year":"1968","journal-title":"J. Urol. Nephrol. (Paris)"},{"key":"10.1016\/j.imbio.2015.12.001_bib0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ki.1990.35","article-title":"Transforming growth factor- beta regulates production of proteoglycans by mesangial cells","volume":"37","author":"Border","year":"1990","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2015.12.001_bib0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5414\/CNP65385","article-title":"Roles of TGF-beta1 and poptosis in the progerssion of glomerulosclerosis in human IgA nephropathy","volume":"65","author":"Chihara","year":"2006","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0020","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.4049\/jimmunol.159.5.2327","article-title":"The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines","volume":"159","author":"Chintalacharuvu","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0025","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1046\/j.1365-2249.2001.01678.x","article-title":"T cell cytokines determine the severity of experimental IgA nephropathy by regulating IgA glycosylation","volume":"126","author":"Chintalacharuvu","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0030","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1365-2249.2008.03703.x","article-title":"T cell cytokine polarity as a determinant of immunoglobulin A (IgA) glycosylation and the severity of experimental IgA nephropathy","volume":"153","author":"Chintalacharuvu","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0035","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.4049\/jimmunol.133.6.2892","article-title":"Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen","volume":"133","author":"Elson","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0040","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1164\/ajrccm.156.2.9610043","article-title":"Bronchiolitis obliterans and IgA nephropathy. A new cause of pulmonary-renal syndrome","volume":"156","author":"Hernandez","year":"1997","journal-title":"Am. J. Respir. Crit. Care. Med."},{"issue":"4","key":"10.1016\/j.imbio.2015.12.001_bib0045","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.ajpath.2012.06.038","article-title":"Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes","volume":"181","author":"Hashimoto","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0050","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1046\/j.1523-1755.1999.00369.x","article-title":"Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis","volume":"55","author":"Holdsworth","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.imbio.2015.12.001_bib0055","first-page":"104","article-title":"Impact of annual urine health check-up system to obtain clinical remission in patients with IgA nephropathy","volume":"157","author":"Ieiri","year":"2007","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0060","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0016-5085(98)70091-5","article-title":"Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy","volume":"115","author":"Iijima","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.imbio.2015.12.001_bib0065","first-page":"209","article-title":"Glomerulonephritis with mesangial deposits of IgA unassociated with systemic disease","volume":"114","author":"Katz","year":"1976","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.imbio.2015.12.001_bib0070","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1097\/01.ASN.0000065550.13931.00","article-title":"Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis","volume":"14","author":"Kitching","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0075","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1093\/ndt\/17.12.2108","article-title":"Interleukin-12 alters the physicochemical characteristics of serum and glomerular IgA and modifies glycosylation in a ddY mouse strain having high IgA levels","volume":"17","author":"Kobayashi","year":"2002","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.imbio.2015.12.001_bib0080","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ni.2362","article-title":"The transcription factor Sox4 is a downstream taraget of signaling by the cytokine TGF-\u03b2and supresses TH2 differentiation","volume":"13","author":"Kuwahara","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0085","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.4049\/jimmunol.155.10.4621","article-title":"Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4","volume":"155","author":"Marinaro","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0090","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1172\/JCI45563","article-title":"Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy","volume":"121","author":"McCarthy","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imbio.2015.12.001_bib0095","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1681\/ASN.2006040388","article-title":"Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy","volume":"17","author":"Oortwijn","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0100","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0022-3476(73)80064-2","article-title":"Recurrent macroscopic hematuria, focal nephritis, and mesangial deposition of immunoglobulin and complement","volume":"82","author":"Roy","year":"1973","journal-title":"J. Pediatr."},{"key":"10.1016\/j.imbio.2015.12.001_bib0105","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/0264-410X(95)00231-O","article-title":"Humoral and cellular immune responses in the murine respiratory tract following oral immunization with cholera toxin or E. coli heat-labile enterotoxin","volume":"14","author":"Ruedl","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.imbio.2015.12.001_bib0110","first-page":"213","article-title":"Familial IgA nephropathy","volume":"12","author":"Scolari","year":"1999","journal-title":"J. Nephrol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0115","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0272-6386(99)70417-8","article-title":"Familial clustering of IgA nephropathy: further evidence in an Italian population","volume":"33","author":"Scolari","year":"1999","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.imbio.2015.12.001_bib0120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1525-1470.2008.00797.x","article-title":"Familial clusturing of Henoch\u2013Schonlein purpura or IgA nephropathy: genetic background or environmental triggers?","volume":"25","author":"Shin","year":"2008","journal-title":"Pediatr. Dermatol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0125","doi-asserted-by":"crossref","first-page":"e0141116","DOI":"10.1371\/journal.pone.0141116","article-title":"Orally-induced intestinal CD4+ CD25+ FoxP3+ treg controlled undesired responses towards oral antigens and effectively dampened food allergic reactions","volume":"10","author":"Smaldini","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2015.12.001_bib0130","first-page":"863","article-title":"Familial IgA nephropathy","volume":"41","author":"Song","year":"2003","journal-title":"Zhonghua Er. Ke. Za. Zhi."},{"key":"10.1016\/j.imbio.2015.12.001_bib0135","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1084\/jem.170.4.1415","article-title":"Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production","volume":"170","author":"Sonoda","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2015.12.001_bib0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0065-2776(08)60866-4","article-title":"Antibody class switching","volume":"61","author":"Stavnezer","year":"1996","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0145","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1074\/jbc.M113.512277","article-title":"Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes","volume":"289","author":"Suzuki","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2015.12.001_bib0150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.imbio.2005.07.001","article-title":"Oral antigen induces antigen-specific activation of intraepithelial CD4+ lymphocytes but suppresses their activation in spleen","volume":"210","author":"Tamauchi","year":"2005","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2015.12.001_bib0155","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/intimm\/dxh026","article-title":"Evidence of GATA-3-dependent Th2 commitment during the in vivo immune response","volume":"16","author":"Tamauchi","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.imbio.2015.12.001_bib0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.immuni.2011.02.002","article-title":"Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction","volume":"34","author":"Tezuka","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2015.12.001_bib0165","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0272-6386(99)70228-3","article-title":"Risk factors for IgA nephropathy: a case-control study in Japan","volume":"33","author":"Wakai","year":"1999","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.imbio.2015.12.001_bib0170","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1093\/ndt\/gfq325","article-title":"Down-regulation of core 1 beta1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1","volume":"25","author":"Yamada","year":"2010","journal-title":"Nephrol. Dial. Transplant."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298515301017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298515301017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:40:07Z","timestamp":1759250407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298515301017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0171298515301017"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2015.12.001","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer\u2019s patch by cholera toxin B induce the glomerular deposition of IgA","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2015.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier GmbH","name":"copyright","label":"Copyright"}]}}