{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:57:13Z","timestamp":1791212233991,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["2015\/17\/B\/NZ6\/01969"],"award-info":[{"award-number":["2015\/17\/B\/NZ6\/01969"]}]},{"name":"National Science Center"},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.imbio.2016.07.007","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T13:03:53Z","timestamp":1469279033000},"page":"1382-1394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein"],"prefix":"10.1016","volume":"221","author":[{"given":"Anna","family":"Gmiterek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"K\u0142opot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"W\u00f3jtowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya C.","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-8144","authenticated-orcid":false,"given":"Teresa","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2016.07.007_bib0005","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1128\/IAI.72.8.4689-4698.2004","article-title":"In vitro models of tissue penetration and destruction by Porphyromonas gingivalis","volume":"72","author":"Andrian","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0010","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1128\/IAI.69.12.7387-7395.2001","article-title":"Bacterial fimbriae and their peptides activate human gingival epithelial cells through toll-like receptor 2","volume":"69","author":"Asai","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2008-04-151712","article-title":"Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology","volume":"113","author":"Baenziger","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2016.07.007_bib0020","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1006\/bbrc.1999.1075","article-title":"Rapid and efficient inactivation of IL-6 gingipains: lysine- and arginine-specific proteinases from Porphyromonas gingivalis","volume":"261","author":"Banbula","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0025","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4161\/auto.2828","article-title":"A highway for Porphyromonas gingivalis in endothelial cells","volume":"2","author":"Belanger","year":"2006","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.imbio.2016.07.007_bib0030","doi-asserted-by":"crossref","first-page":"e0118319","DOI":"10.1371\/journal.pone.0118319","article-title":"Pyocyanin, a contributory factor in haem acquisition and virulence enhancement of Porphyromonas gingivalis in the lung","volume":"10","author":"Benedyk","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2016.07.007_bib0035","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.4049\/jimmunol.1403176","article-title":"TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-\u03b2 production via a TAK1-IKK\u03b2-IRF5 signaling pathway","volume":"195","author":"Bergstrom","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0040","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.micinf.2004.11.021","article-title":"Modulation of cytokine production by Porphyromonas gingivalis in a macrophage and epithelial cell co-culture model","volume":"7","author":"Bodet","year":"2005","journal-title":"Microbes Infect."},{"key":"10.1016\/j.imbio.2016.07.007_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2012.02579.x","article-title":"Porphyromonas gingivalis: an invasive and evasive opportunistic pathogen","volume":"333","author":"Bostanci","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.imbio.2016.07.007_bib0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1741-7015-10-122","article-title":"Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation","volume":"10","author":"Bullon","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.imbio.2016.07.007_bib0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/omi.12018","article-title":"Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia","volume":"28","author":"Byrne","year":"2013","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0060","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1471-2180-13-206","article-title":"Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells","volume":"13","author":"Carvalho-Filho","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0065","doi-asserted-by":"crossref","first-page":"7465852","DOI":"10.1155\/2016\/7465852","article-title":"Role of Porphyromonas gingivalis HmuY in immunopathogenesis of chronic periodontitis","volume":"2016","author":"Carvalho-Filho","year":"2016","journal-title":"Mediators Inflamm."},{"issue":"5","key":"10.1016\/j.imbio.2016.07.007_bib0070","doi-asserted-by":"crossref","first-page":"e00927","DOI":"10.1128\/genomeA.00927-15","article-title":"Genome sequence of Porphyromonas gingivalis strain A7436","volume":"3","author":"Chastain-Gross","year":"2015","journal-title":"Genome Announc."},{"key":"10.1016\/j.imbio.2016.07.007_bib0075","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1902\/jop.2003.74.7.1007","article-title":"Relationship of destructive periodontal disease to the acute-phase response","volume":"74","author":"Craig","year":"2003","journal-title":"J. Periodontol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1462-5822.2002.00164.x","article-title":"Bacterial interactions with the autophagic pathway","volume":"4","author":"Dorn","year":"2002","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0085","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4049\/jimmunol.1403173","article-title":"TLR8 senses bacterial RNA in human monocytes and plays a nonredundant role for recognition of Streptococcus pyogenes","volume":"195","author":"Eigenbrod","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000181145","article-title":"High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism","volume":"1","author":"Fitzpatrick","year":"2009","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0095","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s002849900297","article-title":"Cytokine degradation by biofilms of Porphyromonas gingivalis","volume":"36","author":"Fletcher","year":"1998","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1128\/IAI.01140-12","article-title":"Hemoglobin receptor protein from Porphyromonas gingivalis induces IL-8 production in human gingival epithelial cells through stimulation of the MAPK and NF-\u03baB signal transduction pathways","volume":"82","author":"Fujita","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0105","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1128\/IAI.00009-09","article-title":"Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments","volume":"77","author":"Furuta","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0110","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1128\/IAI.00841-09","article-title":"Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment","volume":"77","author":"Furuta","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0115","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.molimm.2009.05.022","article-title":"Requirement of TLR4 and CD14 in dendritic cell activation by hemagglutinin B from Porphyromonas gingivalis","volume":"46","author":"Gaddis","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0120","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.4049\/jimmunol.1003192","article-title":"TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Poprphyromonas gingivalis hemagglutinin B","volume":"186","author":"Gaddis","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0125","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.2741\/2822","article-title":"Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis","volume":"13","author":"Gibson","year":"2008","journal-title":"Front. Biosci."},{"issue":"7","key":"10.1016\/j.imbio.2016.07.007_bib0130","doi-asserted-by":"crossref","first-page":"e67719","DOI":"10.1371\/journal.pone.0067719","article-title":"The unique hmuY gene sequence as a specific marker of Porphyromonas gingivalis infection","volume":"8","author":"Gmiterek","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2016.07.007_bib0135","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1902\/jop.2013.130509","article-title":"Does periodontal infection have an effect on severe asthma in adults?","volume":"85","author":"Gomes-Filho","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0140","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3109\/08820139.2015.1070269","article-title":"Differential gene expression profiles reflecting macrophage polarization in aging and periodontitis gingival tissues","volume":"44","author":"Gonzalez","year":"2015","journal-title":"Immunol. Invest."},{"issue":"54","key":"10.1016\/j.imbio.2016.07.007_bib0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0757.2010.00377.x","article-title":"Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon\u2019s knife to a meat chopper-like brutal degradation of proteins","volume":"2000","author":"Guo","year":"2010","journal-title":"Periodontology"},{"key":"10.1016\/j.imbio.2016.07.007_bib0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1574-695X.2011.00877.x","article-title":"Colocalization of Porphyromonas gingivalis with CD4+ T cells in periodontal disease","volume":"64","author":"Guyodo","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0155","first-page":"403","article-title":"Dependence of bacterial protein adhesins on Toll-like receptors for proinflammatory cytokine induction","volume":"9","author":"Hajishengallis","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1349-0079(11)80006-X","article-title":"Immune evasion strategies of Porphyromonas gingivalis","volume":"53","author":"Hajishengallis","year":"2011","journal-title":"J. Oral Biosci."},{"key":"10.1016\/j.imbio.2016.07.007_bib0165","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrd3203","article-title":"Targeting Toll-like receptors: emerging therapeutics?","volume":"9","author":"Hennessy","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.imbio.2016.07.007_bib0170","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1128\/IAI.69.3.1477-1482.2001","article-title":"Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages","volume":"69","author":"Hirschfeld","year":"2001","journal-title":"Infect. Immun."},{"issue":"20","key":"10.1016\/j.imbio.2016.07.007_bib0175","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0757.1999.tb00162.x","article-title":"Virulence factors of Porphyromonas gingivalis","volume":"2000","author":"Holt","year":"1999","journal-title":"Periodontology"},{"key":"10.1016\/j.imbio.2016.07.007_bib0180","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1128\/IAI.69.11.7146-7151.2001","article-title":"Assessment of internalization and viability of Porphyromonas gingivalis in KB epithelial cells by confocal microscopy","volume":"69","author":"Houalet-Jeanne","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0185","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1128\/IAI.69.3.1364-1372.2001","article-title":"Interleukin-8 and intercellular adhesion molecule I regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms","volume":"69","author":"Huang","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0190","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.micpath.2004.10.003","article-title":"Differential regulation of cytokine genes in gingival epithelial cells challenge by Fusobacterium nucleatum and Porphyromonas gingivalis","volume":"37","author":"Huang","year":"2004","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.imbio.2016.07.007_bib0195","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/omi.12089","article-title":"Porphyromonas gingivalis RagB is a pro-inflammatory signal transducer and activator of transcription 4 agonist","volume":"30","author":"Hutcherson","year":"2014","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0266-4356(03)00190-6","article-title":"Brain abscess in which Porphyromonas gingivalis was detected in cerebrospinal fluid","volume":"42","author":"Iida","year":"2004","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.imbio.2016.07.007_bib0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1601-0825.1998.tb00255.x","article-title":"The role of IL-6 in the pathogenesis of periodontal disease","volume":"4","author":"Irwin","year":"1998","journal-title":"Oral Dis."},{"key":"10.1016\/j.imbio.2016.07.007_bib0210","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/cmi.12435","article-title":"Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation","volume":"17","author":"Jung","year":"2015","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0215","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.micinf.2005.09.004","article-title":"Detection of bacterial DNA in atheromatous plaques by quantitative PCR","volume":"8","author":"Kozarov","year":"2006","journal-title":"Microbes Infect."},{"issue":"52","key":"10.1016\/j.imbio.2016.07.007_bib0220","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0757.2009.00311.x","article-title":"Subgingival biofilm formation","volume":"2000","author":"Kuboniwa","year":"2010","journal-title":"Periodontology"},{"key":"10.1016\/j.imbio.2016.07.007_bib0225","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.1400853","article-title":"Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice","volume":"193","author":"Lam","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0230","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1128\/iai.63.10.3878-3885.1995","article-title":"Porphyromonas gingivalis invasion of gingival epithelial cells","volume":"63","author":"Lamont","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0235","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1902\/jop.2007.060368","article-title":"Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor","volume":"78","author":"Leon","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0240","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1399-302X.1996.tb00190.x","article-title":"Effect of oral bacteria on peripheral blood leukocyte interleukin-6 and soluble interleukin-6 receptor production","volume":"11","author":"Lindemann","year":"1996","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0245","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.4049\/jimmunol.146.5.1541","article-title":"Lipopolysaccharide, tumor necrosis factor-alpha, and IL-1 beta prevent programmed cell death (apoptosis) in human peripheral blood monocytes","volume":"146","author":"Mangan","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0250","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000077756","article-title":"Dental plaque as a microbial biofilm","volume":"38","author":"Marsh","year":"2004","journal-title":"Caries Res."},{"key":"10.1016\/j.imbio.2016.07.007_bib0255","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1128\/iai.61.2.588-595.1993","article-title":"Purification and characterization of fibroblast-activating factor isolated from Porphyromonas gingivalis W50","volume":"61","author":"Mihara","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0260","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1128\/iai.61.8.3562-3564.1993","article-title":"Role of Porphyromonas gingivalis-derived fibroblast-activating factor in bone resorption","volume":"61","author":"Mihara","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0265","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.imbio.2014.09.010","article-title":"\u2018Ride on the ferrous wheel\u2019 \u2013 the cycle of iron in macrophages in health and disease","volume":"220","author":"Nairz","year":"2015","journal-title":"Immunobiology"},{"issue":"10","key":"10.1016\/j.imbio.2016.07.007_bib0270","doi-asserted-by":"crossref","first-page":"e26163","DOI":"10.1371\/journal.pone.0026163","article-title":"Outer membrane vesicles of Porphyromonas gingivalis elicit a mucosal immune response","volume":"6","author":"Nakao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2016.07.007_bib0275","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1074\/jbc.M114.591610","article-title":"Attenuation of the PI3 kinase\/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp","volume":"290","author":"Nakayama","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2016.07.007_bib0280","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","article-title":"Cytokine expression in periodontal health and disease","volume":"9","author":"Okada","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.imbio.2016.07.007_bib0285","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00203-007-0309-7","article-title":"Porphyromonas gingivalis HmuY and HmuR: further characterization of a novel mechanism of heme utilization","volume":"183","author":"Olczak","year":"2008","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0290","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2180-10-134","article-title":"Species specificity, surface exposure, protein expression, immunogenicity, and participation in biofilm formation of Porphyromonas gingivalis HmuY","volume":"10","author":"Olczak","year":"2010","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0295","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.bbrc.2015.10.070","article-title":"HmuY is an important virulence factor for Porphyromonas gingivalis growth in the heme-limited host environment and infection of macrophages","volume":"467","author":"Olczak","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0300","doi-asserted-by":"crossref","first-page":"28788","DOI":"10.3402\/jom.v7.28788","article-title":"Invasion of Porphyromonas gingivalis strains into vascular cells and tissue","volume":"7","author":"Olsen","year":"2015","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0305","article-title":"Porphyromonas gingivalis induces authophagy in THP-1-derived macrophages","author":"Park","year":"2016","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0310","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000181144","article-title":"Corruption of innate immunity by bacterial proteases","volume":"1","author":"Potempa","year":"2009","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0315","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.atherosclerosis.2011.09.003","article-title":"The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature","volume":"221","author":"Qin","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.imbio.2016.07.007_bib0320","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10753-004-6641-z","article-title":"Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis","volume":"28","author":"Rosenstein","year":"2004","journal-title":"Inflammation"},{"key":"10.1016\/j.imbio.2016.07.007_bib0325","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/pr070031u","article-title":"Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components","volume":"6","author":"Saba","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.imbio.2016.07.007_bib0330","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1128\/IAI.70.10.5740-5750.2002","article-title":"Nuclear targeting of Porphyromonas gingivalis W50 protease in epithelial cells","volume":"70","author":"Scragg","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0335","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14419\/ijpt.v2i2.3027","article-title":"Toll like receptors: an overview","volume":"2","author":"Shah","year":"2014","journal-title":"Int. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0340","article-title":"Haem acquisition mechanisms of Porphyromonas gingivalis \u2212strategies used in polymicrobial community in a haem-limited host environment","author":"Smalley","year":"2016","journal-title":"Mol. Oral Microbiol."},{"issue":"2","key":"10.1016\/j.imbio.2016.07.007_bib0345","doi-asserted-by":"crossref","first-page":"e17182","DOI":"10.1371\/journal.pone.0017182","article-title":"HmuY haemophore and gingipain proteases constitute a unique synthrophic system of haem acquisition by Porphyromonas gingivalis","volume":"6","author":"Smalley","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2016.07.007_bib0350","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1399-302X.2008.00467.x","article-title":"The host cytokine response to Porphyromonas gingivalis is modified by gingipains","volume":"29","author":"Stathopoulou","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0355","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.0902-0055.2003.00119.x","article-title":"Differential cytokine induction by two types of Porphyromonas gingivalis","volume":"19","author":"Sugano","year":"2004","journal-title":"Oral Microbiol. Immunol."},{"issue":"54","key":"10.1016\/j.imbio.2016.07.007_bib0360","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0757.2009.00344.x","article-title":"Cytokine regulation of immune responses to Porphyromonas gingivalis","volume":"2000","author":"Taylor","year":"2010","journal-title":"Periodontolgy"},{"key":"10.1016\/j.imbio.2016.07.007_bib0365","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0765.2011.01401.x","article-title":"Induction of interleukin (IL)-1\u03b2, IL-10, IL-8 and immunoglobulin G by Porphyromonas gingivalis in humans","volume":"47","author":"Trindade","year":"2012","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.imbio.2016.07.007_bib0370","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.archoralbio.2011.09.003","article-title":"Porphyromonas gingivalis antigens participate differently in the proliferation and cell death of human PBMC","volume":"57","author":"Trindade","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0375","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1902\/jop.2012.120230","article-title":"Porphyromonas gingivalis HmuY-induced production of interleukin-6 and IL-6 polymorphism in chronic periodontitis","volume":"84","author":"Trindade","year":"2013","journal-title":"J. Periodontol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0380","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.20042372","article-title":"Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR) 7-and TLR9-mediated interferon-\u03b1 induction","volume":"201","author":"Uematsu","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2016.07.007_bib0385","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1021\/pr401227e","article-title":"Porphyromonas gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors","volume":"13","author":"Veith","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.imbio.2016.07.007_bib0390","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/j.1462-5822.2008.01185.x","article-title":"Lipid raft-dependent uptake, signaling and intracellular fate of Porphyromonas gingivalis in mouse macrophages","volume":"10","author":"Wang","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0395","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.179.4.2349","article-title":"Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages","volume":"179","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0400","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1254\/jjp.80.75","article-title":"Effect of cysteine protease of Porphyromonas gingivalis on adhesion molecules in gingival epithelial cells","volume":"80","author":"Wang","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0405","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JCM.00793-06","article-title":"Osteomyelitis of the ulna caused by Porphyromonas gingivalis","volume":"44","author":"Welkerling","year":"2006","journal-title":"J. Clin. Microbiol."},{"issue":"5","key":"10.1016\/j.imbio.2016.07.007_bib0410","doi-asserted-by":"crossref","first-page":"e1000419","DOI":"10.1371\/journal.ppat.1000419","article-title":"Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis","volume":"5","author":"Wojtowicz","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imbio.2016.07.007_bib0415","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1128\/IAI.01013-06","article-title":"Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells","volume":"75","author":"Yamatake","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0420","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1462-5822.2009.01390.x","article-title":"ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis","volume":"12","author":"Yilmaz","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0425","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/IAI.74.1.703-710.2006","article-title":"Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells","volume":"74","author":"Yilmaz","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2016.07.007_bib0430","first-page":"1","article-title":"Enhanced activity of the macrophage M1\/M2 phenotypes and phenotypic switch to M1 in periodontal infection","volume":"13","author":"Yu","year":"2016","journal-title":"J. Periodontol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0435","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4238\/2014.March.31.1","article-title":"Study of Hgp44 from Porphyromonas gingivalis on inducing HUVECs to secrete IL-6 and IL-8","volume":"13","author":"Zhang","year":"2014","journal-title":"Gen. Mol. Res."},{"key":"10.1016\/j.imbio.2016.07.007_bib0440","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.4049\/jimmunol.179.11.7777","article-title":"Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components","volume":"179","author":"Zhou","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2016.07.007_bib0445","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/IAI.73.2.935-943.2005","article-title":"Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein","volume":"73","author":"Zhou","year":"2005","journal-title":"Infect. Immun."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298516303266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298516303266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:41:02Z","timestamp":1759250462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298516303266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":89,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0171298516303266"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2016.07.007","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2016.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}